Abstract：
BACKGROUND:Previous magnetic resonance imaging (MRI) studies indicate that compared with healthy volunteers, patients with bipolar disorder have structural and functional abnormalities in the prefrontal cortex. The aim of this study was to investigate differences in prefrontal subregions between bipolar patients and healthy subjects. METHODS:Bipolar patients hospitalized for a manic episode (n = 17), and demographically matched healthy volunteers (n = 12) were recruited. Contiguous 1-mm coronal T1-weighted MRI slices were obtained using a Picker 1.5 Tesla scanner. The gray and white matter volumes of five prefrontal subregions of interest were measured: superior, middle, inferior, cingulate, and orbital. RESULTS:Bipolar patients had smaller left prefrontal gray matter volumes, specifically in the middle and superior subregions and smaller right prefrontal gray matter volumes, specifically in the inferior and middle subregions. White matter differences were not observed in any of the prefrontal subregions. CONCLUSIONS:The results suggest that bipolar patients have subregion-specific gray matter volume reductions in the prefrontal cortex as compared to healthy subjects. Further investigations into the role of specific prefrontal subregions in bipolar disorder are warranted.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
López-Larson MP,DelBello MP,Zimmerman ME,Schwiers ML,Strakowski SMdoi
10.1016/s0006-3223(02)01350-1subject
Has Abstractpub_date
2002-07-15 00:00:00pages
93-100issue
2eissn
0006-3223issn
1873-2402pii
S0006322302013501journal_volume
52pub_type
杂志文章abstract：:This paper is not a comprehensive review of the literature. Rather, it is a viewpoint based upon advances in other fields of medicine and genetics that may provide a model for guiding research in psychiatry. The paper discusses the major limitations of the medicines currently used to treat schizophrenia and bipolar il...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 共识发展会议,杂志文章
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更新日期：2008-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1975-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：1993-01-15 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1992-07-15 00:00:00
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更新日期：2015-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.11.009
更新日期：2008-04-15 00:00:00
