Abstract：
:Schizophrenia is a complex illness with multiple pathophysiologic factors that contribute to its psychopathology. One strategy to identify these factors is to observe them in isolation from each other, by characterizing their expression in the relatives of schizophrenic probands. By Mendel's second law, each genetic factor should be independently distributed in a sibship, so that each can be observed by itself, uncomplicated by the general problems of the illness. Such independently distributed phenotypes are obviously useful for genetic analyses; however, they can also be considered together, to model how various brain dysfunctions may combine to produce psychoses. In addition to a sensory gating deficit linked to the alpha 7-nicotinic acetylcholine receptor locus, schizophrenics and their families have a number of other deficits, including decreased hippocampal volume on magnetic resonance images and increased plasma levels of the dopamine metabolite homovanillic acid. Although such research is far from complete, a heuristic model combining a sensory gating deficit, decreased hippocampal neuron capacity, and increased dopaminergic neurotransmission is consonant with current understanding of the neuropsychology of schizophrenia.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Waldo MC,Adler LE,Leonard S,Olincy A,Ross RG,Harris JG,Freedman Rdoi
10.1016/s0006-3223(99)00272-3subject
Has Abstractpub_date
2000-02-01 00:00:00pages
231-9issue
3eissn
0006-3223issn
1873-2402pii
S0006-3223(99)00272-3journal_volume
47pub_type
杂志文章,评审abstract：:The aim of the present paper was to perform a single trial analysis of event-related potentials in order to elucidate the mechanisms behind a reduced P300 amplitude occurring in unmedicated depressives (n = 11) and schizophrenics (n = 18). For this purpose, tools from linear system theory were applied to single trials...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(95)00652-4
更新日期：1996-11-01 00:00:00
abstract：BACKGROUND:The central nucleus of the amygdala (CeA) mediates stress- and addiction-related processes. Corticotropin-releasing factor (CRF) and nociceptin/orphanin FQ (nociceptin) regulate ethanol intake and anxiety-like behavior. In the rat, CRF and ethanol significantly augment CeA gamma-aminobutyric acid (GABA) rele...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2011.10.032
更新日期：2012-04-15 00:00:00
abstract：:The validity of previously hypothesized predictors of elapse following neuroleptic discontinuation was examined. One hundred sixty-two outpatients, with either Research Diagnostic Criteria schizophrenia or schizoaffective disorder, were discontinued from neuroleptic medication for a 28-day period or until judged to be...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(92)90143-n
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND:Autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD) are associated with complex changes as revealed by functional magnetic resonance imaging. To date, neuroimaging-based models are not able to characterize individuals with sufficient sensitivity and specificity. Further, although evi...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2019.02.019
更新日期：2019-08-15 00:00:00
abstract：BACKGROUND:Abnormalities at several levels of the hypothalamic-pituitary-adrenal axis, which may promote glucocorticoid dependent neurodegeneration, have been reported in patients with Alzheimer's disease. In this study we have explored the possibility that peripheral cortisol metabolism is enhanced and glucocorticoid ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(00)01015-5
更新日期：2001-03-15 00:00:00
abstract：:With a computerized data base, a data retrieval system, and a computer program using the actuarial method of life-table analysis, we compared survival rates in different subgroups of patients with dementia of the Alzheimer type (DAT; n = 199). Men (n = 71) had a shorter duration of survival than women (n = 128), with ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(85)90139-8
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:The etiology of dementia that occurs in patients with schizophrenia is not well understood. Nicotinic acetylcholine receptors have been implicated in cognitive function, and deficits in these receptors have been reported in schizophrenia. METHODS:The present study investigates possible associations of nicot...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(03)00348-2
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (TMS) therapy can modulate pathological neural network functional connectivity in major depressive disorder (MDD). Posttraumatic stress disorder is often comorbid with MDD, and symptoms of both disorders can be alleviated with TMS therapy. This is the first study ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2017.07.021
更新日期：2018-02-01 00:00:00
abstract：:Serum free thyroxine (FT4), total thyroxine (TT4), and Brief Psychiatric Rating Scale (BPRS) measurements were obtained following hospital admission and at 2-week intervals during hospitalization in 80 male psychiatric inpatients with a variety of major psychotic and affective disorders. A strong correlation between t...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(89)90148-0
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:Anxiety disorders are associated with disruptions in both emotional processing and decision making. As a result, anxious individuals often make decisions that favor harm avoidance. However, this bias could be driven by enhanced aversion to uncertainty about the decision outcome (e.g., risk) or aversion to ne...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2016.12.010
更新日期：2017-06-15 00:00:00
abstract：BACKGROUND:Survival and differentiation of neurons and the formation and maintenance of synapses in the cerebral cortex may be affected in schizophrenia. Since neurotrophins play an important role in these events, behavioral effects relevant to schizophrenia were investigated in rats that had compromised neurotrophin f...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2003.12.015
更新日期：2004-04-15 00:00:00
abstract：BACKGROUND:Recent research suggests that immune dysregulation in pregnancy could be a risk factor for anxiety and depression symptoms in offspring. Whereas animal studies have demonstrated the importance of the link between perinatal cytokines and abnormal behaviors in offspring, human epidemiological studies in this a...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2020.10.009
更新日期：2020-10-24 00:00:00
abstract：:Several lines of evidence suggest that dopamine might be involved in anxiety states. In this study, we assessed the growth hormone (GH) response to apomorphine (a dopaminergic agonist) 0.5 mg SC in nine drug-free inpatients meeting Research Diagnostic Criteria (RDC) for panic disorder who were age-matched and gender-m...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(92)90061-4
更新日期：1992-12-01 00:00:00
abstract：BACKGROUND:Schizophrenia patients exhibit impairment in prepulse inhibition (PPI) of the acoustic startle response (ASR), suggesting a sensorimotor gating deficit. The serotonin-2A receptor (5-HT(2A)R) has been implicated in both the pathogenesis of schizophrenia and the PPI deficits of schizophrenia patients. Moreover...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.02.019
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:A novel gastric pentadecapeptide, BPC 157, has been shown to attenuate different lesions (i.e., gastrointestinal tract, liver, pancreas, somatosensory neurons). This suggests an interaction with the dopamine system. When used alone, BPC 157 does not affect gross behavior or induce stereotypy. METHODS:We fir...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(97)00277-1
更新日期：1998-04-01 00:00:00
abstract：BACKGROUND:Although intimate partner violence (IPV) has a great impact on women's health, few studies have assessed the consequences on physiologic responses. METHODS:Women abused by their intimate male partners either physically (n = 70) or psychologically (n = 46) were compared with nonabused control women (n = 46)....
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.06.001
更新日期：2004-08-15 00:00:00
abstract：:This study examined the relationship between borderline and impulsive personality traits on the one hand, and monoamine function on the other in 15 women with bulimia nervosa and 15 women with recurrent suicidal behavior. Platelet serotonin (5-HT) and platelet monoamine oxidase (MAO) activity were used as peripheral m...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(95)00384-3
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:The stomach-derived hormone ghrelin drives higher-order feeding processes related to food reward and food seeking via central nervous system signaling at its receptor (GHSR1A). The specific nuclei mediating these effects are only partially understood. Here, we use a rat model to examine whether ghrelin signa...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.07.002
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Transcranial magnetic stimulation is a novel, experimental procedure in the treatment of psychiatric disorders, most notably mood disorders. Transcranial magnetic stimulation is currently being widely studied in other applications, and its efficacies and potential side effects are being investigated. METHOD...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(00)01086-6
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:The cardiovascular safety of mixed amphetamine salts extended release (MAS XR) was evaluated in 2968 children 6-12 years of age with attention-deficit/hyperactivity disorder (ADHD). METHODS:In this prospective, open-label, noncomparative, community-based study, subjects whose symptoms of ADHD were well cont...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.05.002
更新日期：2007-03-01 00:00:00
abstract：:Interpersonal factors play significant roles in the onset, maintenance, and remission of psychiatric conditions. In the current major diagnostic classification systems for psychiatric disorders, some conditions are defined by the presence of impairments in social interaction or maintaining interpersonal relationships;...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2012.03.033
更新日期：2012-07-15 00:00:00
abstract：BACKGROUND:We previously reported that a single injection of ketamine prior to stress protects against the onset of depressive-like behavior and attenuates learned fear. However, the molecular pathways and brain circuits underlying ketamine-induced stress resilience are still largely unknown. METHODS:Here, we tested w...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2018.02.011
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Interruptions in SSRI treatment have been associated with adverse effects that can resemble depressive illness. We hypothesized that brain regions implicated in depression, with extensive serotonergic innervation, would exhibit changes in activity associated with emergence of symptoms following drug disconti...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0006-3223(02)01441-5
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Animal research shows that early adverse experience results in altered glucocorticoid levels in adulthood, either raised basal levels or accentuated responses to stress. If a similar phenomenon operates in humans, this suggests a biological mechanism whereby early adversity might transmit risk for major depr...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2003.09.013
更新日期：2004-02-15 00:00:00
abstract：BACKGROUND:There is a paucity of neuroimaging data in pediatric-onset obsessive-compulsive disorder (OCD). This multimodal neuroimaging study aimed to identify structural gray (GM) and white matter (WM) microstructure changes in pediatric OCD. METHODS:We obtained structural and diffusion tensor magnetic resonance imag...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2011.06.032
更新日期：2011-12-01 00:00:00
abstract：:Short-term reduction in plasma tryptophan (tryptophan depletion) produces a relapse of depressive symptoms in 60% of previously depressed patients recently recovered with serotonin reuptake inhibitor treatment. Tryptophan depletion does not consistently increase depressive symptoms in unmedicated depressed patients or...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0006-3223(96)00224-7
更新日期：1997-05-01 00:00:00
abstract：BACKGROUND:Thalamic abnormalities resulting in impaired attention and information processing may form a foundation for cognitive and perceptual disturbances in schizophrenia. Measurements of the thalamus in patients with schizophrenia have shown reductions relative to normal comparison subjects. METHODS:In the current...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(97)00459-9
更新日期：1999-05-15 00:00:00
abstract：:Visibility of the nailfold vascular plexus has shown promise as a genetically transmitted marker for liability to schizophrenia. To assess whether this marker is specifically associated with negative or positive symptoms of schizophrenia, we reanalyzed patient data collected 20 years ago, well before interest in the n...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90195-r
更新日期：1991-04-15 00:00:00
abstract：:Mutations in mitochondrial DNA (mtDNA) are implicated in the pathophysiology of affective disorders. To determine whether the 4977-base-pair deletion in mtDNA is more frequent in affective disorders, we quantitated the concentration of this deletion in leukocyte mtDNA in 34 probands with affective disorders (20 bipola...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/S0006-3223(96)00377-0
更新日期：1997-09-01 00:00:00
abstract：:An experimental paradigm employed by several workers in the field of schizophrenic eye movements has involved finding sequences of stimuli that induce saccadic smooth pursuit in the eye movements of normal individuals. It is hoped that the identification of such stimuli will lead to clues concerning the etiology or na...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(90)90457-d
更新日期：1990-10-15 00:00:00
