Diminished gray matter within the hypothalamus in autism disorder: a potential link to hormonal effects?

Abstract:

BACKGROUND:Subjects with autism suffer from impairments of social interaction, deviations in language usage, as well as restricted and stereotyped patterns of behavior. These characteristics are found irrespective of age, IQ, and gender of affected subjects. However, brain changes due to age, IQ, and gender might pose potential confounds in autism neuroimaging analyses. METHODS:To investigate gray matter differences in autism that are not related to these potential confounds, we performed a voxel-based morphometry analysis in 52 affected children and adolescents and 52 matched control subjects. RESULTS:We observed diminished gray matter in a region of the hypothalamus, which synthesizes the behaviorally relevant hormones oxytocin and arginine vasopressin. CONCLUSIONS:This finding provides support for further investigations of the theory of abnormal functioning of this hormonal system in autism and potentially for experimental therapeutic approaches with oxytocin and related neuropeptides.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Kurth F,Narr KL,Woods RP,O'Neill J,Alger JR,Caplan R,McCracken JT,Toga AW,Levitt JG

doi

10.1016/j.biopsych.2011.03.026

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

278-82

issue

3

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(11)00276-9

journal_volume

70

pub_type

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