Exposure to postnatal depression predicts elevated cortisol in adolescent offspring.

Abstract:

BACKGROUND:Animal research shows that early adverse experience results in altered glucocorticoid levels in adulthood, either raised basal levels or accentuated responses to stress. If a similar phenomenon operates in humans, this suggests a biological mechanism whereby early adversity might transmit risk for major depression, glucocorticoid elevations being associated with the development of this disorder. METHODS:We measured salivary cortisol at 8:00 am and 8:00 pm over 10 days in 13-year-old adolescents who had (n = 48) or had not (n = 39) been exposed to postnatal maternal depression. RESULTS:Maternal postnatal depression was associated with higher, more variable morning cortisol in offspring, a pattern previously found to predict major depression. CONCLUSIONS:Early adverse experiences might alter later steroid levels in humans. Because maternal depression confers added risk for depression to children, these alterations might provide a link between early events and later psychopathology.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Halligan SL,Herbert J,Goodyer IM,Murray L

doi

10.1016/j.biopsych.2003.09.013

subject

Has Abstract

pub_date

2004-02-15 00:00:00

pages

376-81

issue

4

eissn

0006-3223

issn

1873-2402

pii

S0006322303010448

journal_volume

55

pub_type

杂志文章
  • Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression.

    abstract:BACKGROUND:Endocytic dysfunction and neurotrophin signaling deficits may underlie the selective vulnerability of hippocampal neurons during the progression of Alzheimer's disease (AD), although there is little direct in vivo and biochemical evidence to support this hypothesis. METHODS:Microarray analysis of hippocampa...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2010.05.030

    authors: Ginsberg SD,Alldred MJ,Counts SE,Cataldo AM,Neve RL,Jiang Y,Wuu J,Chao MV,Mufson EJ,Nixon RA,Che S

    更新日期:2010-11-15 00:00:00

  • Circadian patterns of cortisol, prolactin, and growth hormonal secretion during bingeing and vomiting in normal weight bulimic patients.

    abstract::Women who are of normal weight and have bulimia nervosa exhibit multiple neuroendocrine disturbances. We hypothesized that bingeing and vomiting behavior could be contributory because food consumption in healthy volunteers increases plasma cortisol and prolactin secretion and suppresses growth hormone secretion. Thus,...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(91)90068-w

    authors: Weltzin TE,McConaha C,McKee M,Hsu LK,Perel J,Kaye WH

    更新日期:1991-07-01 00:00:00

  • Dysfunctional glutamatergic and γ-aminobutyric acidergic activities in prefrontal cortex of mice in social defeat model of depression.

    abstract:BACKGROUND:Depression is a complex neuropsychiatric syndrome that is often very severe and life threatening. In spite of the remarkable progress in understanding the neural biology, the etiopathophysiology of depression is still elusive. In this study, we have investigated molecular mechanisms in the prefrontal cortex ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2013.09.024

    authors: Veeraiah P,Noronha JM,Maitra S,Bagga P,Khandelwal N,Chakravarty S,Kumar A,Patel AB

    更新日期:2014-08-01 00:00:00

  • Using Clinical Characteristics to Identify Which Patients With Major Depressive Disorder Have a Higher Genetic Load for Three Psychiatric Disorders.

    abstract:BACKGROUND:Limited successes of gene finding for major depressive disorder (MDD) may be partly due to phenotypic heterogeneity. We tested whether the genetic load for MDD, bipolar disorder, and schizophrenia (SCZ) is increased in phenotypically more homogenous MDD patients identified by specific clinical characteristic...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2016.05.024

    authors: Verduijn J,Milaneschi Y,Peyrot WJ,Hottenga JJ,Abdellaoui A,de Geus EJC,Smit JH,Breen G,Lewis CM,Boomsma DI,Beekman ATF,Penninx BWJH

    更新日期:2017-02-15 00:00:00

  • Learned helplessness increases 5-hydroxytryptamine1B receptor mRNA levels in the rat dorsal raphe nucleus.

    abstract::Learned helplessness is a behavioral condition induced by exposure to inescapable stress that models aspects of stress-related disorders including depression and posttraumatic stress disorder, and has been associated with diminished serotonin release in the rat frontal cortex. Our hypothesis was that presynaptic 5-hyd...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/S0006-3223(96)00114-X

    authors: Neumaier JF,Petty F,Kramer GL,Szot P,Hamblin MW

    更新日期:1997-03-15 00:00:00

  • Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in Long-Term Social and Object Recognition and Sensorimotor Development.

    abstract:BACKGROUND:Quantitative genetic analysis of basic mouse behaviors is a powerful tool to identify novel genetic phenotypes contributing to neurobehavioral disorders. Here, we analyzed genetic contributions to single-trial, long-term social and nonsocial recognition and subsequently studied the functional impact of an id...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2015.01.017

    authors: Bruining H,Matsui A,Oguro-Ando A,Kahn RS,Van't Spijker HM,Akkermans G,Stiedl O,van Engeland H,Koopmans B,van Lith HA,Oppelaar H,Tieland L,Nonkes LJ,Yagi T,Kaneko R,Burbach JP,Yamamoto N,Kas MJ

    更新日期:2015-10-01 00:00:00

  • Social isolation in animal models of relevance to neuropsychiatric disorders.

    abstract::Animal models of social isolation have been suggested to be relevant to several neuropsychiatric disorders; however, social isolation is usually not purely an alteration of social environment, as it often involves such factors as decreased complexity of the environment, loss of tactile stimulation, and increased metab...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(95)00546-3

    authors: Kim JW,Kirkpatrick B

    更新日期:1996-11-01 00:00:00

  • A study of relationships of serum glucose, insulin, free fatty acids, and free and total tryptophan to mental illness.

    abstract::To explore possible disturbances of cerebral monoamines linked to glucose metabolism, 18 schizophrenics, 21 neurotics, and 21 controls were given a 5-hr glucose tolerance test, and the effect of the glucose load on total and free tryptophan, insulin, and free fatty acids in serum was studied in medication-free patient...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:

    authors: Yaryura-Tobias JA,Chang A,Neziroglu F

    更新日期:1978-04-01 00:00:00

  • Regional cerebral glucose metabolic abnormalities in bipolar II depression.

    abstract:BACKGROUND:Functional neuroimaging studies of bipolar disorder (BD) performed in conjunction with antidepressant treatment trials generally require that patients remain on mood stabilizers to reduce the risk of inducing mania; yet, it is unknown whether the metabolic abnormalities evident in unmedicated BD depressives ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2006.06.009

    authors: Mah L,Zarate CA Jr,Singh J,Duan YF,Luckenbaugh DA,Manji HK,Drevets WC

    更新日期:2007-03-15 00:00:00

  • Convergence of Sex Differences and the Neuroimmune System in Autism Spectrum Disorder.

    abstract::The male bias in autism spectrum disorder incidence is among the most extreme of all neuropsychiatric disorders, yet the origins of the sex difference remain obscure. Developmentally, males are exposed to high levels of testosterone and its byproduct, estradiol. Together these steroids modify the course of brain devel...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.biopsych.2016.10.004

    authors: McCarthy MM,Wright CL

    更新日期:2017-03-01 00:00:00

  • Affected Anatomical Rich Club and Structural-Functional Coupling in Young Offspring of Schizophrenia and Bipolar Disorder Patients.

    abstract:BACKGROUND:Emerging evidence suggests disruptions in the wiring organization of the brain's network in schizophrenia (SZ) and bipolar disorder (BD). As the importance of genetic predisposition has been firmly established in these illnesses, children (offspring) of patients constitute an at-risk population. This study e...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2017.06.013

    authors: Collin G,Scholtens LH,Kahn RS,Hillegers MHJ,van den Heuvel MP

    更新日期:2017-11-15 00:00:00

  • Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression.

    abstract:BACKGROUND:Maintenance treatment to prevent recurrences is recommended for chronic forms of major depressive disorder (MDD), but few studies have examined maintenance efficacy of antidepressants with chronic MDD. This randomized, placebo-controlled study of the efficacy and safety of nefazodone in preventing recurrence...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0006-3223(02)01971-6

    authors: Gelenberg AJ,Trivedi MH,Rush AJ,Thase ME,Howland R,Klein DN,Kornstein SG,Dunner DL,Markowitz JC,Hirschfeld RM,Keitner GI,Zajecka J,Kocsis JH,Russell JM,Miller I,Manber R,Arnow B,Rothbaum B,Munsaka M,Banks P,Borian

    更新日期:2003-10-15 00:00:00

  • Cortisol regulation in posttraumatic stress disorder and major depression: a chronobiological analysis.

    abstract::The aim of the present study was to evaluate the pattern of basal cortisol release in PTSD and major depression using a chronobiological analysis. Plasma for cortisol determination was obtained from 15 combat veterans with PTSD, 14 subjects with major depression, and 15 normal men every 30 min during a 24-hour period ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(95)00451-3

    authors: Yehuda R,Teicher MH,Trestman RL,Levengood RA,Siever LJ

    更新日期:1996-07-15 00:00:00

  • Subtle fluctuations in psychotic phenomena as functional states of abnormal dopamine reactivity in individuals at risk.

    abstract:BACKGROUND:Subjects at increased risk for psychosis experience continuous variation in the intensity of subtle psychotic experiences in response to minor stressors. It was investigated whether this psychotic reactivity in individuals at risk for psychosis is the exophenotypic expression of an underlying endophenotype c...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.biopsych.2005.02.012

    authors: Myin-Germeys I,Marcelis M,Krabbendam L,Delespaul P,van Os J

    更新日期:2005-07-15 00:00:00

  • Learning From Animal Models of Obsessive-Compulsive Disorder.

    abstract::Obsessive-compulsive disorder (OCD) affects 2%-3% of the population worldwide and can cause significant distress and disability. Substantial challenges remain in the field of OCD research and therapeutics. Approved interventions alleviate symptoms only partially, with 30%-40% of patients being resistant to treatment. ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.biopsych.2015.04.020

    authors: Monteiro P,Feng G

    更新日期:2016-01-01 00:00:00

  • Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia.

    abstract:BACKGROUND:Growing evidence supports a pivotal role for the amygdala in the pathogenesis of bipolar disorder (BD) and schizophrenia (SZ). However, the occurrence of morphologic changes in the amygdala is currently controversial. METHODS:Total number and numeric density of neurons, neuronal somata size, and volume of t...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2007.04.023

    authors: Berretta S,Pantazopoulos H,Lange N

    更新日期:2007-10-15 00:00:00

  • Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses.

    abstract:BACKGROUND:Neurons in the basal ganglia are connected to areas of prefrontal cerebral cortex involved in higher cognitive functions, and these connections occur primarily via the thalamus. In patients with bipolar disorder, regardless of age, neuroimaging studies have consistently reported an increased number of white ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2005.01.002

    authors: Haznedar MM,Roversi F,Pallanti S,Baldini-Rossi N,Schnur DB,Licalzi EM,Tang C,Hof PR,Hollander E,Buchsbaum MS

    更新日期:2005-04-01 00:00:00

  • Ziskind-Somerfeld Research Award 1996. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder.

    abstract::Prior magnetic resonance imaging (MRI) studies report both medial and lateral cortical temporal changes and disturbed temporal lobe asymmetries in schizophrenic patients compared with healthy controls. The specificity of temporal lobe (TL) changes in schizophrenia is unknown. We determined the occurrence and specifici...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(96)00373-3

    authors: Pearlson GD,Barta PE,Powers RE,Menon RR,Richards SS,Aylward EH,Federman EB,Chase GA,Petty RG,Tien AY

    更新日期:1997-01-01 00:00:00

  • Plasmatic vasopressin neurophysin in depression: basic levels and relations with HPA axis.

    abstract::A decreased secretion of arginine vasopressin (AVP) has been implicated in depression. In order to further investigate this hypothesis, we studied the plasma level of the specific peptidergic carrier of AVP, vasopressin neurophysin (hNpI), in 26 depressed inpatients and 16 matched normal controls. On the other hand, A...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(90)90423-y

    authors: Laruelle M,Seghers A,Goffinet S,Bouchez S,Legros JJ

    更新日期:1990-06-01 00:00:00

  • Functional imaging as a predictor of schizophrenia.

    abstract:BACKGROUND:Prospective studies of young individuals at high risk of schizophrenia allow the investigation of whether neural abnormalities predate development of illness and, if present, have the potential to identify those who may become ill. METHODS:We studied young individuals with at least two relatives with the di...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2005.11.013

    authors: Whalley HC,Simonotto E,Moorhead W,McIntosh A,Marshall I,Ebmeier KP,Owens DG,Goddard NH,Johnstone EC,Lawrie SM

    更新日期:2006-09-01 00:00:00

  • Regional prefrontal gray and white matter abnormalities in bipolar disorder.

    abstract:BACKGROUND:Previous magnetic resonance imaging (MRI) studies indicate that compared with healthy volunteers, patients with bipolar disorder have structural and functional abnormalities in the prefrontal cortex. The aim of this study was to investigate differences in prefrontal subregions between bipolar patients and he...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(02)01350-1

    authors: López-Larson MP,DelBello MP,Zimmerman ME,Schwiers ML,Strakowski SM

    更新日期:2002-07-15 00:00:00

  • No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study.

    abstract:BACKGROUND:Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported, necessitating further investigation. METHODS:We organized a multicent...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.biopsych.2004.06.017

    authors: Kunugi H,Iijima Y,Tatsumi M,Yoshida M,Hashimoto R,Kato T,Sakamoto K,Fukunaga T,Inada T,Suzuki T,Iwata N,Ozaki N,Yamada K,Yoshikawa T

    更新日期:2004-09-01 00:00:00

  • Long-term test-retest reliability of event-related potentials in normals and alcoholics.

    abstract::The long-term test-retest reliability of event-related potentials (ERP) measures was examined in a group of 44 controls and 71 chronic alcoholics, retested after an average of 14 months. Correlational analyses revealed moderately significant test-retest correlations for visual and auditory target N1, N2, and P3 amplit...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(92)90060-d

    authors: Sinha R,Bernardy N,Parsons OA

    更新日期:1992-12-01 00:00:00

  • Microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric and neurological disease.

    abstract::Psychiatric and neurologic disorders ranging from mental retardation to addiction are accompanied by structural and functional alterations of synaptic connections in the brain. Such alterations include abnormal density and morphology of dendritic spines, synapse loss, and aberrant synaptic signaling and plasticity. Re...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.biopsych.2003.10.006

    authors: Blanpied TA,Ehlers MD

    更新日期:2004-06-15 00:00:00

  • Joint influence of alcohol, tobacco, and coffee on biological markers of heavy drinking in alcoholics.

    abstract:BACKGROUND:Recent reports suggest that gamma-glutamyl transferase (GGT) decreases with coffee intake. The aim of this study was to examine the joint influence of alcohol, tobacco, cotinine, coffee, and caffeine on biological markers of heavy drinking in an alcoholic population. METHODS:Subjects were 160 alcohol-depend...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0006-3223(97)00438-1

    authors: Aubin HJ,Laureaux C,Zerah F,Tilikete S,Vernier F,Vallat B,Barrucand D

    更新日期:1998-10-01 00:00:00

  • Adolescent fears as predictors of depression.

    abstract:BACKGROUND:Recent studies raise questions on the relationship between adolescent fears and risk for major depression. METHODS:An epidemiologic sample of 776 young people received psychiatric assessments in 1983, 1985-1986, and 1992. Prospective associations were examined between fears in adolescence and future episode...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(01)01238-0

    authors: Pine DS,Cohen P,Brook J

    更新日期:2001-11-01 00:00:00

  • Sleep electroencephalographic response to muscarinic and serotonin1A receptor probes in patients with major depression and in normal controls.

    abstract:BACKGROUND:To test the hypothesis that depression is associated with an increased ratio of cholinergic to serotonergic neurotransmission, we compared the effects of pilocarpine, a muscarinic agonist, and ipsapirone, a serotonin (5-HT)1A agonist, on electroencephalographic (EEG) sleep in depressed and healthy subjects. ...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0006-3223(97)00551-9

    authors: Seifritz E,Gillin JC,Rapaport MH,Kelsoe JR,Bhatti T,Stahl SM

    更新日期:1998-07-01 00:00:00

  • "Normal" personality correlates of sensorimotor, cognitive, and visuospatial gating.

    abstract::Specific psychiatric disorders are characterized by impaired selective inhibition or "gating" of responses to sensory or cognitive information. Less is known about gating differences among normal individuals. We tested carefully screened controls in measures of central inhibition: prepulse inhibition (PPI) of startle,...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(94)00138-S

    authors: Swerdlow NR,Filion D,Geyer MA,Braff DL

    更新日期:1995-03-01 00:00:00

  • Neural Mechanisms of Early-Life Social Stress as a Developmental Risk Factor for Severe Psychiatric Disorders.

    abstract:BACKGROUND:To explore the domain-general risk factor of early-life social stress in mental illness, rearing rodents in persistent postweaning social isolation has been established as a widely used animal model with translational relevance for neurodevelopmental psychiatric disorders such as schizophrenia. Although chan...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2017.12.010

    authors: Reinwald JR,Becker R,Mallien AS,Falfan-Melgoza C,Sack M,Clemm von Hohenberg C,Braun U,Cosa Linan A,Gass N,Vasilescu AN,Tollens F,Lebhardt P,Pfeiffer N,Inta D,Meyer-Lindenberg A,Gass P,Sartorius A,Weber-Fahr W

    更新日期:2018-07-15 00:00:00

  • Relative risk for cognitive impairments in siblings of patients with schizophrenia.

    abstract:BACKGROUND:Patients with schizophrenia have impairments in several domains of cognition, including working memory/executive function, verbal memory, language, oculomotor scanning/psychomotor speed, and general intelligence. Impairments have also been found in unaffected siblings, suggesting they could be heritable. To ...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0006-3223(01)01133-7

    authors: Egan MF,Goldberg TE,Gscheidle T,Weirich M,Rawlings R,Hyde TM,Bigelow L,Weinberger DR

    更新日期:2001-07-15 00:00:00