A Common Polymorphism in a Williams Syndrome Gene Predicts Amygdala Reactivity and Extraversion in Healthy Adults.

Abstract:

BACKGROUND:Williams syndrome (WS), a genetic disorder resulting from hemizygous microdeletion of chromosome 7q11.23, has emerged as a model for identifying the genetic architecture of socioemotional behavior. Common polymorphisms in GTF2I, which is found within the WS microdeletion, have been associated with reduced social anxiety in the general population. Identifying neural phenotypes affected by these polymorphisms would help advance our understanding not only of this specific genetic association but also of the broader neurogenetic mechanisms of variability in socioemotional behavior. METHODS:Through an ongoing parent protocol, the Duke Neurogenetics Study, we measured threat-related amygdala reactivity to fearful and angry facial expressions using functional magnetic resonance imaging, assessed trait personality using the Revised NEO Personality Inventory, and imputed GTF2I rs13227433 from saliva-derived DNA using custom Illumina arrays. Participants included 808 non-Hispanic Caucasian, African American, and Asian university students. RESULTS:The GTF2I rs13227433 AA genotype, previously associated with lower social anxiety, predicted decreased threat-related amygdala reactivity. An indirect effect of GTF2I genotype on the warmth facet of extraversion was mediated by decreased threat-related amygdala reactivity in women but not men. CONCLUSIONS:A common polymorphism in the WS gene GTF2I associated with reduced social anxiety predicts decreased threat-related amygdala reactivity, which mediates an association between genotype and increased warmth in women. These results are consistent with reduced threat-related amygdala reactivity in WS and suggest that common variation in GTF2I contributes to broader variability in socioemotional brain function and behavior, with implications for understanding the neurogenetic bases of WS as well as social anxiety.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Swartz JR,Waller R,Bogdan R,Knodt AR,Sabhlok A,Hyde LW,Hariri AR

doi

10.1016/j.biopsych.2015.12.007

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

203-210

issue

3

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(15)01043-4

journal_volume

81

pub_type

杂志文章
  • A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives.

    abstract:BACKGROUND:Recent studies have suggested that there may be a preferential decrease of "nonpyramidal" neurons (NPs) in several corticolimbic regions of schizophrenic (SZ) brain. The current study was undertaken to determine whether a change in the density of pyramidal neurons (PNs) and NPs might be present in the hippoc...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(98)00138-3

    authors: Benes FM,Kwok EW,Vincent SL,Todtenkopf MS

    更新日期:1998-07-15 00:00:00

  • Association between amino acid alterations and hallucinations in alcoholic patients.

    abstract::Because available evidence suggests that alterations in the serotonergic as well as dopaminergic tones underlie hallucinatory activity, we decided to investigate whether serotonin and dopamine pathways are modified in alcoholics with a history of hallucinosis. Brain serotonin has been shown to depend on the plasma rat...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(85)90175-1

    authors: Branchey L,Branchey M,Worner TM,Zucker D,Shaw S,Lieber CS

    更新日期:1985-11-01 00:00:00

  • Streptococcal upper respiratory tract infections and psychosocial stress predict future tic and obsessive-compulsive symptom severity in children and adolescents with Tourette syndrome and obsessive-compulsive disorder.

    abstract:BACKGROUND:One goal of this prospective longitudinal study was to identify new group A beta-hemolytic streptococcal infections (GABHS) in children and adolescents with Tourette syndrome (TS) and/or obsessive-compulsive disorder (OCD) compared with healthy control subjects. We then examined the power of GABHS infections...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2009.08.020

    authors: Lin H,Williams KA,Katsovich L,Findley DB,Grantz H,Lombroso PJ,King RA,Bessen DE,Johnson D,Kaplan EL,Landeros-Weisenberger A,Zhang H,Leckman JF

    更新日期:2010-04-01 00:00:00

  • Disrupted in schizophrenia 1 genotype and positive symptoms in schizophrenia.

    abstract:BACKGROUND:Converging evidence has demonstrated an association between the Disrupted in Schizophrenia 1 (DISC1) gene and schizophrenia (SZ). Within the DISC1 gene, a single nucleotide polymorphism (SNP), Ser704Cys, has been associated with the structure and function of the hippocampus. Because positive symptoms in SZ h...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2006.07.023

    authors: DeRosse P,Hodgkinson CA,Lencz T,Burdick KE,Kane JM,Goldman D,Malhotra AK

    更新日期:2007-05-15 00:00:00

  • EEG-monitored sleep in anorexia nervosa and bulimia.

    abstract::We compared the EEG-monitored sleep of 8 women with anorexia nervosa and 16 normal weight women with bulimia to that of 14 normal women. The patients with anorexia nervosa spent less time asleep and spent less of their sleep time in Stage 1. The sleep of the normal weight patients with bulimia was remarkably similar t...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(85)90191-x

    authors: Walsh BT,Goetz R,Roose SP,Fingeroth S,Glassman AH

    更新日期:1985-09-01 00:00:00

  • Association of the APOE epsilon 4 allele with clinical subtypes of late life depression.

    abstract::The APOE genotypes of 45 elderly inpatients with major depression were determined to investigate the relationship of this disorder to irreversible dementia in late life. We specifically tested the hypothesis that the frequency of the APOE epsilon 4 allele is elevated in depressed elders with cognitive impairment or ps...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(96)00046-7

    authors: Zubenko GS,Henderson R,Stiffler JS,Stabler S,Rosen J,Kaplan BB

    更新日期:1996-11-15 00:00:00

  • Serial DST, TRH test, and TRH-like immunoreactivity measurements in major affective disorders.

    abstract::Neuroendocrine functions in depressed patients with major affective disorders were serially investigated by the Dexamethasone Suppression Test (DST), the thyrotropin-releasing hormone (TRH) stimulation test, and the plasma TRH-like immunoreactivity (TRH-LI) measurement. Prior to antidepressant therapy, the sensitivity...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(87)90184-3

    authors: Itoh N,Matsui N,Fuwano S,Yaginuma H,Miyashita O,Sakai M

    更新日期:1987-05-01 00:00:00

  • Gender differences in electrophysiological responses to facial stimuli.

    abstract:BACKGROUND:A facial discrimination task was adapted to be used in an event-related potential (ERP) paradigm in order to evaluate whether young women's brain responses to affective stimuli differed from those of young men. METHODS:The stimuli used to generate a late positive component of the ERP, designated the "P450,"...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(97)00487-3

    authors: Orozco S,Ehlers CL

    更新日期:1998-08-15 00:00:00

  • Seasonal rhythm of platelet 3H-imipramine binding in normal controls.

    abstract::The densities of platelet 3H-imipramine sites were determined by repetitive measures of 11 normal controls over the course of 1 year. A significant seasonal variation was found, with a circannual peak on February 17 and a nadir on August 18. The estimated amplitude of this rhythm was +/- 599.54 fmol/mg, which fluctuat...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(89)90069-3

    authors: DeMet EM,Chicz-DeMet A,Fleischmann J

    更新日期:1989-09-01 00:00:00

  • Suicide and Alzheimer's pathology in the elderly: a case-control study.

    abstract:BACKGROUND:The single most important risk factor for Alzheimer's pathology is age. Elderly individuals are also at increased risk for suicide, but comprehensive studies of the association between Alzheimer's pathology and suicide are lacking. We designed the current study to determine if Alzheimer's disease changes are...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(00)00952-5

    authors: Rubio A,Vestner AL,Stewart JM,Forbes NT,Conwell Y,Cox C

    更新日期:2001-01-15 00:00:00

  • Brain serotonin 1A receptor binding in bulimia nervosa.

    abstract:BACKGROUND:Selective serotonin reuptake inhibitors (SSRIs) are the first choice for the pharmacologic treatment of bulimia nervosa, but there are no published data on the putative altered serotonin (5-HT) receptor characteristics in patients with bulimia. Experimental studies suggest that the therapeutic antidepressant...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2003.12.016

    authors: Tiihonen J,Keski-Rahkonen A,Löppönen M,Muhonen M,Kajander J,Allonen T,Någren K,Hietala J,Rissanen A

    更新日期:2004-04-15 00:00:00

  • Biochemical plasticity of synaptic transmission: a critical review of Dale's Principle.

    abstract::"Dale's Principle" states that each neuron releases one and only one synaptic transmitter. Mental disorders and behavioral drug effects are attributed to activation or blockade of one or more of these specific transmitters. A series of biochemical, electrophysiological, and behavioral studies suggests the alternative ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审

    doi:

    authors: Sabelli HC,Mosnaim AD,Vazquez AJ,Giardina WJ,Borison RL,Pedemonte WA

    更新日期:1976-08-01 00:00:00

  • Brainstem correlates of defensive states in humans.

    abstract:BACKGROUND:Brainstem auditory evoked potentials (BAEP) reflect the activation of brainstem nuclei in the first milliseconds after presentation of an auditory stimulus. These electrophysiological correlates of neural processing are highly automatic and not influenced by cognitive factors or task demands; however, data f...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2005.09.009

    authors: Baas JM,Milstein J,Donlevy M,Grillon C

    更新日期:2006-04-01 00:00:00

  • De Novo Protein Synthesis Mediated by the Eukaryotic Elongation Factor 2 Is Required for the Anxiolytic Effect of Oxytocin.

    abstract:BACKGROUND:The neuropeptide oxytocin (OXT) mediates its actions, including anxiolysis, via its G protein-coupled OXT receptor. Within the paraventricular nucleus of the hypothalamus (PVN), OXT-induced anxiolysis is mediated, at least in part, via activation of the mitogen-activated protein kinase pathway following calc...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2019.01.010

    authors: Martinetz S,Meinung CP,Jurek B,von Schack D,van den Burg EH,Slattery DA,Neumann ID

    更新日期:2019-05-15 00:00:00

  • The benzodiazepine antagonist Ro 15-1788 does not antagonize the ethanol withdrawal syndrome.

    abstract::It has been suggested that the signs and symptoms of the ethanol withdrawal syndrome may be due to the increased production of an "inverse agonist" that binds to the central benzodiazepine (BZ) recognition site in the brain. Ro 15-1788 (a potent antagonist at the central BZ recognition site), diazepam, and Ro 15-1788 ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(86)90125-3

    authors: Adinoff B,Majchrowicz E,Martin PR,Linnoila M

    更新日期:1986-06-01 00:00:00

  • Memory effects of clomipramine treatment: relationship to CSF monoamine metabolites and drug concentrations in plasma.

    abstract::Performance on tasks tapping automatic and voluntary aspects of memory, attention, and motor speed was examined in 14 patients with major depressive disorder, before and after 3 weeks of treatment with clomipramine (150 mg/day), a potent serotonin and noradrenaline uptake blocker with anticholinergic side effects. Per...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(91)90179-p

    authors: Bartfai A,Asberg M,Mårtensson B,Gustavsson P

    更新日期:1991-12-01 00:00:00

  • G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis.

    abstract::Association of the G72/G30 locus with schizophrenia and bipolar disorder has now been reported in several studies. The G72/G30 locus may be one of several that account for the evidence of linkage that spans a broad region of chromosome 13q. However, the story of G72/G30 is complex. Our meta-analysis of published assoc...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.biopsych.2006.01.019

    authors: Detera-Wadleigh SD,McMahon FJ

    更新日期:2006-07-15 00:00:00

  • Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms.

    abstract:BACKGROUND:Schizophrenia patients exhibit impairment in prepulse inhibition (PPI) of the acoustic startle response (ASR), suggesting a sensorimotor gating deficit. The serotonin-2A receptor (5-HT(2A)R) has been implicated in both the pathogenesis of schizophrenia and the PPI deficits of schizophrenia patients. Moreover...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2008.02.019

    authors: Quednow BB,Kühn KU,Mössner R,Schwab SG,Schuhmacher A,Maier W,Wagner M

    更新日期:2008-09-01 00:00:00

  • Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction.

    abstract:BACKGROUND:Previous work has implicated noradrenergic beta-receptors in the consolidation and reconsolidation of conditioned fear. Less is known, however, about their role in fear expression and extinction. The beta-receptor blocker propranolol has been used clinically to reduce anxiety. With an auditory fear condition...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2009.01.009

    authors: Rodriguez-Romaguera J,Sotres-Bayon F,Mueller D,Quirk GJ

    更新日期:2009-05-15 00:00:00

  • Prediction of the DST results in depressives by means of urinary-free cortisol excretion, dexamethasone levels, and age.

    abstract::This study investigates the relationships between cortisol escape from suppression by dexamethasone during a depressive episode, and the baseline activity of the hypothalamic-pituitary-adrenal (HPA) axis, circulating dexamethasone levels, and age. To this end, we measured urinary-free cortisol (UFC) excretion in 24-hr...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(90)90662-l

    authors: Maes M,Jacobs MP,Suy E,Minner B,Raus J

    更新日期:1990-08-15 00:00:00

  • Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD).

    abstract:BACKGROUND:Early onset of mood symptoms in bipolar disorder has been associated with poor outcome in many studies; however, the factors that might contribute to poor outcome have not been adequately investigated. METHODS:The first consecutive 1000 adult bipolar patients enrolled in the National Institute of Mental Hea...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2004.01.022

    authors: Perlis RH,Miyahara S,Marangell LB,Wisniewski SR,Ostacher M,DelBello MP,Bowden CL,Sachs GS,Nierenberg AA,STEP-BD Investigators.

    更新日期:2004-05-01 00:00:00

  • Posterior hippocampal volumes are associated with remission rates in patients with major depressive disorder.

    abstract:BACKGROUND:The hippocampus (HC) is smaller in patients with recurrent major depressive disorder (MDD), but few longitudinal studies have examined whether volume is associated with clinically meaningful outcomes such as response to treatment. METHODS:We compared regional (head and body/tail) HC volumes in 46 patients w...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2008.06.027

    authors: MacQueen GM,Yucel K,Taylor VH,Macdonald K,Joffe R

    更新日期:2008-11-15 00:00:00

  • Chronic treatment with five different neuroleptics elicits behavioral supersensitivity to opiate infusion into the nucleus accumbens.

    abstract::It has previously been demonstrated that direct opiate infusion into nucleus accumbens elicits psychomotor activation in rats. In the present study, the effects of chronic treatment with five different neuroleptics on this behavioral response were investigated. All neuroleptics tested (haloperidol, sulpiride, flupenti...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(86)90006-5

    authors: Stinus L,Nadaud D,Jauregui J,Kelley AE

    更新日期:1986-01-01 00:00:00

  • Trajectory and Predictors of Depression and Anxiety Disorders in Mothers With the FMR1 Premutation.

    abstract:BACKGROUND:Although the FMR1 premutation is associated with elevated prevalence of psychiatric disorders, the longitudinal course of symptoms has not been established. The present study followed a sample of women with the FMR1 premutation to characterize the incidence, stability, and predictors of mood and anxiety diso...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2015.07.015

    authors: Roberts JE,Tonnsen BL,McCary LM,Ford AL,Golden RN,Bailey DB Jr

    更新日期:2016-05-15 00:00:00

  • Smooth pursuit eye movements, clinical symptoms, CSF metabolites, and skin conductance habituation in schizophrenic patients.

    abstract::Smooth pursuit eye movements (SPEM) for two stimulus velocities (sinusoidal and triangular) were studied by visual inspection in 12 unmedicated RDC-diagnosed schizophrenic patients and in 13 matched controls. SPEM was worse in the patient group and their performance deteriorated with repeated presentations of the task...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:

    authors: Bartfai A,Levander SE,Sedvall G

    更新日期:1983-09-01 00:00:00

  • Further evidence on the effects of vitamin B12 and folate levels on episodic memory functioning: a population-based study of healthy very old adults.

    abstract:BACKGROUND:The relationship between vitamin status and cognitive functioning has been addressed in several recent studies with inconclusive results. The purpose of this study was to examine separate and combined effects of serum vitamin B12 and folic acid on episodic memory functioning in very old age. METHODS:Four st...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(98)00234-0

    authors: Hassing L,Wahlin A,Winblad B,Bäckman L

    更新日期:1999-06-01 00:00:00

  • Impaired attention-dependent augmentation of MMN in nonparanoid vs paranoid schizophrenic patients: a comparison with obsessive-compulsive disorder and healthy subjects.

    abstract::Mismatch negativity (MMN), in the deviant-minus-standard event-related potential (ERP) difference-waveform, may represent a working memory trace of the tone difference. Most but not all studies find MMN reduced in schizophrenic patients. This report investigates if differences may be attributable to experimental condi...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0006-3223(96)00214-4

    authors: Oades RD,Dittmann-Balcar A,Zerbin D,Grzella I

    更新日期:1997-06-15 00:00:00

  • Effective neuroleptic medication removes prepulse inhibition deficits in schizophrenia patients.

    abstract:BACKGROUND:The magnitude of the startle eyeblink response is reduced if the startle eliciting stimulus is shortly preceded by another stimulus. There is evidence that schizophrenia patients exhibit impairments in this so-called prepulse inhibition. Our study investigated whether prepulse inhibition is affected by neuro...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(99)00229-2

    authors: Weike AI,Bauer U,Hamm AO

    更新日期:2000-01-01 00:00:00

  • A study of relationships of serum glucose, insulin, free fatty acids, and free and total tryptophan to mental illness.

    abstract::To explore possible disturbances of cerebral monoamines linked to glucose metabolism, 18 schizophrenics, 21 neurotics, and 21 controls were given a 5-hr glucose tolerance test, and the effect of the glucose load on total and free tryptophan, insulin, and free fatty acids in serum was studied in medication-free patient...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:

    authors: Yaryura-Tobias JA,Chang A,Neziroglu F

    更新日期:1978-04-01 00:00:00

  • Effects of ketamine on thought disorder, working memory, and semantic memory in healthy volunteers.

    abstract:BACKGROUND:The N-methyl-D-aspartate receptor antagonist, ketamine, produces a clinical syndrome of thought disorder, perceptual distortion, and cognitive impairment. METHODS:We have administered ketamine to healthy volunteers to characterize the formal thought disorder and specific memory dysfunction associated with k...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0006-3223(97)00556-8

    authors: Adler CM,Goldberg TE,Malhotra AK,Pickar D,Breier A

    更新日期:1998-06-01 00:00:00