Abstract:
BACKGROUND:Williams syndrome (WS), a genetic disorder resulting from hemizygous microdeletion of chromosome 7q11.23, has emerged as a model for identifying the genetic architecture of socioemotional behavior. Common polymorphisms in GTF2I, which is found within the WS microdeletion, have been associated with reduced social anxiety in the general population. Identifying neural phenotypes affected by these polymorphisms would help advance our understanding not only of this specific genetic association but also of the broader neurogenetic mechanisms of variability in socioemotional behavior. METHODS:Through an ongoing parent protocol, the Duke Neurogenetics Study, we measured threat-related amygdala reactivity to fearful and angry facial expressions using functional magnetic resonance imaging, assessed trait personality using the Revised NEO Personality Inventory, and imputed GTF2I rs13227433 from saliva-derived DNA using custom Illumina arrays. Participants included 808 non-Hispanic Caucasian, African American, and Asian university students. RESULTS:The GTF2I rs13227433 AA genotype, previously associated with lower social anxiety, predicted decreased threat-related amygdala reactivity. An indirect effect of GTF2I genotype on the warmth facet of extraversion was mediated by decreased threat-related amygdala reactivity in women but not men. CONCLUSIONS:A common polymorphism in the WS gene GTF2I associated with reduced social anxiety predicts decreased threat-related amygdala reactivity, which mediates an association between genotype and increased warmth in women. These results are consistent with reduced threat-related amygdala reactivity in WS and suggest that common variation in GTF2I contributes to broader variability in socioemotional brain function and behavior, with implications for understanding the neurogenetic bases of WS as well as social anxiety.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Swartz JR,Waller R,Bogdan R,Knodt AR,Sabhlok A,Hyde LW,Hariri ARdoi
10.1016/j.biopsych.2015.12.007subject
Has Abstractpub_date
2017-02-01 00:00:00pages
203-210issue
3eissn
0006-3223issn
1873-2402pii
S0006-3223(15)01043-4journal_volume
81pub_type
杂志文章abstract:BACKGROUND:Recent studies have suggested that there may be a preferential decrease of "nonpyramidal" neurons (NPs) in several corticolimbic regions of schizophrenic (SZ) brain. The current study was undertaken to determine whether a change in the density of pyramidal neurons (PNs) and NPs might be present in the hippoc...
journal_title:Biological psychiatry
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doi:10.1016/s0006-3223(98)00138-3
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journal_title:Biological psychiatry
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更新日期:2008-11-15 00:00:00
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journal_title:Biological psychiatry
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更新日期:1999-06-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
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journal_title:Biological psychiatry
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更新日期:1978-04-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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