Delayed skin hypersensitivity reactions to human brain S-100 protein in psychiatric patients.

abstract：BACKGROUND:In a single-center, placebo-controlled study, topiramate reduced binge eating and weight in patients with binge eating disorder (BED) and obesity. The current investigation evaluated the safety and efficacy of topiramate in a multicenter, placebo-controlled trial. METHODS:Eligible patients between 18 and 65...

journal_title：Biological psychiatry

authors： McElroy SL,Hudson JI,Capece JA,Beyers K,Fisher AC,Rosenthal NR,Topiramate Binge Eating Disorder Research Group.

更新日期：2007-05-01 00:00:00

abstract：:Previous studies have suggested that tardive dyskinesia may occur more frequently in patients who smoke. Further evidence of an interaction between smoking and movement disorders includes the low lifetime exposure to cigarettes found in Parkinson's disease patients. In this study 126 patients with chronic psychiatric ...

journal_title：Biological psychiatry

authors： Menza MA,Grossman N,Van Horn M,Cody R,Forman N

更新日期：1991-07-15 00:00:00

abstract：BACKGROUND:The magnitude of the startle eyeblink response is reduced if the startle eliciting stimulus is shortly preceded by another stimulus. There is evidence that schizophrenia patients exhibit impairments in this so-called prepulse inhibition. Our study investigated whether prepulse inhibition is affected by neuro...

journal_title：Biological psychiatry

authors： Weike AI,Bauer U,Hamm AO

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Intracellular deposition of tau protein is a hallmark lesion of Alzheimer's disease. Although it is known this event is secondary to excessive tau phosphorylation, the mechanisms involved remain unknown. We previously reported that the enzyme 5-Lipoxygenase (5LO) acts as a modulator of Aβ peptides formation ...

journal_title：Biological psychiatry

authors： Chu J,Li JG,Ceballos-Diaz C,Golde T,Praticò D

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Social phobia has been characterized as a disorder of exaggerated fear of social threat and heightened sensitivity to imagery of social failure. METHODS:To assess the physiological basis of this description, social phobia patients (n=75) and demographically matched control participants (n=75) imagined neutr...

journal_title：Biological psychiatry

authors： McTeague LM,Lang PJ,Laplante MC,Cuthbert BN,Strauss CC,Bradley MM

更新日期：2009-03-01 00:00:00

abstract：:A broad definition of sensory gating refers to the ability of the brain to modulate its sensitivity to incoming sensory stimuli. This definition allows the concept of gating to include both the capacities to minimize or stop responding to incoming irrelevant stimuli (gating out) and to respond when a novel stimulus is...

journal_title：Biological psychiatry

authors： Boutros NN,Belger A

更新日期：1999-04-01 00:00:00

abstract：:Methysergide a clinically used blocker of serotonin receptors, was given for 48 hr to 11 normal adults, at a dose of 8 mg per 24 hr. Total REM sleep time was decreased, although total sleep time was unchanged. Stage 4 decreased and stage 3 increased, while total slow wave sleep remained constant. There was a tendency ...

journal_title：Biological psychiatry

authors： Mendelson WB,Reichman J,Othmer E

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Previous studies demonstrate that indirect activation of monoamine receptors by antidepressant treatment increases neurotrophic factors that activate the mitogen-activated protein kinase cascade; however, it is also possible that these monoamine receptors influence the mitogen-activated protein kinase pathwa...

journal_title：Biological psychiatry

authors： Tolbert LM,Russell DS,Duman RS

更新日期：2003-11-15 00:00:00

abstract：BACKGROUND:Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy. METHODS:This 10-week, acute, randomized, controlled, masked trial compared adjunc...

journal_title：Biological psychiatry

authors： Rush AJ,Marangell LB,Sackeim HA,George MS,Brannan SK,Davis SM,Howland R,Kling MA,Rittberg BR,Burke WJ,Rapaport MH,Zajecka J,Nierenberg AA,Husain MM,Ginsberg D,Cooke RG

更新日期：2005-09-01 00:00:00

abstract：:The history of psychiatric research is filled with widely accepted etiologic and pathophysiologic theories that eventually were proven wrong. The prevailing pathophysiologic theories of schizophrenia have emphasized the role of abnormal neurodevelopment in determining the onset and course of the illness. Relatively li...

journal_title：Biological psychiatry

authors： Lieberman JA

更新日期：1999-09-15 00:00:00

abstract：BACKGROUND:Previous neuroimaging studies have demonstrated exaggerated amygdala responses to negative stimuli in posttraumatic stress disorder (PTSD). The time course of this amygdala response is largely unstudied and is relevant to questions of habituation and sensitization in PTSD exposure therapy. METHODS:We applie...

journal_title：Biological psychiatry

authors： Protopopescu X,Pan H,Tuescher O,Cloitre M,Goldstein M,Engelien W,Epstein J,Yang Y,Gorman J,LeDoux J,Silbersweig D,Stern E

更新日期：2005-03-01 00:00:00

abstract：:The uptake of L-tryptophan by chicken erythrocytes is stimulated by the presence of human plasma; however, there is no difference between the stimulation caused by plasmas of normal, chronic hospitalized nonschizophrenic, or chronic hospitalized schizophrenic subjects. Human plasma in general contains a complement-dep...

journal_title：Biological psychiatry

authors： Guchhait RB,Janson C,Price WH

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND:Despite cognitive function impairment in depression, its relationship to treatment outcome is not well understood. Here, we examined whether pretreatment activation of cortical circuitry during test of cognitive functions predicts outcomes for three commonly used antidepressants. METHODS:Eighty medication-f...

journal_title：Biological psychiatry

authors： Gyurak A,Patenaude B,Korgaonkar MS,Grieve SM,Williams LM,Etkin A

更新日期：2016-02-15 00:00:00

abstract：:Postmortem cerebellar and frontal cortical membrane homogenates from human alcoholics, control subjects without neurological or psychiatric illnesses, and rats that chronically drank alcohol were studied to determine the binding characteristics of an imidazobenzodiazepine, [3H]Ro 15-4513. This ligand binds to classica...

journal_title：Biological psychiatry

authors： Korpi ER,Uusi-Oukari M,Wegelius K,Casanova M,Zito M,Kleinman JE

更新日期：1992-04-15 00:00:00

abstract：BACKGROUND:A facial discrimination task was adapted to be used in an event-related potential (ERP) paradigm in order to evaluate whether young women's brain responses to affective stimuli differed from those of young men. METHODS:The stimuli used to generate a late positive component of the ERP, designated the "P450,"...

journal_title：Biological psychiatry

authors： Orozco S,Ehlers CL

更新日期：1998-08-15 00:00:00

abstract：:There has been an explosion of research on fear extinction in humans in the past 2 decades. This has not only generated major insights, but also brought a new goal into focus: how to maintain extinction memory over time (i.e., extinction retention). We argue that there are still important conceptual and procedural cha...

journal_title：Biological psychiatry

authors： Lonsdorf TB,Merz CJ,Fullana MA

更新日期：2019-06-15 00:00:00

abstract：:Athina Markou and others argue forcefully for the adoption of a "translational-back translational strategy" for central nervous system drug discovery involving novel application of drugs with established safety profiles in proof-of-principle studies in humans, which in turn encourage parallel studies using experimenta...

journal_title：Biological psychiatry

authors： Phillips AG,Geyer MA,Robbins TW

更新日期：2018-06-01 00:00:00

abstract：:Lithium-treated and drug-free individuals were each given 0.5 mg epinephrine subcutaneously and blood samples withdrawn for measurement of plasma cyclic AMP and cyclic GMP. The rise in plasma cyclic GMP in response to epinephrine was found to be partially inhibited by lithium treatment, and previous reports of lithium...

journal_title：Biological psychiatry

authors： Belmaker RH,Kon M,Ebstein RP,Dasberg H

更新日期：1980-02-01 00:00:00

abstract：BACKGROUND:Neuropsychological studies in subjects with eating disorders (EDs) have reported conflicting findings, which might be accounted for by several confounding variables, including neuroendocrine changes. METHODS:General abilities, executive functions, attention, and noneffortful learning were assessed in 45 pat...

journal_title：Biological psychiatry

authors： Galderisi S,Mucci A,Monteleone P,Sorrentino D,Piegari G,Maj M

更新日期：2003-05-15 00:00:00

abstract：BACKGROUND:Although intimate partner violence (IPV) has a great impact on women's health, few studies have assessed the consequences on physiologic responses. METHODS:Women abused by their intimate male partners either physically (n = 70) or psychologically (n = 46) were compared with nonabused control women (n = 46)....

journal_title：Biological psychiatry

authors： Pico-Alfonso MA,Garcia-Linares MI,Celda-Navarro N,Herbert J,Martinez M

更新日期：2004-08-15 00:00:00

abstract：BACKGROUND:Accurate recognition of facial expressions is crucial for social functioning. In depressed individuals, implicit and explicit attentional biases away from happy and toward sad stimuli have been demonstrated. These may be associated with the negative cognitions in these individuals. METHODS:Using event-relat...

journal_title：Biological psychiatry

authors： Surguladze S,Brammer MJ,Keedwell P,Giampietro V,Young AW,Travis MJ,Williams SC,Phillips ML

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:The current study directly investigated whether changes in the neural correlates of self-regulation (SR) are associated with the effectiveness of treatment for the externalizing problems of children. METHODS:Seventy-one children 8-12 years of age with clinical levels of externalizing behavior and their fami...

journal_title：Biological psychiatry

authors： Woltering S,Granic I,Lamm C,Lewis MD

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Stimulation of alpha(2)-adrenergic receptors (alpha(2)-ARs) in the prefrontal cortex (PFC) has a beneficial effect on working memory and attentional regulation in monkeys. alpha(2)-adrenergic agonists like clonidine and guanfacine have been used experimentally and clinically for the treatment of attention de...

journal_title：Biological psychiatry

authors： Ma CL,Arnsten AF,Li BM

更新日期：2005-01-15 00:00:00

abstract：:We studied 10 subjects each with melancholic depression evidencing significant motor retardation (RM), Parkinson's disease (PD) with bradykinesia, and normal healthy controls (NC), matched closely for age and gender, on measurements of motor function and depression, and their performance of simple and complex ballisti...

journal_title：Biological psychiatry

authors： Sachdev P,Aniss AM

更新日期：1994-02-15 00:00:00

abstract：:Plasma norepinephrine (NE), free 3-methoxy-4-hydroxyphenethylene glycol (MHPG), and binding of tritiated yohimbine to platelet membranes were measured in 14 patients with generalized anxiety disorder (GAD), who were matched for age and sex with 14 patients with unipolar major depressive disorder (MDD) and 14 normal su...

journal_title：Biological psychiatry

authors： Sevy S,Papadimitriou GN,Surmont DW,Goldman S,Mendlewicz J

更新日期：1989-01-15 00:00:00

abstract：BACKGROUND:The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptic drugs is a major challenge. Clozapine has been one treatment option; however, it is not universally effective and is limited in its use by safety concerns. With the introduction of newer agents, their performance re...

journal_title：Biological psychiatry

authors： Tollefson GD,Birkett MA,Kiesler GM,Wood AJ,Lilly Resistant Schizophrenia Study Group.

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:22q11.2 deletions and duplications are copy number variations (CNVs) that predispose to developmental neuropsychiatric disorders. Both CNVs are associated with autism spectrum disorder (ASD), while the deletion confers disproportionate risk for schizophrenia. Neurobehavioral profiles associated with these re...

journal_title：Biological psychiatry

authors： Lin A,Vajdi A,Kushan-Wells L,Helleman G,Hansen LP,Jonas RK,Jalbrzikowski M,Kingsbury L,Raznahan A,Bearden CE

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Endocytic dysfunction and neurotrophin signaling deficits may underlie the selective vulnerability of hippocampal neurons during the progression of Alzheimer's disease (AD), although there is little direct in vivo and biochemical evidence to support this hypothesis. METHODS:Microarray analysis of hippocampa...

journal_title：Biological psychiatry

authors： Ginsberg SD,Alldred MJ,Counts SE,Cataldo AM,Neve RL,Jiang Y,Wuu J,Chao MV,Mufson EJ,Nixon RA,Che S

更新日期：2010-11-15 00:00:00

abstract：:Potential recovery of electrophysiological and neuropsychological functions was investigated in alcoholics completing treatment and controls. Event-related potentials (ERPs) and neuropsychological tests were administered initially and repeated 14 months later. Alcoholics were classified as resumers or abstainers based...

journal_title：Biological psychiatry

authors： Glenn S,Parsons OA,Sinha R

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Neurobiologic abnormalities in the thalamus have been implicated in the pathophysiology of obsessive-compulsive disorder. We recently reported increased thalamic volume in treatment-naive pediatric obsessive-compulsive disorder patients versus case-matched healthy comparison subjects that decreased to levels...

journal_title：Biological psychiatry

authors： Rosenberg DR,Benazon NR,Gilbert A,Sullivan A,Moore GJ

更新日期：2000-08-15 00:00:00