A risk factor strategy for investigating affective illness.

abstract：BACKGROUND:22q11.2 deletions and duplications are copy number variations (CNVs) that predispose to developmental neuropsychiatric disorders. Both CNVs are associated with autism spectrum disorder (ASD), while the deletion confers disproportionate risk for schizophrenia. Neurobehavioral profiles associated with these re...

journal_title：Biological psychiatry

authors： Lin A,Vajdi A,Kushan-Wells L,Helleman G,Hansen LP,Jonas RK,Jalbrzikowski M,Kingsbury L,Raznahan A,Bearden CE

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Schizophrenia risk is associated with both genetic and environmental risk factors. Furthermore, cognitive abnormalities are established core characteristics of schizophrenia. We aim to assess whether a classification approach encompassing risk factors, cognition, and their associations can discriminate patie...

journal_title：Biological psychiatry

authors： Antonucci LA,Pergola G,Pigoni A,Dwyer D,Kambeitz-Ilankovic L,Penzel N,Romano R,Gelao B,Torretta S,Rampino A,Trojano M,Caforio G,Falkai P,Blasi G,Koutsouleris N,Bertolino A

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Stimulation of alpha(2)-adrenergic receptors (alpha(2)-ARs) in the prefrontal cortex (PFC) has a beneficial effect on working memory and attentional regulation in monkeys. alpha(2)-adrenergic agonists like clonidine and guanfacine have been used experimentally and clinically for the treatment of attention de...

journal_title：Biological psychiatry

authors： Ma CL,Arnsten AF,Li BM

更新日期：2005-01-15 00:00:00

abstract：BACKGOUND:Alcohol use disorder (AUD) is devastating and poorly treated, and innovative targets are actively sought for prevention and treatment. The orphan G protein-coupled receptor GPR88 is enriched in mesocorticolimbic pathways, and Gpr88 knockout mice show hyperactivity and risk-taking behavior, but a potential rol...

journal_title：Biological psychiatry

authors： Ben Hamida S,Mendonça-Netto S,Arefin TM,Nasseef MT,Boulos LJ,McNicholas M,Ehrlich AT,Clarke E,Moquin L,Gratton A,Darcq E,Harsan LA,Maldonado R,Kieffer BL

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are a well-defined cause of obsessive-compulsive disorder in children. However, they have not been described or fully investigated in adults newly diagnosed with obsessive-compulsive disorder. METHODS:We descri...

journal_title：Biological psychiatry

authors： Bodner SM,Morshed SA,Peterson BS

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Many first-degree relatives of patients with schizophrenia show deficits in clinical, neuropsychological, neurobiological and social domains, in the absence of psychosis. We recently reformulated Meehl's concept of schizotaxia to conceptualize the liability to schizophrenia, and we proposed preliminary crite...

journal_title：Biological psychiatry

authors： Stone WS,Faraone SV,Seidman LJ,Green AI,Wojcik JD,Tsuang MT

更新日期：2001-09-15 00:00:00

abstract：:This paper discusses the current practice of using single word labels for emotional states that ignore the nature of the incentive, cognitive representations, physiologic profile, and especially the developmental stage of the agent. The universal cognitive advances that are derivatives of brain maturation over the fir...

journal_title：Biological psychiatry

authors： Kagan J

更新日期：2001-06-15 00:00:00

abstract：:Drugs with antidepressant properties in patients with severe depression also have various behavioral and neurochemical effects in animals. This has given rise to numerous animal models that have been suggested to be valid for research into the neurobiology of depression and the neurochemical mechanisms of the antidepr...

journal_title：Biological psychiatry

authors： Jesberger JA,Richardson JS

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND:Addiction relies on persistent alterations of neuronal properties, which depends on gene regulation. Activity-regulated cytoskeleton-associated protein (Arc) is an immediate early gene that modulates neuronal plasticity underlying learning and memory. Its role in cocaine-induced neuronal and behavioral adapt...

journal_title：Biological psychiatry

authors： Salery M,Dos Santos M,Saint-Jour E,Moumné L,Pagès C,Kappès V,Parnaudeau S,Caboche J,Vanhoutte P

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Several epidemiologic and clinical factors have been shown to predict long term outcome in major depressive disorder (MDD). The value of biological predictors has not been extensively studied. This study examined whether plasma norepinephrine may be useful in predicting outcome in MDD. METHODS:Forty patient...

journal_title：Biological psychiatry

authors： Johnston TG,Kelly CB,Stevenson MR,Cooper SJ

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Investigators have reported lack of normal asymmetry of lateralization in some schizophrenic patients, as measured postmortem and by preference and/or performance. It has been suggested that this lack of asymmetry is related to early onset of schizophrenia. The present study extends the inquiry by magnetic r...

journal_title：Biological psychiatry

authors： Maher BA,Manschreck TC,Yurgelun-Todd DA,Tsuang MT

更新日期：1998-09-15 00:00:00

abstract：BACKGROUND:Obsessive-compulsive disorder (OCD) is a common and severe psychiatric illness that affects 1-3% of the population and presents a well-established co-morbidity with major depressive disorder (MDD). Twin and family studies have suggested a genetic component in the etiology of OCD, although the mode of inherit...

journal_title：Biological psychiatry

authors： Karayiorgou M,Sobin C,Blundell ML,Galke BL,Malinova L,Goldberg P,Ott J,Gogos JA

更新日期：1999-05-01 00:00:00

abstract：:Altered bioavailability or altered pharmacokinetics of dexamethasone (dex) may contribute to a positive Dexamethasone Suppression Test (DST) in psychiatric patients. We measured plasma dex and plasma cortisol concentrations in 32 patients with primary major depressive disorder (MDD), 14 patients with other psychiatric...

journal_title：Biological psychiatry

authors： Ritchie JC,Belkin BM,Krishnan KR,Nemeroff CB,Carroll BJ

更新日期：1990-01-15 00:00:00

abstract：BACKGROUND:There is evidence that vascular factors contribute substantially to Alzheimer's disease (AD). We have developed assays to reliably detect the circulation and microcirculation regulating factors C-terminal endothelin-1 precursor fragment (CT-proET-1), midregional pro-adrenomedullin (MR-proADM), and midregiona...

journal_title：Biological psychiatry

authors： Buerger K,Ernst A,Ewers M,Uspenskaya O,Omerovic M,Morgenthaler NG,Knauer K,Bergmann A,Hampel H

更新日期：2009-06-01 00:00:00

abstract：:Sixty psychiatrically depressed patients (female = 39, male = 21), classified as psychotic or neurotic, were neuropsychologically assessed on an expanded Halstead-Reitan battery before antidepressant medication. Extant normative data from a large control group (N = 142) were employed for comparative purposes. Statisti...

journal_title：Biological psychiatry

authors： Fromm D,Schopflocher D

更新日期：1984-01-01 00:00:00

abstract：:Schizophrenia is a complex illness with multiple pathophysiologic factors that contribute to its psychopathology. One strategy to identify these factors is to observe them in isolation from each other, by characterizing their expression in the relatives of schizophrenic probands. By Mendel's second law, each genetic f...

journal_title：Biological psychiatry

authors： Waldo MC,Adler LE,Leonard S,Olincy A,Ross RG,Harris JG,Freedman R

更新日期：2000-02-01 00:00:00

abstract：:Psychiatric and neurologic disorders ranging from mental retardation to addiction are accompanied by structural and functional alterations of synaptic connections in the brain. Such alterations include abnormal density and morphology of dendritic spines, synapse loss, and aberrant synaptic signaling and plasticity. Re...

journal_title：Biological psychiatry

authors： Blanpied TA,Ehlers MD

更新日期：2004-06-15 00:00:00

abstract：BACKGROUND:Shared neuropathological characteristics of patients with schizophrenia and their siblings might represent intermediate phenotypes that could be used to investigate genetic susceptibility to the illness. We sought to discover previously unidentified gray matter volume differences in patients with schizophren...

journal_title：Biological psychiatry

authors： Honea RA,Meyer-Lindenberg A,Hobbs KB,Pezawas L,Mattay VS,Egan MF,Verchinski B,Passingham RE,Weinberger DR,Callicott JH

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Impaired response inhibition is a key feature of patients with alcohol dependence. Improving impulse control is a promising target for the treatment of alcohol dependence. The pharmacologic agent modafinil enhances cognitive control functions in both healthy subjects and in patients with various psychiatric ...

journal_title：Biological psychiatry

authors： Schmaal L,Joos L,Koeleman M,Veltman DJ,van den Brink W,Goudriaan AE

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Patients with autism have been often reported to have a smaller corpus callosum (CC) than control subjects. METHODS:We conducted a meta-analysis of the literature, analyzed the CC in 694 subjects of the Autism Brain Imaging Data Exchange project, and performed computer simulations to study the effect of dif...

journal_title：Biological psychiatry

authors： Lefebvre A,Beggiato A,Bourgeron T,Toro R

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:Prior investigations of cross-informant agreement among parents, teachers, and clinicians about externalizing and internalizing problems have not directly addressed agreement about manic symptoms. METHODS:We identified three groups from a large cohort of youths, aged 8-12 years, treated on an inpatient unit...

journal_title：Biological psychiatry

authors： Carlson GA,Youngstrom EA

更新日期：2003-06-01 00:00:00

abstract：:The efficacy of gamma-hydroxybutyrate (GHB) versus placebo for treating narcolepsy was evaluated in 20 patients with narcolepsy, 10 men and 10 women, using a double-blind counterbalanced crossover design. Each patient completed a daily sleep-wake log and questionnaire during a 14-day baseline, a 29-day placebo period,...

journal_title：Biological psychiatry

authors： Scrima L,Hartman PG,Johnson FH Jr,Hiller FC

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Clinically and biologically, autism spectrum disorder (ASD) is heterogeneous. Unusual patterns of visual preference as indexed by eye tracking are hallmarks; however, whether they can be used to define an early biomarker of ASD as a whole or leveraged to define a subtype is unclear. To begin to examine this ...

journal_title：Biological psychiatry

authors： Pierce K,Marinero S,Hazin R,McKenna B,Barnes CC,Malige A

更新日期：2016-04-15 00:00:00

abstract：:Stable schizophrenic and schizoaffective outpatients underwent abrupt withdrawal from a fixed dose of neuroleptic. Prolactin concentrations were determined preceding and following drug withdrawal. Basal prolactin concentrations were significantly lower 3, 4, or 5 days following drug withdrawal than on subsequent days....

journal_title：Biological psychiatry

authors： Kirkpatrick B,Buchanan RW,Maeda K,Carpenter WT Jr,Jauch D,Tamminga CA

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:Pregnancy and the postpartum period are a time of increased risk for women to develop mood disorders. As such, the reproductive safety data on antidepressant use during pregnancy have rapidly expanded over the last decade; however, there is relatively sparse information on maternal/fetal exchange of these me...

journal_title：Biological psychiatry

authors： Hostetter A,Ritchie JC,Stowe ZN

更新日期：2000-11-15 00:00:00

abstract：BACKGROUND:Neurons in the basal ganglia are connected to areas of prefrontal cerebral cortex involved in higher cognitive functions, and these connections occur primarily via the thalamus. In patients with bipolar disorder, regardless of age, neuroimaging studies have consistently reported an increased number of white ...

journal_title：Biological psychiatry

authors： Haznedar MM,Roversi F,Pallanti S,Baldini-Rossi N,Schnur DB,Licalzi EM,Tang C,Hof PR,Hollander E,Buchsbaum MS

更新日期：2005-04-01 00:00:00

abstract：:Borna disease (BD) virus, a still unclassified neurotropic agent, causes either fatal encephalomyelitis or persistent asymptomatic infection in a variety of animal species. We monitored the neuronal functions of intracerebrally infected but healthy rats with three types of learning experiments. Spatial discrimination ...

journal_title：Biological psychiatry

authors： Dittrich W,Bode L,Ludwig H,Kao M,Schneider K

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:A polymorphism in the serotonin transporter (5-HTT) gene modulates the association between adverse early experiences and risk for major depression in adulthood. Although human imaging studies have begun to elucidate the neural circuits involved in the 5-HTT x environment risk factor, a molecular understandin...

journal_title：Biological psychiatry

authors： Carola V,Frazzetto G,Pascucci T,Audero E,Puglisi-Allegra S,Cabib S,Lesch KP,Gross C

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Cognitive dysfunction in schizophrenia may be related to morphologic abnormalities of pyramidal neurons in the dorsal prefrontal cortex (dPFC) and the largest pyramidal neurons in deep layer 3 may be most affected. Immunoreactivity (IR) for the nonphosphorylated epitopes of neurofilament protein (NNFP) ident...

journal_title：Biological psychiatry

authors： Pierri JN,Volk CL,Auh S,Sampson A,Lewis DA

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:Postnatal treatment with the selective serotonin reuptake inhibitor fluoxetine, evokes anxiety and depressive behavior in rodent models in adulthood. We examined the role of serotonin 2A (5-HT2A), serotonin 2C (5-HT2C) and serotonin 1A (5-HT1A) receptors, implicated in the development of anxiety, in the beha...

journal_title：Biological psychiatry

authors： Sarkar A,Chachra P,Vaidya VA

更新日期：2014-12-01 00:00:00