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Short-term effects of the calcium channel blocker nimodipine (Bay-e-9736) in the management of primary degenerative dementia.

Abstract：

:The etiology of Alzheimer's dementia (AD) is unknown, but several neurotransmitters, e.g., acetylcholine, have been implicated. Recently, the group of calcium channel antagonists have been reviewed for their potential neuropsychiatric applications. These agents are capable of enhancing cholinergic tone, neurofilament/microtubular stabilization, and regional perfusion rates. The following is a report of a randomized, double-blind, placebo-controlled, multicenter study of 227 AD patients treated with nimodipine, a 1.4 dihydropyridine derivative and calcium channel antagonist. The subgroup receiving active drug (30 mg t.i.d.) experienced a prophylactic benefit across eight measures over 12 treatment weeks when contrasted with the disease progression seen among placebo recipients. Calcium channel blockers as neurotransmitter modulators and/or via calcium's theoretical role in neurofibrillary tangles, proteolysis, or neurofilament formation may represent a therapeutic opportunity for the AD patient.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Tollefson GD

doi

10.1016/0006-3223(90)90050-c

subject

Has Abstract

pub_date

1990-05-15 00:00:00

pages

1133-42

issue

10

eissn

0006-3223

issn

1873-2402

pii

0006-3223(90)90050-C

journal_volume

27

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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