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Parenteral clomipramine challenge in depressed adolescents: mood and neuroendocrine response.

Abstract：

BACKGROUND:Major depressive disorder (MDD) in the adolescent demonstrates a unique clinical profile, and pathogenic serotonergic dysregulation is hypothesized. Parenteral clomipramine (CMI) is known to distinguish adult MDD from control, but neurochallenge data are lacking in adolescent MDD. METHODS:Thirteen drug-free outpatient adolescents who met DSM-III-R criteria for MDD were compared to adolescent controls by acute neuroendocrine and mood response to 12.5 mg of parenteral CMI. RESULTS:Repeated measures analysis revealed significant changes from baseline for sadness (p < .01) between groups, with normal controls increasing sadness rating after CMI. Prolactin (PRL) maximum change score from baseline was decreased in MDD relative to controls (p < .05). Gender effects on PRL were evident in controls but not in MDD. CONCLUSIONS:The findings of PRL blunting in adolescent MDD mirrors previous work in adults. A unique finding is the induction of sadness in normal adolescent controls after CMI infusion.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Sallee FR,Vrindavanam NS,Deas-Nesmith D,Odom AM,Carson SW,Sethuraman G

doi

10.1016/s0006-3223(97)00447-2

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

562-7

issue

7

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(97)00447-2

journal_volume

44

pub_type

临床试验,杂志文章

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