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Striatal dopamine synthesis in first-degree relatives of patients with schizophrenia.

Abstract：

BACKGROUND:First degree relatives (FDR) of patients with schizophrenia have higher risk of developing schizophrenia than the general population. Previous positron emission tomography (PET) studies have shown that striatal presynaptic dopamine synthesis capacity is increased in schizophrenia. We investigated whether this same phenomenon is shared by individuals with increased genetic risk for schizophrenia. METHODS:We used 6-[18F]-fluorodopa (FDOPA) PET imaging to measure striatal dopamine synthesis capacity. We studied 17 nonpsychotic subjects with an FDR with schizophrenia. This group was compared to 17 healthy subjects with no FDRs with schizophrenia. RESULTS:A conventional region of interest (ROI)-analysis indicated that FDOPA uptake (K(i)) in the caudate-putamen was statistically significantly higher in the FDR group than in the control group. A voxel-level analysis confirmed these results. CONCLUSIONS:These results suggest that the changes of striatal presynaptic dopamine synthesis seen previously in neuroleptic-naive schizophrenic patients is also present in FDRs of patients with schizophrenia. These findings have implications for the early detection of psychosis as well as for pharmacological interventions in individuals at risk for psychosis.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Huttunen J,Heinimaa M,Svirskis T,Nyman M,Kajander J,Forsback S,Solin O,Ilonen T,Korkeila J,Ristkari T,McGlashan T,Salokangas RK,Hietala J

doi

10.1016/j.biopsych.2007.04.017

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

114-7

issue

1

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(07)00368-X

journal_volume

63

pub_type

杂志文章

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