Emotional development and psychiatry.

abstract：BACKGROUND:In a Swedish study, delinquent boys had high serum levels of triiodothyronine (T3). Furthermore, former delinquents, followed up after about 30 years, had T3 levels significantly related to repeated criminality. The aim of the present study was to shed further light on the relationship between the thyroid ho...

journal_title：Biological psychiatry

authors： Stålenheim EG,von Knorring L,Wide L

更新日期：1998-05-15 00:00:00

abstract：BACKGROUND:Although cocaine is known to be a highly addictive drug, there appears to be a select subset of individuals who are able to use the substance recreationally without developing dependence. These individuals do not report experiencing feelings of craving for cocaine, an important distinction from dependent use...

journal_title：Biological psychiatry

authors： Smith DG,Simon Jones P,Bullmore ET,Robbins TW,Ersche KD

更新日期：2014-01-15 00:00:00

abstract：:A group of 759 patients with final DSM-I and -II diagnoses of schizophrenia was identified among a cohort of 1494 adults who were hospitalized between 1965 and 1972. Admission EEG recordings were done in each patient during waking, activation procedures, drowsiness, and sleep. All cases were reclassified according to ...

journal_title：Biological psychiatry

authors： Small JG,Milstein V,Sharpley PH,Klapper M,Small IF

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:As observed in depressed adults, there is considerable variability in the degree and direction of hypothalamic-pituitary-adrenal (HPA) dysfunction in depressed adolescents. The variability in HPA findings may be attributed to experiential factors. METHODS:A modified version of a standard psychosocial stress...

journal_title：Biological psychiatry

authors： Rao U,Hammen C,Ortiz LR,Chen LA,Poland RE

更新日期：2008-09-15 00:00:00

abstract：:Parental stress exposures are implicated in the risk for offspring neurodevelopmental and neuropsychiatric disorders, prompting critical examination of preconception and prenatal periods as vulnerable to environmental insults such as stress. Evidence from human studies and animal models demonstrates the influence that...

journal_title：Biological psychiatry

authors： Chan JC,Nugent BM,Bale TL

更新日期：2018-05-15 00:00:00

abstract：BACKGROUND:The incubation of cue-induced drug craving in rodents provides a model of persistent vulnerability to craving and relapse in human addicts. After prolonged withdrawal, incubated cocaine craving depends on strengthening of nucleus accumbens (NAc) core synapses through incorporation of Ca2+-permeable alpha-ami...

journal_title：Biological psychiatry

authors： Scheyer AF,Loweth JA,Christian DT,Uejima J,Rabei R,Le T,Dolubizno H,Stefanik MT,Murray CH,Sakas C,Wolf ME

更新日期：2016-11-01 00:00:00

abstract：:This study evaluated electrophysiological (EEG, ERGs), and cognitive (neuropsychological testing) responses in patients with late luteal phase dysphoric disorder (LLPDD, DSM-III-R) and controls over the menstrual cycle. In both groups, the frequency and stability of electroencephalogram (EEG) alpha activity significan...

journal_title：Biological psychiatry

authors： Ehlers CL,Phillips E,Parry BL

更新日期：1996-04-15 00:00:00

abstract：:To explore possible disturbances of cerebral monoamines linked to glucose metabolism, 18 schizophrenics, 21 neurotics, and 21 controls were given a 5-hr glucose tolerance test, and the effect of the glucose load on total and free tryptophan, insulin, and free fatty acids in serum was studied in medication-free patient...

journal_title：Biological psychiatry

authors： Yaryura-Tobias JA,Chang A,Neziroglu F

更新日期：1978-04-01 00:00:00

abstract：:Elderly depressed patients who met the research diagnostic criteria (RDC) for major depressive illness, resistant to other types of treatment, were treated with phenelzine, a nonselective monoamine oxidase (MAO) inhibitor, for a period of 2 to 7 weeks, following 2 weeks of placebo washout period. Dosage ranged from 15...

journal_title：Biological psychiatry

authors： Georgotas A,Friedman E,McCarthy M,Mann J,Krakowski M,Siegel R,Ferris S

更新日期：1983-02-01 00:00:00

abstract：:In order to evaluate the impact of aging on EEG sleep patterns we investigated the polysomnograms of 74 patients with major depression and 51 healthy volunteers aged 18-65 years. In most of the EEG sleep parameters, age-related changes were obvious in both the depressives and the normals. In the patients, some of thes...

journal_title：Biological psychiatry

authors： Lauer CJ,Riemann D,Wiegand M,Berger M

更新日期：1991-05-15 00:00:00

abstract：BACKGROUND:The val66met variant located within the brain-derived neurotrophic factor gene (BDNF) has previously been associated with human neuroticism, a dimension of personality strongly predictive of depressive illness. METHODS:Here we report an attempt to replicate this association using three populations of extrem...

journal_title：Biological psychiatry

authors： Willis-Owen SA,Fullerton J,Surtees PG,Wainwright NW,Miller S,Flint J

更新日期：2005-11-01 00:00:00

abstract：:The aim of the present paper was to perform a single trial analysis of event-related potentials in order to elucidate the mechanisms behind a reduced P300 amplitude occurring in unmedicated depressives (n = 11) and schizophrenics (n = 18). For this purpose, tools from linear system theory were applied to single trials...

journal_title：Biological psychiatry

authors： Röschke J,Wagner P,Mann K,Fell J,Grözinger M,Frank C

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Psychological stress and trauma are risk factors for several medical and psychiatric illnesses. Recent studies have implicated advanced cellular aging as a potential mechanism of this association. Telomeres, DNA repeats that cap the ends of chromosomes and promote stability, shorten progressively with each c...

journal_title：Biological psychiatry

authors： Tyrka AR,Price LH,Kao HT,Porton B,Marsella SA,Carpenter LL

更新日期：2010-03-15 00:00:00

abstract：BACKGROUND:The aim of the present study was to investigate dopamine synthesis in the brain of drug-free schizophrenic patients, not only in the striatum but also in extrastriatal areas like the prefrontal cortex, brain areas that for a long time has been in focus of interest in the pathophysiology of schizophrenia. ME...

journal_title：Biological psychiatry

authors： Lindström LH,Gefvert O,Hagberg G,Lundberg T,Bergström M,Hartvig P,Långström B

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Current smoking cessation therapies offer limited success, as relapse rates remain high. Nicotine, which is the major component of tobacco smoke, is thought to be primarily responsible for the addictive properties of tobacco. However, little is known about the molecular mechanisms underlying nicotine relapse...

journal_title：Biological psychiatry

authors： Lubbers BR,van Mourik Y,Schetters D,Smit AB,De Vries TJ,Spijker S

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:A parallel downregulation of brain-derived neurotrophic factor (BDNF) and somatostatin (SST), a marker of inhibitory gamma-aminobutyric acid interneurons that target pyramidal cell dendrites, has been reported in several brain areas of subjects with major depressive disorder (MDD). Rodent genetic studies sug...

journal_title：Biological psychiatry

authors： Oh H,Piantadosi SC,Rocco BR,Lewis DA,Watkins SC,Sibille E

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:The cognitive deficits of schizophrenia are largely resistant to current treatments and thus are a lifelong illness burden. The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) provides a reliable and valid assessment of cognition across ma...

journal_title：Biological psychiatry

authors： Sui J,Pearlson GD,Du Y,Yu Q,Jones TR,Chen J,Jiang T,Bustillo J,Calhoun VD

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Subjects with autism suffer from impairments of social interaction, deviations in language usage, as well as restricted and stereotyped patterns of behavior. These characteristics are found irrespective of age, IQ, and gender of affected subjects. However, brain changes due to age, IQ, and gender might pose ...

journal_title：Biological psychiatry

authors： Kurth F,Narr KL,Woods RP,O'Neill J,Alger JR,Caplan R,McCracken JT,Toga AW,Levitt JG

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Gray and white matter volume deficits have been reported in many structural magnetic resonance imaging (MRI) studies of children with attention-deficit/hyperactivity disorder (ADHD); however, there is a paucity of structural MRI studies of adults with ADHD. This study used voxel based morphometry and applied...

journal_title：Biological psychiatry

authors： Seidman LJ,Biederman J,Liang L,Valera EM,Monuteaux MC,Brown A,Kaiser J,Spencer T,Faraone SV,Makris N

更新日期：2011-05-01 00:00:00

abstract：:Mood disorders are the leading causes of morbidity and mortality in children and adolescence. As a result, many adolescents are treated with psychopharmacologic agents such as antidepressants and mood stabilizers. To date, research into the safety and efficacy of these medications has lagged behind clinical practice. ...

journal_title：Biological psychiatry

authors： Emslie GJ,Mayes TL

更新日期：2001-06-15 00:00:00

abstract：BACKGROUND:The prodromal phase of schizophrenic disorders has been described prospectively. The present study aimed to determine the short-term efficacy and safety of olanzapine treatment of prodromal symptoms compared with placebo. METHODS:This was a double-blind, randomized, parallel-groups, placebo-controlled trial...

journal_title：Biological psychiatry

authors： Woods SW,Breier A,Zipursky RB,Perkins DO,Addington J,Miller TJ,Hawkins KA,Marquez E,Lindborg SR,Tohen M,McGlashan TH

更新日期：2003-08-15 00:00:00

abstract：BACKGROUND:Plasma cortisol, beta-endorphin, corticotropin, corticotropin-releasing factor, and salivary cortisol concentrations, resting and after ingestion of 1 mg of dexamethasone, were investigated in depressed patients and controls. METHODS:Fourteen outpatients from the psychiatric department diagnosed with depres...

journal_title：Biological psychiatry

authors： Galard R,Catalán R,Castellanos JM,Gallart JM

更新日期：2002-03-15 00:00:00

abstract：:Magnetic resonance spectroscopy allows investigation of in vivo neurochemical pathology of schizophrenia. "First generation" studies, focusing on phosphorus and proton magnetic resonance spectroscopy, have suggested alterations in membrane phospholipid metabolism and reductions in N-acetyl aspartate in the frontal and...

journal_title：Biological psychiatry

authors： Keshavan MS,Stanley JA,Pettegrew JW

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Relations between stress hormones and antisocial behavior are understudied. METHODS:A subsample (n = 335) of at-risk males recruited in first grade for a longitudinal study were recruited at approximately 16 years of age for a laboratory study, including two psychological challenges: describing their worst ...

journal_title：Biological psychiatry

authors： McBurnett K,Raine A,Stouthamer-Loeber M,Loeber R,Kumar AM,Kumar M,Lahey BB

更新日期：2005-05-15 00:00:00

abstract：:This paper is not a comprehensive review of the literature. Rather, it is a viewpoint based upon advances in other fields of medicine and genetics that may provide a model for guiding research in psychiatry. The paper discusses the major limitations of the medicines currently used to treat schizophrenia and bipolar il...

journal_title：Biological psychiatry

authors： Scolnick EM

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Bipolar disorder is associated with functional and structural abnormalities in the brain circuits involved in processing emotional stimuli. Although impairments of cognitive function have been found to persist in bipolar patients during periods of euthymic mood, it is not known whether abnormalities in emoti...

journal_title：Biological psychiatry

authors： Harmer CJ,Grayson L,Goodwin GM

更新日期：2002-02-15 00:00:00

abstract：:The volume of the entorhinal region is significantly reduced in postmortem brains of schizophrenics compared with controls (p less than 0.017). In addition, a significant reduction of neurons (p less than 0.017), but no significant increase in absolute glial cell numbers, is found. These results are consistent with th...

journal_title：Biological psychiatry

authors： Falkai P,Bogerts B,Rozumek M

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:We recently described a preliminary association between the hypofunctional seven-repeat allele of the dopamine-4 receptor gene (DRD4) and increased maximal lifetime body mass index in women with seasonal affective disorder (SAD). In this study, we examined whether binge eating behavior mediated this putative...

journal_title：Biological psychiatry

authors： Levitan RD,Masellis M,Basile VS,Lam RW,Kaplan AS,Davis C,Muglia P,Mackenzie B,Tharmalingam S,Kennedy SH,Macciardi F,Kennedy JL

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Childhood-onset schizophrenia (COS), defined as onset of psychotic symptoms by age 12 years, is a rare and severe form of the disorder that seems to be clinically and neurobiologically continuous with the adult disorder. METHODS:We studied a rare cohort consisting of 98 probands; 71 of these probands receiv...

journal_title：Biological psychiatry

authors： Addington AM,Gornick M,Sporn AL,Gogtay N,Greenstein D,Lenane M,Gochman P,Baker N,Balkissoon R,Vakkalanka RK,Weinberger DR,Straub RE,Rapoport JL

更新日期：2004-05-15 00:00:00

abstract：BACKGROUND:In addition to cognitive impairment, there are disruptions to mood and emotion processing in attention-deficit/hyperactivity disorder (ADHD) but little is known about their neural basis. We examined ADHD disturbances in mood and emotion recognition and underlying neural systems before and after treatment wit...

journal_title：Biological psychiatry

authors： Williams LM,Hermens DF,Palmer D,Kohn M,Clarke S,Keage H,Clark CR,Gordon E

更新日期：2008-05-15 00:00:00