Abstract：
:Several studies have demonstrated that the great majority of Alzheimer's disease (AD) patients suffer "noncognitive" neuropsychiatric symptoms. Depression is one of the most frequent neuropsychiatric comorbidities of AD. Affecting up to 50% of AD patients, depression in AD is associated with serious negative consequences for patients and their caregivers. Yet available studies on the natural course, etiology, and treatment of depression in AD have been few and equivocal. Heterogeneity in research methodology and etiology of depression in AD might have contributed to inconsistent findings across studies. Recently, the National Institute of Mental Health (NIMH) convened the Depression of Alzheimer's Disease Workgroup, which proposed provisional diagnostic criteria for depression of Alzheimer's Disease (NIMH-dAD). These criteria may provide a framework for future studies to clarify the unresolved issues in nosology, etiology, and treatment of depression in AD. A longitudinal cohort study of depression in incident AD cases may provide further syndrome refinement that would facilitate investigation of the etiology and treatment of depression in AD.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Lee HB,Lyketsos CGdoi
10.1016/s0006-3223(03)00543-2subject
Has Abstractpub_date
2003-08-01 00:00:00pages
353-62issue
3eissn
0006-3223issn
1873-2402pii
S0006322303005432journal_volume
54pub_type
杂志文章,评审abstract：:Twenty-eight psychiatric patients with computerized tomography (CT) findings of ventricular abnormality most likely to result from prenatal/perinatal lesions (VA group) were compared to 28 sex- and age-matched psychiatric patients with normal neuroradiological findings (NCT group). The neuroradiological rater was blin...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0006-3223(95)00623-0
更新日期：1996-12-15 00:00:00
abstract：BACKGROUND:Gamma-aminobutyric acid (GABA)-ergic function is altered in schizophrenia. Of particular interest is the altered central nervous system expression of GABA-A receptor subunits, as changes in subunit expression account for recognized differences in mammalian brain function making them inviting targets for nove...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.09.017
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Children with early-onset disruptive behavior disorder (DBD), especially those with callous-unemotional traits, are at risk of developing persistent and severe adult antisocial behavior. One possible underlying mechanism for persistence is deficient reward and loss sensitivity, i.e., deficient incentive proc...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2014.08.017
更新日期：2015-11-01 00:00:00
abstract：:Obsessive-compulsive disorder (OCD) affects 2%-3% of the population worldwide and can cause significant distress and disability. Substantial challenges remain in the field of OCD research and therapeutics. Approved interventions alleviate symptoms only partially, with 30%-40% of patients being resistant to treatment. ...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2015.04.020
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Current neuroimaging perspectives on a variety of mental disorders emphasize dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the regulation of social cognition and behavior, accumulates in cerebrospinal fluid after intranasal administration in macaques and humans and modulates...
journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.biopsych.2017.04.015
更新日期：2017-12-15 00:00:00
abstract：:Opponent processes have long been known to be a basic building block of neural circuits. This article describes properties of opponent processes in which phasic cues and tonic arousal are gated by slowly accumulating chemical transmitters. These opponent processes are called gated dipoles. Gated dipole circuits exhibi...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1984-07-01 00:00:00
abstract：BACKGROUND:Although genetic risk factors for posttraumatic stress disorder (PTSD) in similarly traumatized cohorts can be confounded with risk for type of exposure, the primary risk for exposure to the 9/11 attack on New York City was proximity, allowing study of PTSD risk in a sample that is not confounded by exposure...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.02.034
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:Identifying beneficial surrogate genetic markers in psychiatric disorders is crucial but challenging. METHODS:Given that scalp hair follicles are easily accessible and, like the brain, are derived from the ectoderm, expressions of messenger RNA (mRNA) and microRNA in the organ were examined between schizoph...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2014.07.025
更新日期：2015-07-15 00:00:00
abstract：BACKGROUND:Obsessive-compulsive disorder (OCD) is a psychiatric condition that typically manifests in compulsive urges to perform irrational or excessive avoidance behaviors. A recent account has suggested that compulsivity in OCD might arise from excessive stimulus-response habit formation, rendering behavior insensit...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2013.02.002
更新日期：2014-04-15 00:00:00
abstract：:In order to evaluate the impact of aging on EEG sleep patterns we investigated the polysomnograms of 74 patients with major depression and 51 healthy volunteers aged 18-65 years. In most of the EEG sleep parameters, age-related changes were obvious in both the depressives and the normals. In the patients, some of thes...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90355-p
更新日期：1991-05-15 00:00:00
abstract：:To examine the nature of impaired smooth pursuit eye movement (SPEM) in schizophrenia, 16 hospitalized schizophrenics in the acute phase and 16 hospitalized nonpsychotic patients were studied. The experiment consisted of five 30-sec visual tracking phases: (i) base line (no distraction); (ii) auditory-visual distracti...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1978-10-01 00:00:00
abstract：BACKGROUND:The development of adaptive implicit and explicit emotion regulation skills is crucial for mental health. Adolescence and emerging adulthood are periods of heightened risk for psychopathology associated with emotion dysregulation, and neurodevelopmental mechanisms have been proposed to account for this incre...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2020.08.006
更新日期：2021-01-15 00:00:00
abstract：BACKGROUND:Autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD) are associated with complex changes as revealed by functional magnetic resonance imaging. To date, neuroimaging-based models are not able to characterize individuals with sufficient sensitivity and specificity. Further, although evi...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2019.02.019
更新日期：2019-08-15 00:00:00
abstract：BACKGROUND:The DBH gene regulates plasma dopamine beta-hydroxylase activity (pDbetaH). Two single nucleotide polymorphisms (SNPs), -1021C-->T (rs1611115; SNP1) and +1603C-->T (rs6271; SNP3), independently influence pDbetaH. Another SNP, commonly known as DBH Taq1A (rs2519152; SNP2) is associated with attention-deficit/...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.02.017
更新日期：2006-11-15 00:00:00
abstract：BACKGROUND:Volumetric imaging research has shown abnormal brain morphology in adults with posttraumatic stress disorder (PTSD) when compared with matched control subjects. In this article, we present brain imaging findings from a study of children with PTSD symptoms. METHODS:Twenty-four children between the ages of 7 ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(01)01218-5
更新日期：2001-12-15 00:00:00
abstract：:Accumulating evidence supports the view that deregulation of the immune system represents an important vulnerability factor for psychosis. In a subgroup of psychotic patients, the high comorbidity with autoimmune and chronic inflammatory conditions suggests a common underlying immune abnormality leading to both condit...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2013.09.037
更新日期：2014-02-15 00:00:00
abstract：:Social phobia (or "social anxiety disorder") is a prevalent condition that has been the subject of increased scrutiny in recent years. The purpose of this paper is to review the neurobiology of social phobia. It is apparent from the extant literature that this disorder is poorly understood from a neurobiological persp...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(98)00265-0
更新日期：1998-12-15 00:00:00
abstract：BACKGROUND:A novel, high-affinity (.7-2.0 nmol) compound that selectively activates the alpha2, alpha 3, and alpha 5 (but not alpha1) gamma-aminobutyric acid-A (GABA(A)) receptor subtypes, TPA023B (2',6-difluoro-5'-[3-(1-hydroxy-1-methylethyl) imidazo[1,2-b][1,2,4]triazin-7-yl][1,1'-biphenyl]-2-carbonitrile) was pharma...
journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.biopsych.2008.01.021
更新日期：2008-07-15 00:00:00
abstract：:This review was generated from discussions by the Pharmacologic and Somatic Treatments Section of the National Institute of Mental Health Strategic Plan for Mood Disorders Committee on advancing novel pharmacologic and somatic treatments for mood disorders. The opening section of the article summarizes in broad stroke...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(02)01470-1
更新日期：2002-09-15 00:00:00
abstract：BACKGROUND:Difficulty with impulse control is heightened in children with a family history of alcohol use disorders and is a risk factor for later substance problems. Cross-sectional functional magnetic resonance imaging studies have shown altered impulse control processing in adolescents with a positive family history...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2014.03.005
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Fragile X syndrome (FXS) is the most common known heritable cause of intellectual disability. Prior studies in FXS have observed a plateau in cognitive and adaptive behavioral development in early adolescence, suggesting that brain development in FXS may diverge from typical development during this period. ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2011.05.038
更新日期：2011-11-01 00:00:00
abstract：:This paper reviews and correlates three separate recent findings that implicate the one-carbon cycle in neuropsychiatric disease: (i) the demonstration by kinetic studies that the Vmax of methionine adenosine transferase (MAT) is reduced in some schizophrenics and depressives and is increased in some manics, and that ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
abstract：:The APOE genotypes of 45 elderly inpatients with major depression were determined to investigate the relationship of this disorder to irreversible dementia in late life. We specifically tested the hypothesis that the frequency of the APOE epsilon 4 allele is elevated in depressed elders with cognitive impairment or ps...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(96)00046-7
更新日期：1996-11-15 00:00:00
abstract：:Elevated plasma vasopressin concentrations have been documented in antipsychotic drug-treated patients as well as a drug-free acutely psychotic patients. To evaluate the effects of antipsychotic drugs on plasma vasopressin, we measured vasopressin response to a single dose of intramuscular chlorpromazine or intravenou...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(87)90167-3
更新日期：1987-04-01 00:00:00
abstract：BACKGROUND:Women are overrepresented in samples of patients with rapid cycling bipolar disorder (RCBD). To explore whether menstrually related mood changes might account for this gender difference, we studied the relationship between menstrual cycle phase and mood in a sample of premenopausal women with rapid cycling b...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(99)00023-2
更新日期：1999-08-15 00:00:00
abstract：BACKGROUND:Noradrenergic function has been linked to posttraumatic stress disorder (PTSD) and might have a role in mediating sleep disturbances of the disorder. Our objective was to relate a peripheral manifestation of noradrenergic function, sympathetic nervous system activity as indexed by heart rate variability duri...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2003.12.018
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:QTc interval prolongation can occur as a result of treatment with both conventional and novel antipsychotic medications and is of clinical concern because of its association with the potentially fatal ventricular arrhythmia, torsade de pointes. METHODS:One case is described in which a patient with schizophr...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(01)01333-6
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:Recent evidence indicates that individuals who are homozygous for the short (s) allele in the promoter region of the serotonin transporter gene have higher rates of depression and other psychiatric disorders as a function of exposure to increasing levels of stressful life events than do individuals who have ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.10.008
更新日期：2008-05-01 00:00:00
abstract：:The effect of nortriptyline was assessed on the EEG sleep of 20 inpatients with major depressive syndrome. While 25 mg of nortriptyline had an immediate effect on REM sleep variables, relatively little influence on sleep continuity measures was noted. Subsequent administration of 75 and 100 mg of nortriptyline produce...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1982-05-01 00:00:00
abstract：BACKGROUND:The hippocampus (HC) is smaller in patients with recurrent major depressive disorder (MDD), but few longitudinal studies have examined whether volume is associated with clinically meaningful outcomes such as response to treatment. METHODS:We compared regional (head and body/tail) HC volumes in 46 patients w...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.06.027
更新日期：2008-11-15 00:00:00
