Abstract：
BACKGROUND:Monoamine oxidase (MAO) is a critical enzyme in deamination of biogenic amines and may be involved in the pathophysiology of major psychosis, including mood disorder and schizophrenia. Recently, evidence for genetic association between the MAO-A gene and bipolar mood disorder was obtained in Caucasians. METHODS:We investigated the polymorphisms of the MAO-A gene, which may be related to enzyme activity (T/941/G, A/1609/G), with amino-acid change (A/1609/G), in Japanese patients with bipolar disorder patients (n = 132), unipolar major depression (n = 43), or schizophrenia (n = 95), and controls (n = 169). RESULTS:No difference in the allele frequencies or genotype distribution of the T/941/G variation was observed between any disease group and the control group. As for the A/1609/G variation, no G allele was found in the Japanese subjects. CONCLUSIONS:No evidence for the genetic association between the MAO-A gene and major psychosis was obtained in the Japanese subjects.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Sasaki T,Hattori M,Sakai T,Kato T,Kunugi H,Hirose T,Nanko Sdoi
10.1016/s0006-3223(97)00522-2subject
Has Abstractpub_date
1998-11-01 00:00:00pages
922-4issue
9eissn
0006-3223issn
1873-2402pii
S0006-3223(97)00522-2journal_volume
44pub_type
杂志文章abstract：BACKGROUND:Impaired neuromotor development is often one of the earliest observations in children with autism spectrum disorder (ASD). We investigated whether a genetic predisposition to developmental disorders was associated with nonoptimal neuromotor development during infancy and examined the genetic correlation betw...
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
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