Neuroendocrine effects of ovine corticotropin-releasing hormone in panic disorder patients.

Abstract:

:A number of neuroendocrine abnormalities have been reported in panic disorder patients: the most extensively studied being disturbances of hypothalamic-pituitary-adrenal function (Curtis et al. 1982; Leiberman et al. 1983; Uhde et al. 1988). The recent sequencing and synthesis of corticotropin-releasing hormone now allows direct testing of pituitary responsivity to this neuropeptide in affective and panic disorder patients (Holsboer et al. 1984; Gold et al. 1986; Roy-Byrne et al. 1986; Holsboer et al. 1987; Risch et al. 1988). We report the effects of intravenously administered ovine corticotropin-releasing hormone (0.03 micrograms/kg) on plasma concentrations of adrenocorticotropin hormone (ACTH) and cortisol in a small group of panic disorder patients and age- and sex-matched normal controls.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Rapaport MH,Risch SC,Golshan S,Gillin JC

doi

10.1016/0006-3223(89)90049-8

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

344-8

issue

4

eissn

0006-3223

issn

1873-2402

pii

0006-3223(89)90049-8

journal_volume

26

pub_type

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