Antiretroviral antibodies: implications for schizophrenia, schizophrenia spectrum disorders, and bipolar disorder.

Abstract:

BACKGROUND:Some retroviral antigens share structural homology within a group of related retroviruses. It is possible that antibodies directed against one virus may cross-react with antigens from a different virus in the group. METHODS:Using this principle, the human immunodeficiency virus 1 (HIV-1) Western blot assay was used as an available source of human retroviral antigens to screen serum samples from an archived collection to ascertain whether there was an association between serum antiretroviral antibodies and mental illnesses. RESULTS:A statistically significant proportion (28/54, 52%) of patients suffering from psychiatric disorders had serum antibodies that recognized at least one antigen present on the blot, culminating in indeterminate HIV-1 tests. The majority of the reactive samples were directed against the HIV-1 group antigens p24 and p17. These findings contrast with those of nonpsychiatric patients, who had 4/16 (25%) indeterminate blots. CONCLUSIONS:The results suggest exposure to retroviral antigens related to those of HIV-1 in subpopulations of schizophrenic, schizophrenic spectrum disorder, and bipolar disorder patients.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Hart DJ,Heath RG,Sautter FJ Jr,Schwartz BD,Garry RF,Choi B,Beilke MA,Hart LK

doi

10.1016/s0006-3223(98)00229-7

subject

Has Abstract

pub_date

1999-03-15 00:00:00

pages

704-14

issue

6

eissn

0006-3223

issn

1873-2402

pii

S0006322398002297

journal_volume

45

pub_type

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