Some normal and abnormal behavioral syndromes due to transmitter gating of opponent processes.

abstract：BACKGROUND:Williams syndrome (WS), a genetic disorder resulting from hemizygous microdeletion of chromosome 7q11.23, has emerged as a model for identifying the genetic architecture of socioemotional behavior. Common polymorphisms in GTF2I, which is found within the WS microdeletion, have been associated with reduced so...

journal_title：Biological psychiatry

authors： Swartz JR,Waller R,Bogdan R,Knodt AR,Sabhlok A,Hyde LW,Hariri AR

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Pharmacological evidence support that enhancement of serotonin (5-HT) neurotransmission is critical for treatment efficacy in obsessive-compulsive disorder (OCD). Surprisingly, acute tryptophan depletion (ATD), a procedure known to reduce 5-HT neurotransmission, carried out in remitted OCD patients on select...

journal_title：Biological psychiatry

authors： Berney A,Sookman D,Leyton M,Young SN,Benkelfat C

更新日期：2006-05-01 00:00:00

abstract：:Anxious patients, and more specifically, patients experiencing panic attacks, are thought to have a significant biological component to their illness. This study looks at two promising biological markers associated with this patient population-mitral valve prolapse and lactate-induced panic. We present our findings, w...

journal_title：Biological psychiatry

authors： Dager SR,Cowley DS,Dunner DL

更新日期：1987-03-01 00:00:00

abstract：:Patients with chronic hypercortisolemia due to Cushing's syndrome (CS) exhibit cognitive dysfunction. Because glucocorticoid excess is associated with hippocampal damage in animals, and the hippocampus participates in learning and memory, we explored the relationships between hippocampal formation (HF) volume, memory ...

journal_title：Biological psychiatry

authors： Starkman MN,Gebarski SS,Berent S,Schteingart DE

更新日期：1992-11-01 00:00:00

abstract：:It has been suggested that the signs and symptoms of the ethanol withdrawal syndrome may be due to the increased production of an "inverse agonist" that binds to the central benzodiazepine (BZ) recognition site in the brain. Ro 15-1788 (a potent antagonist at the central BZ recognition site), diazepam, and Ro 15-1788 ...

journal_title：Biological psychiatry

authors： Adinoff B,Majchrowicz E,Martin PR,Linnoila M

更新日期：1986-06-01 00:00:00

abstract：:Positron emission tomography (PET) measurements of cerebral glucose use were made in 18 patients with generalized anxiety disorder (GAD) during a passive viewing task off medication, and an active vigilance viewing task before and after medication or placebo treatment. In the passive viewing task, patients with GAD we...

journal_title：Biological psychiatry

authors： Wu JC,Buchsbaum MS,Hershey TG,Hazlett E,Sicotte N,Johnson JC

更新日期：1991-06-15 00:00:00

abstract：:This overview describes the generation and development of the ideas that led to the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative. It also describes the organization, process, and products of the first meeting. The CNTRICS initiative involves a series of three con...

journal_title：Biological psychiatry

authors： Carter CS,Barch DM,Buchanan RW,Bullmore E,Krystal JH,Cohen J,Geyer M,Green M,Nuechterlein KH,Robbins T,Silverstein S,Smith EE,Strauss M,Wykes T,Heinssen R

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Previous neuroimaging studies have demonstrated exaggerated amygdala responses to negative stimuli in posttraumatic stress disorder (PTSD). The time course of this amygdala response is largely unstudied and is relevant to questions of habituation and sensitization in PTSD exposure therapy. METHODS:We applie...

journal_title：Biological psychiatry

authors： Protopopescu X,Pan H,Tuescher O,Cloitre M,Goldstein M,Engelien W,Epstein J,Yang Y,Gorman J,LeDoux J,Silbersweig D,Stern E

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Cannabis use is associated with an increased risk of psychosis. One study has suggested that genetic variation in the AKT1 gene might influence this effect. METHODS:In a case-control study of 489 first-episode psychosis patients and 278 control subjects, we investigated the interaction between variation at ...

journal_title：Biological psychiatry

authors： Di Forti M,Iyegbe C,Sallis H,Kolliakou A,Falcone MA,Paparelli A,Sirianni M,La Cascia C,Stilo SA,Marques TR,Handley R,Mondelli V,Dazzan P,Pariante C,David AS,Morgan C,Powell J,Murray RM

更新日期：2012-11-15 00:00:00

abstract：:The smooth pursuit responses to 5 degrees and 20 degrees/sec constant-velocity stimuli were recorded from 23 patients with schizophrenia, 16 affective disorder patients, and 21 normals using low-noise infrared oculography. Pursuit gain, catch-up saccade (CUS) rate and amplitude, and their interrelationships were exami...

journal_title：Biological psychiatry

authors： Abel LA,Friedman L,Jesberger J,Malki A,Meltzer HY

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:DISC1 has been suggested as a causative gene for psychoses in a large Scottish kindred. PCNT2 has recently been identified as an interacting partner of DISC1. In this study, we investigated the role of PCNT2 in bipolar disorder, by gene expression analysis and genetic association study. METHODS:By TaqMan re...

journal_title：Biological psychiatry

authors： Anitha A,Nakamura K,Yamada K,Iwayama Y,Toyota T,Takei N,Iwata Y,Suzuki K,Sekine Y,Matsuzaki H,Kawai M,Miyoshi K,Katayama T,Matsuzaki S,Baba K,Honda A,Hattori T,Shimizu S,Kumamoto N,Tohyama M,Yoshikawa T,Mori N

更新日期：2008-04-01 00:00:00

abstract：:A group of 231 psychiatric patients were evaluated (with the Wechsler Adult Intelligence Scale and the Halstead-Reitan Neuropsychological Test Battery) before and after electroconvulsive therapy. Improvement during the course of therapy was shown in 96% of the measures and significant improvement (p less than 0.05) oc...

journal_title：Biological psychiatry

authors： Malloy FW,Small IF,Miller MJ,Milstein V,Stout JR

更新日期：1982-01-01 00:00:00

abstract：:Federal regulations governing human subjects research call for additional protections for the "mentally disabled." However, there is currently no consensus definition of mental disability or guidelines for how these research subjects should be protected. This ambiguity complicates the work of institutional review boar...

journal_title：Biological psychiatry

authors： Rosenstein DL

更新日期：1999-10-15 00:00:00

abstract：BACKGROUND:Schizophrenia patients exhibit impairment in prepulse inhibition (PPI) of the acoustic startle response (ASR), suggesting a sensorimotor gating deficit. The serotonin-2A receptor (5-HT(2A)R) has been implicated in both the pathogenesis of schizophrenia and the PPI deficits of schizophrenia patients. Moreover...

journal_title：Biological psychiatry

authors： Quednow BB,Kühn KU,Mössner R,Schwab SG,Schuhmacher A,Maier W,Wagner M

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Two Wistar rat lines selectively bred for either high (HAB) or low (LAB) anxiety-related behavior were used to identify neurobiological correlates of trait anxiety. METHODS:We used Fos expression for mapping of neuronal activation patterns in response to mild anxiety-provoking challenges. RESULTS:In both l...

journal_title：Biological psychiatry

authors： Salomé N,Salchner P,Viltart O,Sequeira H,Wigger A,Landgraf R,Singewald N

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Results on the association between depression and the hypothalamo-pituitary-adrenal (HPA) axis have been inconsistent, possibly due to heterogeneity of the DSM-IV category of depression. Specific symptom-dimensions could be used as a more homogenous phenotype in HPA-axis research. METHODS:Subjects (n = 1029...

journal_title：Biological psychiatry

authors： Wardenaar KJ,Vreeburg SA,van Veen T,Giltay EJ,Veen G,Penninx BW,Zitman FG

更新日期：2011-02-15 00:00:00

abstract：:Converging lines of evidence suggest a role for the mesolimbic dopamine system in the response to somatic antidepressant therapies. Here, we review evidence suggesting that antidepressant treatments of different types share the effect of increasing the sensitivity of dopamine D2-like receptors in the nucleus accumbens...

journal_title：Biological psychiatry

authors： Gershon AA,Vishne T,Grunhaus L

更新日期：2007-01-15 00:00:00

abstract：BACKGROUND:Pediatric anxiety disorders involve greater capture of attention by threatening stimuli. However, it is not known if disturbances extend to nonthreatening stimuli, as part of a pervasive disturbance in attention-related brain systems. We hypothesized that pediatric anxiety involves greater capture of attenti...

journal_title：Biological psychiatry

authors： Perino MT,Yu Q,Myers MJ,Harper JC,Baumel WT,Petersen SE,Barch DM,Luby JL,Sylvester CM

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:There is evidence of abnormal cerebral dopamine transmission in nicotine-dependent smokers, but it is unclear whether dopaminergic abnormalities are due to acute nicotine abuse or whether they persist with abstinence. We addressed this question by conducting longitudinal positron emission tomography (PET) ex...

journal_title：Biological psychiatry

authors： Rademacher L,Prinz S,Winz O,Henkel K,Dietrich CA,Schmaljohann J,Mohammadkhani Shali S,Schabram I,Stoppe C,Cumming P,Hilgers RD,Kumakura Y,Coburn M,Mottaghy FM,Gründer G,Vernaleken I

更新日期：2016-08-01 00:00:00

abstract：:This review was generated from discussions by the Pharmacologic and Somatic Treatments Section of the National Institute of Mental Health Strategic Plan for Mood Disorders Committee on advancing novel pharmacologic and somatic treatments for mood disorders. The opening section of the article summarizes in broad stroke...

journal_title：Biological psychiatry

authors： Tamminga CA,Nemeroff CB,Blakely RD,Brady L,Carter CS,Davis KL,Dingledine R,Gorman JM,Grigoriadis DE,Henderson DC,B Innis RB,Killen J,Laughren TP,McDonald WM,M Murphy GM Jr,Paul SM,Rudorfer MV,Sausville E,Schatzberg AF

更新日期：2002-09-15 00:00:00

abstract：BACKGROUND:Morphometric magnetic resonance imaging (MRI) studies of pediatric bipolar disorder (BD) have not reported on gray matter volumes but have reported increased lateral ventricular size and presence of white matter hyperintensities (WMH). We studied gray matter volume, ventricular-to-brain ratios (VBR), and num...

journal_title：Biological psychiatry

authors： Chang K,Barnea-Goraly N,Karchemskiy A,Simeonova DI,Barnes P,Ketter T,Reiss AL

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Buprenorphine (BUP) is effective in the treatment of opioid dependence when given on alternating days, probably as a result of long-lasting occupation of micro opioid receptors (microORs). This study examined the duration of action of BUP at microORs and correlations with pharmacokinetic and pharmacodynamic ...

journal_title：Biological psychiatry

authors： Greenwald M,Johanson CE,Bueller J,Chang Y,Moody DE,Kilbourn M,Koeppe R,Zubieta JK

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The neural projections from the infralimbic region of the prefrontal cortex to the amygdala are important for the maintenance of conditioned fear extinction. Neurons in this pathway exhibit a unique pattern of structural plasticity that is sex-dependent, but the relationship between the morphologic character...

journal_title：Biological psychiatry

authors： Gruene TM,Roberts E,Thomas V,Ronzio A,Shansky RM

更新日期：2015-08-01 00:00:00

abstract：:Animal models of social isolation have been suggested to be relevant to several neuropsychiatric disorders; however, social isolation is usually not purely an alteration of social environment, as it often involves such factors as decreased complexity of the environment, loss of tactile stimulation, and increased metab...

journal_title：Biological psychiatry

authors： Kim JW,Kirkpatrick B

更新日期：1996-11-01 00:00:00

abstract：:Unmedicated chronic schizophrenic inpatients and nonpsychotic controls were tested in a paradigm designed to elicit habituated event-related potentials (ERPs) to auditory stimuli. Analysis of Variance of the ERP components recorded at bilateral frontal (F1 and F2) and temporal (T3 and T4) scalp leads revealed signific...

journal_title：Biological psychiatry

authors： Kessler C,Steinberg A

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Chromium picolinate (CP) has been reported to benefit patients with symptoms of atypical depression. METHODS:A placebo-controlled, double-blind, pilot study of CP was conducted in 15 patients with DSM-IV major depressive disorder, atypical type. Patients received 600 micro g of CP or matching placebo (PBO) ...

journal_title：Biological psychiatry

authors： Davidson JR,Abraham K,Connor KM,McLeod MN

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:The study of Turner syndrome (TS) offers a unique window of opportunity for advancing scientific knowledge of how X chromosome gene imprinting, epigenetic factors, hormonal milieu, and chronologic age affect brain development in females. METHODS:We described brain growth trajectories in 55 girls with TS and...

journal_title：Biological psychiatry

authors： O'Donoghue S,Green T,Ross JL,Hallmayer J,Lin X,Jo B,Huffman LC,Hong DS,Reiss AL

更新日期：2020-01-15 00:00:00

abstract：:Prominent heightened arousal symptoms and clinical/laboratory findings implicate the central noradrenergic system in posttraumatic stress disorder (PTSD). Heightened arousal frequently manifests in relation to sleep in PTSD. Central noradrenergic systems have a role in regulating arousal levels during sleep. We theref...

journal_title：Biological psychiatry

authors： Mellman TA,Kumar A,Kulick-Bell R,Kumar M,Nolan B

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Pregnancy and the postpartum period are a time of increased risk for women to develop mood disorders. As such, the reproductive safety data on antidepressant use during pregnancy have rapidly expanded over the last decade; however, there is relatively sparse information on maternal/fetal exchange of these me...

journal_title：Biological psychiatry

authors： Hostetter A,Ritchie JC,Stowe ZN

更新日期：2000-11-15 00:00:00

abstract：:In a sample of 13 endogenous depressive inpatients, REM (rapid eye movement) latency (recorded over 4 consecutive nights after 2 habituation nights) and contingent negative variation amplitude showed significant relationship, suggesting that both parameters may depend on the same mechanisms, possibly cholinergic. ...

journal_title：Biological psychiatry

authors： Ansseau M,Machowski R,Franck G,Timsit-Berthier M

更新日期：1985-12-01 00:00:00