Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms.

abstract：BACKGROUND:Mismatch negativity (MMN) is a negative-going event-related potential (ERP) component that occurs in response to intermittent changes in constant auditory backgrounds. A consistent finding across a large number of studies has been impaired MMN generation in schizophrenia, which has been interpreted as eviden...

journal_title：Biological psychiatry

authors： Magno E,Yeap S,Thakore JH,Garavan H,De Sanctis P,Foxe JJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:In an earlier analysis of 73 subjects from this study, the reduced activity catechol O-methyltransferase variant was shown to be associated with obsessive-compulsive disorder in men only. We hypothesized that the 5-HT2A promoter polymorphism, -1438G>A, previously associated with anorexia nervosa, would be mo...

journal_title：Biological psychiatry

authors： Enoch MA,Greenberg BD,Murphy DL,Goldman D

更新日期：2001-02-15 00:00:00

abstract：BACKGROUND:Numerous studies have implicated neurogenesis in the hippocampus in animal models of depression, especially those related to controllability and learned helplessness. Here, we tested the hypothesis that uncontrollable but not controllable stress would reduce cell proliferation in the hippocampus of male and ...

journal_title：Biological psychiatry

authors： Shors TJ,Mathew J,Sisti HM,Edgecomb C,Beckoff S,Dalla C

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are potent regulators of gene expression with proposed roles in brain development and function. We hypothesized that miRNA expression profiles are altered in individuals with severe psychiatric disorders. METHODS:With real-time quantitative polymerase chain reaction, we compared the expre...

journal_title：Biological psychiatry

authors： Moreau MP,Bruse SE,David-Rus R,Buyske S,Brzustowicz LM

更新日期：2011-01-15 00:00:00

abstract：BACKGROUND:A number of investigators have reported finding elevated basal and stimulated intracellular calcium levels in the platelets or lymphocytes of bipolar disorder patients. METHODS:Intracellular calcium was measured by a micro fura-2 fluorometric method in the platelets and lymphocytes of 30 affective disorder ...

journal_title：Biological psychiatry

authors： Hough C,Lu SJ,Davis CL,Chuang DM,Post RM

更新日期：1999-07-15 00:00:00

abstract：:A broad definition of sensory gating refers to the ability of the brain to modulate its sensitivity to incoming sensory stimuli. This definition allows the concept of gating to include both the capacities to minimize or stop responding to incoming irrelevant stimuli (gating out) and to respond when a novel stimulus is...

journal_title：Biological psychiatry

authors： Boutros NN,Belger A

更新日期：1999-04-01 00:00:00

abstract：:The volume of the entorhinal region is significantly reduced in postmortem brains of schizophrenics compared with controls (p less than 0.017). In addition, a significant reduction of neurons (p less than 0.017), but no significant increase in absolute glial cell numbers, is found. These results are consistent with th...

journal_title：Biological psychiatry

authors： Falkai P,Bogerts B,Rozumek M

更新日期：1988-09-01 00:00:00

abstract：:This study evaluated the effect of an acute reduction in catecholamine synthesis produced by alpha-methyl-para-tyrosine (AMPT), a tyrosine hydroxylase inhibitor, on cocaine-induced euphoria. In a blinded, placebo-controlled study, AMPT (1 g p.o. T.I.D.) was given to 10 non-treatment-seeking cocaine abusers prior to in...

journal_title：Biological psychiatry

authors： Stine SM,Krystal JH,Petrakis IL,Jatlow PI,Heninger GR,Kosten TR,Charney DS

更新日期：1997-08-01 00:00:00

abstract：:Several studies have indicated that patients with panic attacks have a higher rate of suicide attempts as well as deaths from suicide. Additionally, several investigators have presented case reports of individuals manifesting suicidal and violent behaviors directly and temporally associated with panic attacks. We repo...

journal_title：Biological psychiatry

authors： Korn ML,Kotler M,Molcho A,Botsis AJ,Grosz D,Chen C,Plutchik R,Brown SL,van Praag HM

更新日期：1992-03-15 00:00:00

abstract：:Chromatin structure and nucleohistone pattern were investigated histochemically in the neutrophils of 11 schizophrenics and 16 healthy controls. Compared to controls, all schizophrenic parents prior to medication showed a distinctly different histochemical pattern consisting of increased concentration and abnormal dis...

journal_title：Biological psychiatry

authors： Stefanis CN,Issidorides MR

更新日期：1976-02-01 00:00:00

abstract：:The psychiatric histories of relatives of 17 boys admitted to an inpatient unit with "unsocialized aggressive" behavior and of 19 boys admitted with other problems were investigated by means of structured interviews. The interviews were rated blind and diagnoses made on the respondents and relatives described in the f...

journal_title：Biological psychiatry

authors： Stewart MA,Leone L

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND:Amphetamine administration induces stimulation-independent dopamine release in the nucleus accumbens (NAcc) through reverse dopamine transport, a critical neurochemical event involved in its psychostimulant action, and furthermore decreases stimulation-dependent vesicular dopamine release. These effects may ...

journal_title：Biological psychiatry

authors： David HN,Ansseau M,Lemaire M,Abraini JH

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Nicotine is highly addictive when it is inhaled from tobacco smoke, whereas nicotine replacement products, which usually deliver nicotine orally or transdermally, rarely lead to addiction. It has been proposed that this is due in part to differences in the rate of nicotine delivery to the brain under the two...

journal_title：Biological psychiatry

authors： Samaha AN,Yau WY,Yang P,Robinson TE

更新日期：2005-02-15 00:00:00

abstract：:Animal models of mental illness provide a foundation for evaluating hypotheses for the mechanistic causes of mental illness. Neurophysiological investigations of neural network activity in rodent models of mental dysfunction are reviewed from the conceptual framework of the discoordination hypothesis, which asserts th...

journal_title：Biological psychiatry

authors： Fenton AA

更新日期：2015-06-15 00:00:00

abstract：BACKGROUND:Venlafaxine blocks both serotonin and norepinephrine transporters (SERT and NET), with higher affinity for SERT. Serotonergic effects occur with lower doses, whereas both serotonergic and noradrenergic effects occur with higher doses of venlafaxine. Chronic treatment of rats with selective serotonin reuptake...

journal_title：Biological psychiatry

authors： Gould GG,Altamirano AV,Javors MA,Frazer A

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Pathogenic mutations in the X-linked Neuroligin 4 gene (NLGN4X) in autism spectrum disorders (ASDs) and/or mental retardation (MR) are rare. However, nothing is known regarding a possible altered expression level of NLGN4X that would be caused by mutations in regulatory sequences. We investigated this issue ...

journal_title：Biological psychiatry

authors： Daoud H,Bonnet-Brilhault F,Védrine S,Demattéi MV,Vourc'h P,Bayou N,Andres CR,Barthélémy C,Laumonnier F,Briault S

更新日期：2009-11-15 00:00:00

abstract：BACKGOUND:Alcohol use disorder (AUD) is devastating and poorly treated, and innovative targets are actively sought for prevention and treatment. The orphan G protein-coupled receptor GPR88 is enriched in mesocorticolimbic pathways, and Gpr88 knockout mice show hyperactivity and risk-taking behavior, but a potential rol...

journal_title：Biological psychiatry

authors： Ben Hamida S,Mendonça-Netto S,Arefin TM,Nasseef MT,Boulos LJ,McNicholas M,Ehrlich AT,Clarke E,Moquin L,Gratton A,Darcq E,Harsan LA,Maldonado R,Kieffer BL

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Using diffusion tensor imaging (DTI), we previously reported abnormalities in two critical white matter tracts in schizophrenia, the uncinate fasciculus (UF) and the cingulum bundle (CB), both related to fronto-temporal connectivity. Here, we investigate these two bundles in unmedicated subjects with schizot...

journal_title：Biological psychiatry

authors： Nakamura M,McCarley RW,Kubicki M,Dickey CC,Niznikiewicz MA,Voglmaier MM,Seidman LJ,Maier SE,Westin CF,Kikinis R,Shenton ME

更新日期：2005-09-15 00:00:00

abstract：:Mismatch negativity (MMN), in the deviant-minus-standard event-related potential (ERP) difference-waveform, may represent a working memory trace of the tone difference. Most but not all studies find MMN reduced in schizophrenic patients. This report investigates if differences may be attributable to experimental condi...

journal_title：Biological psychiatry

authors： Oades RD,Dittmann-Balcar A,Zerbin D,Grzella I

更新日期：1997-06-15 00:00:00

abstract：:Several lines of evidence suggest that the anticonvulsant drug valproate may have antipanic properties: (1) It enhances gamma-aminobutyric acid activity in the brain; (2) it has anxiolytic effects in animal models of anxiety; and (3) it has been reported to be effective in panic disorder in several preliminary studies...

journal_title：Biological psychiatry

authors： Keck PE Jr,Taylor VE,Tugrul KC,McElroy SL,Bennett JA

更新日期：1993-04-01 00:00:00

abstract：:We examined the association between post-dexamethasone suppression test (DST) serum cortisol and body weight, self-report of weight loss during the episode, and measured weight loss during the first week of admission in a series of 245 depressed inpatients. Data on measured weight loss between two successive admission...

journal_title：Biological psychiatry

authors： Pfohl B,Coryell W,Stangl D,Zimmerman M

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:Acute ketamine has been shown to model features of schizophrenia such as psychotic symptoms, cognitive deficits and smooth pursuit eye movement dysfunction. There have been suggestions that chronic ketamine may also produce an analogue of the disorder. In this study, we investigated the effect of persistent ...

journal_title：Biological psychiatry

authors： Morgan CJ,Huddy V,Lipton M,Curran HV,Joyce EM

更新日期：2009-06-15 00:00:00

abstract：BACKGROUND:In this study we extended previous work by examining whether disturbances in the circadian rhythms of cortisol during the menstrual cycle distinguish patients with premenstrual dysphoric disorder (PMDD) from normal control (NC) subjects. In addition, we tested the differential response to the effects of earl...

journal_title：Biological psychiatry

authors： Parry BL,Javeed S,Laughlin GA,Hauger R,Clopton P

更新日期：2000-11-01 00:00:00

abstract：:Auditory event-related potentials (ERPs) associated with selective attention were recorded in 21 children at high-risk for schizophrenia and in 21 matched controls. The subjects performed a selective listening task. For behavioral evaluation, target counts on the selective listening task and on cognitive performance w...

journal_title：Biological psychiatry

authors： Schreiber H,Stolz-Born G,Kornhuber HH,Born J

更新日期：1992-10-15 00:00:00

abstract：:Pre-treatment and posttreatment dexamethasone suppression test (DST) results in physically healthy elderly major depressives without dementia demonstrated an association between treatment and DST normalization. Sixty percent of subjects were nonsuppressors at baseline compared to 17% after intensive treatment. DST res...

journal_title：Biological psychiatry

authors： Meyers BS,Alpert S,Gabriele M,Kakuma T,Kalayam B,Alexopoulos GS

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Whether paternal age effect on schizophrenia is a causation or just an association due to confounding by selection into late parenthood is still debated. We investigated the association between paternal age and early onset of schizophrenia in offspring, controlling for both paternal and maternal predispositi...

journal_title：Biological psychiatry

authors： Wang SH,Hsiao PC,Yeh LL,Liu CM,Liu CC,Hwang TJ,Hsieh MH,Chien YL,Lin YT,Huang YT,Chen CY,Chandler SD,Faraone SV,Neale B,Glatt SJ,Tsuang MT,Hwu HG,Chen WJ

更新日期：2019-07-01 00:00:00

abstract：:The relationship between plasma kynurenine (KYN) concentration and anxiety and depression in psychiatric patients was examined. KYN has been reported as a probable endogenous anxiogen in animal models of anxiety. Thirty patients with affective states were studied. The Hamilton Anxiety Scale (HAM-A), Hamilton Depressio...

journal_title：Biological psychiatry

authors： Orlikov AB,Prakhye IB,Ryzov IV

更新日期：1994-07-15 00:00:00

abstract：:Parental stress exposures are implicated in the risk for offspring neurodevelopmental and neuropsychiatric disorders, prompting critical examination of preconception and prenatal periods as vulnerable to environmental insults such as stress. Evidence from human studies and animal models demonstrates the influence that...

journal_title：Biological psychiatry

authors： Chan JC,Nugent BM,Bale TL

更新日期：2018-05-15 00:00:00

abstract：BACKGROUND:Recent findings suggest that both low and very high fasting blood glucose concentrations may be linked with depression, though whether type 2 diabetes is associated with depression may depend on awareness of the diagnosis. We explored the association between fasting glucose and type 2 diabetes (undiagnosed a...

journal_title：Biological psychiatry

authors： Gale CR,Kivimaki M,Lawlor DA,Carroll D,Phillips AC,Batty GD

更新日期：2010-01-15 00:00:00

abstract：BACKGROUND:Several lines of evidence suggest the presence of abnormalities in the endocannabinoid (eCB) system in schizophrenia (SCZ). However, there are limited in vivo measures of the eCB system in SCZ. METHODS:Twenty five male SCZ subjects (SCZs) (18 antipsychotic treated and 7 antipsychotic free) were compared wit...

journal_title：Biological psychiatry

authors： Ranganathan M,Cortes-Briones J,Radhakrishnan R,Thurnauer H,Planeta B,Skosnik P,Gao H,Labaree D,Neumeister A,Pittman B,Surti T,Huang Y,Carson RE,D'Souza DC

更新日期：2016-06-15 00:00:00