Abstract：
:Cocaine can cause a variety of neuropsychiatric and neurobehavioral complications; however, it is uncertain whether cocaine causes persistent cerebral structural and neurochemical abnormalities in asymptomatic users. We studied 52 African-American men (26 human immunodeficiency virus-negative asymptomatic heavy cocaine users and 26 normal subjects). Ventricle-to-brain ratio (VBR) and white matter lesions (WML) were quantified on magnetic resonance imaging. N-acetyl-containing compounds (NA), total creatine, choline-containing compounds, myo-inositol, and glutamate + glutamine were measured with in vivo proton magnetic resonance spectroscopy, VBR and WML were not significantly different in the cocaine users compared to the normal controls. Elevated creatine (+7%; p = .05) and myo-inositol (+18%; p = .01) in the white matter were associated with cocaine use. NA, primarily a measure of N-acetyl aspartate and neuronal content, was normal. Normal NA suggest no neuronal loss or damage in the brain regions examined in these cocaine users. Therefore, we conclude that neurochemical abnormalities observed might result from alterations in nonneuronal brain tissue.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Chang L,Mehringer CM,Ernst T,Melchor R,Myers H,Forney D,Satz Pdoi
10.1016/s0006-3223(97)00135-2subject
Has Abstractpub_date
1997-12-15 00:00:00pages
1105-14issue
12eissn
0006-3223issn
1873-2402pii
S0006322397001352journal_volume
42pub_type
临床试验,杂志文章abstract：:The behavioral effects of a 2 mg/kg iv bolus infusion of naloxone were compared with a placebo infusion using a double-blind design in a small group of inpatient depressives (n = 6) and normals (n = 8). Naloxone produced consistent and significant worsening in the rated signs and subjective symptoms of depression in t...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：
更新日期：1984-06-01 00:00:00
abstract：BACKGROUND:Antenatal maternal cortisol levels associate with alterations in the amygdala, a structure associated with emotion regulation, in the offspring. However, because offspring brain and behavior are commonly assessed years after birth, the timing of such maternal influences is unclear. This study aimed to examin...
journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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pub_type： 杂志文章
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(95)00430-0
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.05.021
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journal_title：Biological psychiatry
pub_type： 杂志文章
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journal_title：Biological psychiatry
pub_type： 杂志文章
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.03.019
更新日期：2008-09-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(94)90023-x
更新日期：1994-06-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/S0006-3223(96)00179-5
更新日期：1997-04-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.11.013
更新日期：2009-05-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1996-03-15 00:00:00
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pub_type： 杂志文章
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更新日期：2020-01-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.07.024
更新日期：2007-08-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2015.02.020
更新日期：2015-08-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1993-03-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(98)00134-6
更新日期：1998-09-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(98)00229-7
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2005.04.041
更新日期：2005-11-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.01.004
更新日期：2008-01-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1981-11-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.01.006
更新日期：2004-04-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(03)00543-2
更新日期：2003-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-02-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(02)01459-2
更新日期：2002-12-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/S0006-3223(95)00672-9
更新日期：1997-01-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(86)90241-6
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/0006-3223(90)90050-c
更新日期：1990-05-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(01)01115-5
更新日期：2001-06-15 00:00:00
abstract：:There has been an explosion of research on fear extinction in humans in the past 2 decades. This has not only generated major insights, but also brought a new goal into focus: how to maintain extinction memory over time (i.e., extinction retention). We argue that there are still important conceptual and procedural cha...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2019.02.011
更新日期：2019-06-15 00:00:00
