Abstract：
BACKGROUND:The dexamethasone/corticotropin releasing hormone (Dex/CRH) test has been proposed as a potential tool for identifying endophenotypes relevant to mood disorders. Several studies have shown abnormal cortisol reactivity in phenotypically healthy adults without psychiatric disorders as a function of exposure to adverse early environments. METHODS:After a battery of self-report and interview assessments, 230 adults without major Axis I Disorders completed the Dex/CRH test. Childhood maltreatment was evaluated with the Childhood Trauma Questionnaire. Effect of childhood emotional abuse (EA) on cortisol responses to the Dex/CRH test was examined with repeated measures general linear models, including age, gender, and other types of maltreatment. Post hoc models examined the significant interaction between EA and age and tested the stability of the main findings with selected covariates. RESULTS:A history of self-reported childhood EA independently and significantly diminished cortisol response. This effect was amplified with advancing subject age and was independent of the effects of other types of childhood maltreatment, lifetime diagnoses, and symptom scores. CONCLUSIONS:Dampened cortisol reactivity might be a consequence of childhood EA that is cumulative over time. Prospective longitudinal investigation is needed to evaluate the potential of this proposed endophenotype.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Carpenter LL,Tyrka AR,Ross NS,Khoury L,Anderson GM,Price LHdoi
10.1016/j.biopsych.2009.02.030subject
Has Abstractpub_date
2009-07-01 00:00:00pages
69-75issue
1eissn
0006-3223issn
1873-2402pii
S0006-3223(09)00297-2journal_volume
66pub_type
杂志文章abstract：:A meeting on the molecular and neurobiological basis of schizophrenia was held April 11-14, 1999 at the Banbury Center of The Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. This report is a summary of the predominant views of the participants, as perceived by the organizers. The purpose of this meeting w...
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更新日期：2015-01-01 00:00:00
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更新日期：2014-10-01 00:00:00
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pub_type： 杂志文章,meta分析
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2009-06-15 00:00:00
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pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：2004-03-01 00:00:00
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更新日期：2003-01-01 00:00:00
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更新日期：2015-12-15 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：1991-05-15 00:00:00
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
doi：
更新日期：1977-06-01 00:00:00
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更新日期：2010-12-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：1999-01-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.11.013
更新日期：2009-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1999-09-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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