Abstract：
BACKGROUND:Pregnancy and the postpartum period are a time of increased risk for women to develop mood disorders. As such, the reproductive safety data on antidepressant use during pregnancy have rapidly expanded over the last decade; however, there is relatively sparse information on maternal/fetal exchange of these medications and no data reporting their concentrations in amniotic fluid. METHODS:We report on three women treated during pregnancy with fluvoxamine, sertraline, and venlafaxine, respectively. Amniotic fluid at amniocentesis and umbilical cord blood and maternal blood at delivery were collected and analyzed for antidepressant concentrations using high performance liquid chromatography with UV detection. RESULTS:Antidepressant and metabolite concentrations were detectable in all amniotic fluid samples, though parent compound concentrations were less than maternal serum and umbilical cord blood concentrations. No adverse effects of the medication were reported. CONCLUSIONS:The presence of these antidepressants in amniotic fluid suggests that fetal exposure to these medications is continual and may occur through a variety of paths, thus accounting for increased fetal exposure. These paths include circulatory via placental passage, gastrointestinal via fetal swallowing, and respiratory secondary to fetal lung absorption.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Hostetter A,Ritchie JC,Stowe ZNdoi
10.1016/s0006-3223(00)00958-6subject
Has Abstractpub_date
2000-11-15 00:00:00pages
1032-4issue
10eissn
0006-3223issn
1873-2402pii
S0006-3223(00)00958-6journal_volume
48pub_type
杂志文章abstract：:The relationship between plasma kynurenine (KYN) concentration and anxiety and depression in psychiatric patients was examined. KYN has been reported as a probable endogenous anxiogen in animal models of anxiety. Thirty patients with affective states were studied. The Hamilton Anxiety Scale (HAM-A), Hamilton Depressio...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/0006-3223(94)91189-4
更新日期：1994-07-15 00:00:00
abstract：BACKGROUND:Ventral tegmental area (VTA) brain-derived neurotrophic factor (BDNF) contributes to time-dependent increases in cue-induced cocaine seeking after withdrawal (incubation of cocaine craving). Here, we studied the role of glial cell line-derived neurotrophic factor (GDNF) in incubation of cocaine craving becau...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.02.009
更新日期：2009-07-15 00:00:00
abstract：BACKGROUND:Schizophrenic patients have high rates of cigarette smoking compared with the general population. We compared sustained-release (SR) bupropion with placebo for smoking cessation in patients with schizophrenic disorders. We also examined how antipsychotic class predicts smoking cessation outcomes with bupropi...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0006-3223(02)01339-2
更新日期：2002-07-01 00:00:00
abstract：:Thyrotropin-releasing hormone (TRH) has been reported to stimulate growth hormone (GH) release in a variety of pathological conditions, including some studies of major depression. Because of the considerable phenomenological and neuroendocrine overlap between major depression and panic disorder, we investigated the ra...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(90)90420-7
更新日期：1990-06-01 00:00:00
abstract：BACKGROUND:Deletions encompassing a four-gene region on chromosome 15 (BP1-BP2 at 15q11.2), seen at a population frequency of 1 in 500, are associated with increased risk for schizophrenia, epilepsy, and other common neurodevelopmental disorders. However, little is known in terms of how these common deletions impact co...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2019.04.008
更新日期：2019-08-15 00:00:00
abstract：BACKGROUND:In addition to cognitive impairment, there are disruptions to mood and emotion processing in attention-deficit/hyperactivity disorder (ADHD) but little is known about their neural basis. We examined ADHD disturbances in mood and emotion recognition and underlying neural systems before and after treatment wit...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.11.022
更新日期：2008-05-15 00:00:00
abstract：BACKGROUND:Anatomic magnetic resonance imaging (MRI) studies of attention-deficit/hyperactivity disorder (ADHD) have been limited by use of callosal rather than sulcal/gyral landmarks in defining cerebral lobes and functionally relevant sublobar regions (e.g., prefrontal cortex). We present an investigation of cerebral...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(02)01412-9
更新日期：2002-10-15 00:00:00
abstract：:Neuroendocrine functions in depressed patients with major affective disorders were serially investigated by the Dexamethasone Suppression Test (DST), the thyrotropin-releasing hormone (TRH) stimulation test, and the plasma TRH-like immunoreactivity (TRH-LI) measurement. Prior to antidepressant therapy, the sensitivity...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(87)90184-3
更新日期：1987-05-01 00:00:00
abstract：:Autonomic characteristics of nonclinical panic and blood phobia were compared using spectral analysis of the electrocardiogram (EKG), as well as more conventional cardiovascular measures. The cardiovascular responses of 11 subjects who reported recent occurrence of frequent severe panic attacks, and 10 subjects who re...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(93)90087-t
更新日期：1993-09-01 00:00:00
abstract：:The concentration of kynurenine, a neuroactive tryptophan metabolite, in blood plasma after pharmacologically induced anxiety was studied. Anxiety was provoked in 15 healthy volunteers by an anxiogenic dose of caffeine. Kynurenine concentration was markedly increased at the peak of anxiety and returned to normal after...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90225-b
更新日期：1991-02-15 00:00:00
abstract：BACKGROUND:Recent findings suggest that both low and very high fasting blood glucose concentrations may be linked with depression, though whether type 2 diabetes is associated with depression may depend on awareness of the diagnosis. We explored the association between fasting glucose and type 2 diabetes (undiagnosed a...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.09.019
更新日期：2010-01-15 00:00:00
abstract：BACKGROUND:Benzodiazepines modulate γ-aminobutyric acid type A (GABA(A)) receptors throughout the brain. However, it is not fully understood which brain regions within anxiety-related brain circuits are really responsible for their anxiolytic effects and how these regions interact. METHODS:We investigated whether the ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.09.004
更新日期：2013-02-15 00:00:00
abstract：BACKGROUND:Schizophrenia (SCZ) is a neurodevelopmental disorder with a progressive, prolonged course. Early prevention for SCZ is promising but overall lacks support from preclinical evidence. Previous studies have tested environmental enrichment (EE) in certain models of SCZ and discovered a broadly beneficial effect ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2020.09.023
更新日期：2021-02-01 00:00:00
abstract：:Methysergide a clinically used blocker of serotonin receptors, was given for 48 hr to 11 normal adults, at a dose of 8 mg per 24 hr. Total REM sleep time was decreased, although total sleep time was unchanged. Stage 4 decreased and stage 3 increased, while total slow wave sleep remained constant. There was a tendency ...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：
更新日期：1975-08-01 00:00:00
abstract：:Women who are of normal weight and have bulimia nervosa exhibit multiple neuroendocrine disturbances. We hypothesized that bingeing and vomiting behavior could be contributory because food consumption in healthy volunteers increases plasma cortisol and prolactin secretion and suppresses growth hormone secretion. Thus,...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90068-w
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (TMS) therapy can modulate pathological neural network functional connectivity in major depressive disorder (MDD). Posttraumatic stress disorder is often comorbid with MDD, and symptoms of both disorders can be alleviated with TMS therapy. This is the first study ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2017.07.021
更新日期：2018-02-01 00:00:00
abstract：:Advances in the understanding of the neurobiology of fear extinction have resulted in the development of d-cycloserine (DCS), a partial glutamatergic N-methyl-D-aspartate agonist, as an augmentation strategy for exposure treatment. We review a decade of research that has focused on the efficacy of DCS for augmenting t...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2015.09.007
更新日期：2016-08-15 00:00:00
abstract：BACKGROUND:K-complexes (KCs) are evoked delta frequency electroencephalogram (EEG) responses during sleep that occur when large numbers of healthy cortical cells burst fire in a synchronized manner. The KC amplitude and incidence are sensitive measures of normal healthy brain aging. Given the known neurodegenerative co...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.10.010
更新日期：2009-07-15 00:00:00
abstract：:Proton spectra in the regions of the right and left basal ganglia were studied in 14 medicated patients with chronic schizophrenia using proton magnetic resonance spectroscopy (1H MRS). Ratios of N-acetyl-aspartate (NAA) to choline-containing compounds (Cho) were significantly reduced in the bilateral basal ganglia re...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(95)00316-9
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:Fear learning in stressful situations is highly adaptive for survival by steering behavior in subsequent situations, but fear learning can become disproportionate in vulnerable individuals. Despite the potential clinical significance, the mechanism by which stress modulates fear learning is poorly understood...
journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.biopsych.2015.02.014
更新日期：2015-12-15 00:00:00
abstract：BACKGROUND:Diabetes, obesity, and overweight are prevalent pregnancy complications that predispose offspring to neurodevelopmental disorders, including autism, attention-deficit/hyperactivity disorder, and schizophrenia. Although male individuals are three to four times more likely than female individuals to develop th...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2016.12.025
更新日期：2017-07-15 00:00:00
abstract：:A cellular model for bipolar illness is presented. It is propounded that alterations in the activity of the membrane sodium- and potassium-activated adenosine triphosphatase pump (Na,K-ATPase) may be responsible for alterations in neuronal excitability and activity. Specifically, a reduction in Na,K-ATPase activity ca...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/0006-3223(94)00201-D
更新日期：1995-02-15 00:00:00
abstract：BACKGROUND:Both corticotropin-releasing factor (CRF) and glucocorticoid receptors (GR) are implicated in the psychotic symptoms of psychiatric disorders. Correspondingly, it is of interest to determine their respective involvement in the sensorimotor gating deficits displayed by transgenic mice overexpressing CRF. Thes...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.06.002
更新日期：2008-02-15 00:00:00
abstract：:A nutritional survey, the Pittsburgh Appetite Test (PAT), was developed to study potential changes in appetite and food preference reported by patients during a depressive episode and during antidepressant treatment. We examined a group of 50 depressed outpatients who were drug-free for 2 weeks prior to treatment with...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(87)90180-6
更新日期：1987-05-01 00:00:00
abstract：:A "risk factor" approach to affective illness is outlined. Characteristics which are correlated with vulnerability to depression (or mania) should be sought and attempts made to either modify them or elucidate a pathophysiologic link between the characteristic and the illness. Genetic factors, biochemical factors, lif...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1983-08-01 00:00:00
abstract：BACKGROUND:Posttraumatic stress disorder (PTSD) is associated with increased risk for age-related diseases and early mortality. An accelerated rate of biological aging could contribute to this increased risk. To investigate, we assessed leukocyte telomere length (LTL), an emerging marker of biological age, in men and w...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2011.01.035
更新日期：2011-09-01 00:00:00
abstract：:The N400 component of event-related potentials (ERPs) was investigated in medicated schizophrenic patients and normal controls in a semantic categorization task. The subjects' task was to indicate whether pairs of words were semantically related or unrelated. The ERPs to the unrelated second words of the pairs contain...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90269-r
更新日期：1991-03-01 00:00:00
abstract：BACKGROUND:Some small controlled studies have found that dawn simulation is effective in treating seasonal affective disorder (SAD). With a larger sample size and a longer duration of treatment, we compared dawn simulation with bright light therapy and a placebo condition in patients with SAD. METHOD:Medication-free p...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0006-3223(01)01200-8
更新日期：2001-08-01 00:00:00
abstract：BACKGROUND:Addiction relies on persistent alterations of neuronal properties, which depends on gene regulation. Activity-regulated cytoskeleton-associated protein (Arc) is an immediate early gene that modulates neuronal plasticity underlying learning and memory. Its role in cocaine-induced neuronal and behavioral adapt...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2016.05.025
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Increased physical activity is a common feature of anorexia nervosa (AN). Although high activity levels are associated with greater risk of developing AN, particularly when combined with dieting, most individuals who diet and exercise maintain a healthy body weight. It is unclear why some individuals develop...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2020.06.030
更新日期：2020-07-16 00:00:00
