Abstract:
BACKGROUND:The presence of a comorbid tic disorder may predict a poorer outcome in the acute treatment of pediatric obsessive-compulsive disorder (OCD). METHODS:Using data from the National Institute of Mental Health (NIMH)-funded Pediatric OCD Treatment Study (POTS) that compared cognitive-behavior therapy (CBT), medical management with sertraline (SER), and the combination of CBT and SER (COMB), to pill placebo (PBO) in children and adolescents with OCD, we asked whether the presence of a comorbid tic disorder influenced symptom reduction on the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) after 12 weeks of treatment. RESULTS:Fifteen percent (17 of 112) of patients exhibited a comorbid tic disorder. In patients without tics, results replicated previously published intent-to-treat outcomes: COMB > CBT > SER > PBO. In patients with a comorbid tic disorder, SER did not differ from PBO, while COMB remained superior to CBT and CBT remained superior to PBO. CONCLUSIONS:In contrast to CBT outcomes, which are not differentially impacted, tic disorders appear to adversely impact the outcome of medication management of pediatric OCD. Children and adolescents with obsessive-compulsive disorder and a comorbid tic disorder should begin treatment with cognitive-behavior therapy alone or the combination of cognitive-behavior therapy plus a serotonin reuptake inhibitor.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
March JS,Franklin ME,Leonard H,Garcia A,Moore P,Freeman J,Foa Edoi
10.1016/j.biopsych.2006.09.035subject
Has Abstractpub_date
2007-02-01 00:00:00pages
344-7issue
3eissn
0006-3223issn
1873-2402pii
S0006-3223(06)01274-1journal_volume
61pub_type
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journal_title:Biological psychiatry
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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更新日期:2016-04-15 00:00:00
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pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,随机对照试验
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更新日期:2008-07-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0006-3223(97)00546-5
更新日期:1999-02-01 00:00:00