Benzodiazepines counteract rostral anterior cingulate cortex activation induced by cholecystokinin-tetrapeptide in humans.

Abstract:

BACKGROUND:Benzodiazepines modulate γ-aminobutyric acid type A (GABA(A)) receptors throughout the brain. However, it is not fully understood which brain regions within anxiety-related brain circuits are really responsible for their anxiolytic effects and how these regions interact. METHODS:We investigated whether the benzodiazepine alprazolam affects activity in distinct brain regions within anxiety-related circuits during an experimental anxiety paradigm by means of functional magnetic resonance imaging (fMRI). Panic symptoms were elicited by a bolus injection of the neuropeptide cholecystokinin-tetrapeptide (CCK-4) in 16 healthy male subjects in a double-blind, placebo-controlled design. Functional brain activation patterns were determined before and during the CCK-4-challenge without pretreatment and after treatment with either placebo or 1 mg alprazolam. RESULTS:The CCK-4 induced anxiety and elicited widely distributed activation patterns in anxiety-related brain circuits, especially in the rostral anterior cingulate cortex (rACC), which was attenuated after alprazolam treatment. In contrast to placebo, alprazolam abolished the activation of the rACC after challenge with CCK-4 (p<.005, corrected for multiple comparisons) and increased functional connectivity between the rACC and other anxiety-related brain regions such as amygdala and prefrontal cortex. Moreover, the reduction in the CCK-4 induced activation of the rACC correlated with the anxiolytic effect of alprazolam (r(p) = .52; p = .04). CONCLUSIONS:These findings put forward the rACC as a target for benzodiazepines and suggest that the CCK-4/fMRI paradigm might represent a human translational model for the investigation of anxiolytic drugs.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Leicht G,Mulert C,Eser D,Sämann PG,Ertl M,Laenger A,Karch S,Pogarell O,Meindl T,Czisch M,Rupprecht R

doi

10.1016/j.biopsych.2012.09.004

subject

Has Abstract

pub_date

2013-02-15 00:00:00

pages

337-44

issue

4

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(12)00775-5

journal_volume

73

pub_type

杂志文章
  • Event-related potential correlates of impaired selective attention in children at high risk for schizophrenia.

    abstract::Auditory event-related potentials (ERPs) associated with selective attention were recorded in 21 children at high-risk for schizophrenia and in 21 matched controls. The subjects performed a selective listening task. For behavioral evaluation, target counts on the selective listening task and on cognitive performance w...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(92)90294-a

    authors: Schreiber H,Stolz-Born G,Kornhuber HH,Born J

    更新日期:1992-10-15 00:00:00

  • Fluoxetine and neuroleptic malignant syndrome.

    abstract::The authors present a case report of neuroleptic malignant syndrome (NMS) in a patient commencing treatment with fluoxetine alone who had previously been treated with several antipsychotic and antidepressant combinations. On reviewing the literature on the pathogenesis of NMS, the authors hypothesize a facilitative ro...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(90)90485-k

    authors: Halman M,Goldbloom DS

    更新日期:1990-09-15 00:00:00

  • The functional neuroanatomy of anxiety: a study of three disorders using positron emission tomography and symptom provocation.

    abstract::Previous neuroimaging research has contributed insights regarding the neural substrates of specific psychiatric disorders. The purpose of this study was to determine the shared mediating neuroanatomy of anxiety symptoms across three different anxiety disorders. Data were pooled from 23 right-handed adult outpatients m...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/S0006-3223(97)00145-5

    authors: Rauch SL,Savage CR,Alpert NM,Fischman AJ,Jenike MA

    更新日期:1997-09-15 00:00:00

  • Methamphetamine-associated memory is regulated by a writer and an eraser of permissive histone methylation.

    abstract:BACKGROUND:Memories associated with drugs of abuse, such as methamphetamine (METH), increase relapse vulnerability to substance use disorder by triggering craving. The nucleus accumbens (NAc) is essential to these drug-associated memories, but underlying mechanisms are poorly understood. Posttranslational chromatin mod...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2013.09.014

    authors: Aguilar-Valles A,Vaissière T,Griggs EM,Mikaelsson MA,Takács IF,Young EJ,Rumbaugh G,Miller CA

    更新日期:2014-07-01 00:00:00

  • Toxic ictal delirium.

    abstract::Delirium, also known as acute confusional state, is a common reversible organic psychiatric syndrome. This paper focuses on toxic delirium associated with prominent paroxysmal electroencephalogram (EEG) dysfunction occurring in nonepileptic patients. Our data derive from observations in two conditions, viz., delirium ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(89)90198-4

    authors: van Sweden B,Mellerio F

    更新日期:1989-02-15 00:00:00

  • IRB review of psychiatric medication discontinuation and symptom-provoking studies.

    abstract::Federal regulations governing human subjects research call for additional protections for the "mentally disabled." However, there is currently no consensus definition of mental disability or guidelines for how these research subjects should be protected. This ambiguity complicates the work of institutional review boar...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(99)00168-7

    authors: Rosenstein DL

    更新日期:1999-10-15 00:00:00

  • Enhanced orbitofrontal cortex function and lack of attentional bias to cocaine cues in recreational stimulant users.

    abstract:BACKGROUND:Although cocaine is known to be a highly addictive drug, there appears to be a select subset of individuals who are able to use the substance recreationally without developing dependence. These individuals do not report experiencing feelings of craving for cocaine, an important distinction from dependent use...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2013.05.019

    authors: Smith DG,Simon Jones P,Bullmore ET,Robbins TW,Ersche KD

    更新日期:2014-01-15 00:00:00

  • Neurochemical changes in rat brain amines after short- and long-term inhibition of monoamine oxidase by a low dose of tranylcypromine.

    abstract::The effects of short- and long-term administration of a low dose of tranylcypromine on brain and urine levels of several biogenic amines and on brain activity of monoamine oxidases (MAO) A and B were investigated. MAO-A and MAO-B were inhibited by greater than 85% on day 1, and this inhibition continued to increase ov...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(88)90033-9

    authors: Hampson DR,Baker GB,Coutts RT

    更新日期:1988-02-01 00:00:00

  • Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial.

    abstract:BACKGROUND:Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy. METHODS:This 10-week, acute, randomized, controlled, masked trial compared adjunc...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.biopsych.2005.05.025

    authors: Rush AJ,Marangell LB,Sackeim HA,George MS,Brannan SK,Davis SM,Howland R,Kling MA,Rittberg BR,Burke WJ,Rapaport MH,Zajecka J,Nierenberg AA,Husain MM,Ginsberg D,Cooke RG

    更新日期:2005-09-01 00:00:00

  • Regional prefrontal gray and white matter abnormalities in bipolar disorder.

    abstract:BACKGROUND:Previous magnetic resonance imaging (MRI) studies indicate that compared with healthy volunteers, patients with bipolar disorder have structural and functional abnormalities in the prefrontal cortex. The aim of this study was to investigate differences in prefrontal subregions between bipolar patients and he...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(02)01350-1

    authors: López-Larson MP,DelBello MP,Zimmerman ME,Schwiers ML,Strakowski SM

    更新日期:2002-07-15 00:00:00

  • Limbic/mesolimbic connections and the pathogenesis of schizophrenia.

    abstract::The development of models of the pathogenesis of neuropsychiatric diseases that build on recent advances in chemical neuroanatomy will help to guide future research. The interconnections among limbic, basal ganglia, and cortical structures are used to form the basis of a hypothesis of the pathogenesis of schizophrenia...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/0006-3223(91)90295-w

    authors: Csernansky JG,Murphy GM,Faustman WO

    更新日期:1991-08-15 00:00:00

  • Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1.

    abstract:BACKGROUND:No opioid receptor, mu 1 (OPRM1) gene polymorphisms, including the functional single nucleotide polymorphism (SNP) rs1799971, have been conclusively associated with heroin/other opioid addiction, despite their biological plausibility. We used evidence of polymorphisms altering OPRM1 expression in normal huma...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.biopsych.2015.01.003

    authors: Hancock DB,Levy JL,Gaddis NC,Glasheen C,Saccone NL,Page GP,Hulse GK,Wildenauer D,Kelty EA,Schwab SG,Degenhardt L,Martin NG,Montgomery GW,Attia J,Holliday EG,McEvoy M,Scott RJ,Bierut LJ,Nelson EC,Kral AH,Johnson EO

    更新日期:2015-10-01 00:00:00

  • Increased association of brain protein kinase C with the receptor for activated C kinase-1 (RACK1) in bipolar affective disorder.

    abstract:BACKGROUND:Membrane protein kinase C (PKC) activity is increased in frontal cortex of subjects with bipolar affective disorder, and lithium was demonstrated to inhibit PKC translocation to membranes. Protein kinase C is anchored to the membrane via the receptor for activated C kinase-1 (RACK1), suggesting that interact...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(01)01147-7

    authors: Wang H,Friedman E

    更新日期:2001-09-01 00:00:00

  • Pretreatment brain states identify likely nonresponse to standard treatments for depression.

    abstract:BACKGROUND:Treatment approaches for major depressive disorder (MDD) result in approximately one third of patients achieving remission after a first treatment. Added treatment generally improves remission rates, but approximately one third of all patients fail to respond after several treatments (sequential monotherapie...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.biopsych.2013.12.005

    authors: McGrath CL,Kelley ME,Dunlop BW,Holtzheimer PE 3rd,Craighead WE,Mayberg HS

    更新日期:2014-10-01 00:00:00

  • Concurrent assessment of acoustic startle and auditory P50 evoked potential measures of sensory inhibition.

    abstract::The acoustic startle response (ASR) and midlatency auditory evoked potentials (AEP) have been utilized in the measurement of sensory inhibition. Using these different paradigms, abnormalities suggesting a lack of normal inhibition have been noted in a number of psychiatric syndromes. To date, the most commonly used se...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(93)90023-7

    authors: Schwarzkopf SB,Lamberti JS,Smith DA

    更新日期:1993-06-01 00:00:00

  • Norepinephrine activates extracellular-regulated kinase in cortical neurons.

    abstract:BACKGROUND:Previous studies demonstrate that indirect activation of monoamine receptors by antidepressant treatment increases neurotrophic factors that activate the mitogen-activated protein kinase cascade; however, it is also possible that these monoamine receptors influence the mitogen-activated protein kinase pathwa...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(03)00346-9

    authors: Tolbert LM,Russell DS,Duman RS

    更新日期:2003-11-15 00:00:00

  • Monoamine oxidase A and B activities in heavy smokers.

    abstract::There is a strong association between depression and smoking. Because monoamine oxidase (MAO) inhibition leads to antidepressant effect and in vitro studies have shown that cigarette smoke inhibits MAO activity, it is conceivable that smoking may have an antidepressant effect, if smokers have reduced MAO activity. The...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/0006-3223(95)00084-4

    authors: Berlin I,Said S,Spreux-Varoquaux O,Olivares R,Launay JM,Puech AJ

    更新日期:1995-12-01 00:00:00

  • Cerebellar and frontal cortical benzodiazepine receptors in human alcoholics and chronically alcohol-drinking rats.

    abstract::Postmortem cerebellar and frontal cortical membrane homogenates from human alcoholics, control subjects without neurological or psychiatric illnesses, and rats that chronically drank alcohol were studied to determine the binding characteristics of an imidazobenzodiazepine, [3H]Ro 15-4513. This ligand binds to classica...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(92)90309-n

    authors: Korpi ER,Uusi-Oukari M,Wegelius K,Casanova M,Zito M,Kleinman JE

    更新日期:1992-04-15 00:00:00

  • Serum thyroxine change and clinical recovery in psychiatric inpatients.

    abstract::Serum free thyroxine (FT4), total thyroxine (TT4), and Brief Psychiatric Rating Scale (BPRS) measurements were obtained following hospital admission and at 2-week intervals during hospitalization in 80 male psychiatric inpatients with a variety of major psychotic and affective disorders. A strong correlation between t...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(89)90148-0

    authors: Southwick S,Mason JW,Giller EL,Kosten TR

    更新日期:1989-01-01 00:00:00

  • Electroencephalographic activity and plasma ACTH during ethanol-induced euphoria.

    abstract::Covariance of brain electrical activity (EEG), plasma adrenocorticotrophic hormone (ACTH) and cortisol levels, and mood states were determined for healthy adult men during the first 2 hr after ingestion of ethanol or ethanol placebo under controlled double-blind conditions. Analysis of integrated plasma ACTH and corti...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/0006-3223(88)90084-4

    authors: Lukas SE,Mendelson JH

    更新日期:1988-01-15 00:00:00

  • Psychophysiological and subjective indicators of aversive pavlovian conditioning in generalized social phobia.

    abstract::Aversive conditioning has been proposed as an important etiologic mechanism in social phobia; however, empirical evidence is scarce and has not relied on a detailed analysis of the acquisition and extinction of the conditioned emotional response. Fourteen men sustaining generalized social phobia and 19 healthy control...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(02)01385-9

    authors: Hermann C,Ziegler S,Birbaumer N,Flor H

    更新日期:2002-08-15 00:00:00

  • Time-of-day variations of indicators of attention: performance, physiologic parameters, and self-assessment of sleepiness.

    abstract:BACKGROUND:A study was performed to analyze time-of-day variations of different indicators of attention and their interrelations. METHODS:After a sufficiently long all-night sleep 12 healthy non-sleep-deprived subjects ran through a test battery (Stanford Sleepiness Scale, Visual Analogue Scale, Critical Flicker Fusio...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(00)00908-2

    authors: Kraemer S,Danker-Hopfe H,Dorn H,Schmidt A,Ehlert I,Herrmann WM

    更新日期:2000-12-01 00:00:00

  • Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? An animal model.

    abstract::Adrenocorticosteroids and serotonergic neurons exert reciprocal regulatory actions, and both are abnormal in depression. We evaluated whether glucocorticoids influence the serotonin transporter in rat platelets and brain by infusing dexamethasone for 26 days, sufficient for replacement of the entire platelet populatio...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(95)00469-6

    authors: Slotkin TA,McCook EC,Ritchie JC,Seidler FJ

    更新日期:1996-10-01 00:00:00

  • Hypothalamic serotonin in control of eating behavior, meal size, and body weight.

    abstract::Serotonin (5-HT) has been implicated in the control of eating behavior and body weight. Stimulants of this monoamine reduce food intake and weight gain and increase energy expenditure, both in animals and in humans. This article reviews evidence that supports a role for hypothalamic serotonergic receptor mechanisms in...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/s0006-3223(98)00186-3

    authors: Leibowitz SF,Alexander JT

    更新日期:1998-11-01 00:00:00

  • Effects of light treatment on core body temperature in seasonal affective disorder.

    abstract::Abnormalities in circadian rhythms of core body temperature have been reported previously in depressed patients. In this study, we compared the temperature rhythms of 10 depressed seasonal affective disorder (SAD) patients with winter depression with those of 12 normal controls and evaluated the effects of bright ligh...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(90)90018-w

    authors: Rosenthal NE,Levendosky AA,Skwerer RG,Joseph-Vanderpool JR,Kelly KA,Hardin T,Kasper S,DellaBella P,Wehr TA

    更新日期:1990-01-01 00:00:00

  • Pharmacotherapy of depressed children and adolescents: current issues and potential directions.

    abstract::The recent deliberations by the U.S. Food and Drug Administration (FDA) regarding the relationship between antidepressants and suicidality in children have incited debates about the safety of these medications for the treatment of pediatric depression. In light of these events, this review discusses four issues pertai...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.biopsych.2005.10.010

    authors: Vasa RA,Carlino AR,Pine DS

    更新日期:2006-06-01 00:00:00

  • Brainstem correlates of defensive states in humans.

    abstract:BACKGROUND:Brainstem auditory evoked potentials (BAEP) reflect the activation of brainstem nuclei in the first milliseconds after presentation of an auditory stimulus. These electrophysiological correlates of neural processing are highly automatic and not influenced by cognitive factors or task demands; however, data f...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2005.09.009

    authors: Baas JM,Milstein J,Donlevy M,Grillon C

    更新日期:2006-04-01 00:00:00

  • Effectiveness of chromium in atypical depression: a placebo-controlled trial.

    abstract:BACKGROUND:Chromium picolinate (CP) has been reported to benefit patients with symptoms of atypical depression. METHODS:A placebo-controlled, double-blind, pilot study of CP was conducted in 15 patients with DSM-IV major depressive disorder, atypical type. Patients received 600 micro g of CP or matching placebo (PBO) ...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0006-3223(02)01500-7

    authors: Davidson JR,Abraham K,Connor KM,McLeod MN

    更新日期:2003-02-01 00:00:00

  • Histochemical changes in the blood cells of schizophrenic patients under pimozide treatment.

    abstract::Chromatin structure and nucleohistone pattern were investigated histochemically in the neutrophils of 11 schizophrenics and 16 healthy controls. Compared to controls, all schizophrenic parents prior to medication showed a distinctly different histochemical pattern consisting of increased concentration and abnormal dis...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:

    authors: Stefanis CN,Issidorides MR

    更新日期:1976-02-01 00:00:00

  • Event-related potential evidence of dysfunction in automatic processing in abstinent alcoholics.

    abstract::The preattentive automatic processing of 63 alcoholics and 27 controls was evaluated with an auditory inattentive event-related oddball paradigm. We examined the mismatch negativity and the N2-P3 complex. Results showed significantly greater amplitude for N2, P3 and the N2-P3 complex for controls but no individual lea...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(93)90097-w

    authors: Realmuto G,Begleiter H,Odencrantz J,Porjesz B

    更新日期:1993-04-15 00:00:00