Abstract:
BACKGROUND:A deficit in sustained attention might serve as an endophenotype for schizophrenia and therefore be a useful tool in understanding the genetic underpinnings of the disorder. We sought to detail functional brain abnormalities associated with sustained attention (i.e., vigilance) in individuals with genetic liability for schizophrenia. METHODS:We gathered electrophysiological data from 23 schizophrenia patients, 28 first-degree biological relatives of schizophrenia patients, and 23 nonpsychiatric control subjects while they performed a degraded-stimulus continuous performance task. Inclusion of sensory control trials allowed separation of target detection and vigilance effects on brain potentials. RESULTS:Schizophrenia patients, but not relatives, showed a behavioral deficit in sustained attention. During target detection, relatives exhibited diminished late positive amplitudes (P3b, i.e., P300) over parietal brain regions and augmented early posterior (P1) and right frontal (anterior N1) potentials. Electrophysiological anomalies were still evident after the exclusion of three relatives with histories of psychosis. CONCLUSIONS:Genetic liability for schizophrenia is associated with augmented early and diminished late brain potentials during sustained attention. Electrophysiological anomalies suggestive of right frontal-posterior parietal dysfunction might represent neural expression of genetic liability for schizophrenia. Electrophysiological indices also seem to be more sensitive than behavioral measures in assessing genetic liability for schizophrenia.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Sponheim SR,McGuire KA,Stanwyck JJdoi
10.1016/j.biopsych.2005.11.017subject
Has Abstractpub_date
2006-08-01 00:00:00pages
242-52issue
3eissn
0006-3223issn
1873-2402pii
S0006-3223(05)01440-Xjournal_volume
60pub_type
杂志文章abstract::In crossover design with alternate assignment to order, 18 hyperkinetic children were treated with eyes-open rotational vestibular stimulation and with control contact, each eight times over 4-week periods. On behavioral ratings by teachers, they scored better after eight sessions of rotational stimulation than after ...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
doi:10.1016/0006-3223(91)90305-6
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doi:
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pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Biological psychiatry
pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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