Abstract：
:Recall of dichotically presented digit strings was compared between normal controls and 18 chronic schizophrenic patients tested over 12 weeks on chlorpromazine, placebo, and chlorpromazine reinstatement. Patients were subgrouped according to (i) arousal as indexed by orienting responses in a tone-habituation sequence and (ii) paranoid diagnosis. Digits were of equal intensity or differed by 20 dB between the ears and were reported in any order or one ear before the other. Overall, patients performed as well as controls and withdrawal or reinstatement of drug did not reduce accuracy. Patient-control differences occurred when the louder digits were to be reported second and left-hemisphere inhibitory mechanisms were involved, especially when patients were on chlorpromazine. Some lateralized differences in serial position effects found only in patients were interpreted as reflecting left-hemisphere processing impairments. The more aroused patients showed poorer accuracy than the less aroused group due to reduced recall in the left ear. Paranoid patients had superior recall and showed less shifting of attention away from the right ear than nonparanoids. The results are discussed in the context of neurophysiological theories of brain disturbance in schizophrenia.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Gruzelier JH,Hammond NVsubject
Has Abstractpub_date
1980-10-01 00:00:00pages
759-79issue
5eissn
0006-3223issn
1873-2402journal_volume
15pub_type
临床试验,杂志文章abstract：BACKGROUND:MicroRNAs (miRNAs) are potent regulators of gene expression with proposed roles in brain development and function. We hypothesized that miRNA expression profiles are altered in individuals with severe psychiatric disorders. METHODS:With real-time quantitative polymerase chain reaction, we compared the expre...
journal_title：Biological psychiatry
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更新日期：2011-01-15 00:00:00
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journal_title：Biological psychiatry
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doi：
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journal_title：Biological psychiatry
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pub_type： 杂志文章
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2006-05-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1999-11-15 00:00:00
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pub_type： 杂志文章,meta分析
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更新日期：2013-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2000-01-01 00:00:00
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更新日期：1990-01-15 00:00:00
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更新日期：2002-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1985-09-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
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pub_type： 杂志文章
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.02.030
更新日期：2009-07-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：1998-01-15 00:00:00
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pub_type： 杂志文章
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更新日期：1999-04-01 00:00:00
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更新日期：2001-03-15 00:00:00
