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Neural correlates of negative emotionality in borderline personality disorder: an activation-likelihood-estimation meta-analysis.

Abstract：

BACKGROUND:Emotional vulnerabilities at the core of borderline personality disorder (BPD) involve a dysfunction of frontolimbic systems subserving negative emotionality. The specific regions identified in individual studies, however, vary widely and provide an incomplete understanding of the functional brain abnormalities that characterize this illness. A quantitative synthesis of functional neuroimaging studies might clarify the neural systems dysfunctions that underlie negative emotionality in BPD. METHODS:An electronic search of Medline and PsycInfo databases from 2000 to 2012 identified 18 potential studies, of which 11 met inclusion criteria for the meta-analysis and comprised a pooled sample of 154 BPD patients and 150 healthy control subjects. Contrasts of negative versus neutral emotion conditions were analyzed with an activation-likelihood-estimation meta-analytic approach. Group comparisons were performed on study-reported between-subjects contrasts and independent subtraction analyses based on within-subjects contrasts. RESULTS:Healthy control subjects activated a well-characterized network of brain regions associated with processing negative emotions that included the anterior cingulate cortex and amygdala. Compared with healthy control subjects, BPD patients demonstrated greater activation within the insula and posterior cingulate cortex. Conversely, they showed less activation than control subjects in a network of regions that extended from the amygdala to the subgenual anterior cingulate and dorsolateral prefrontal cortex. CONCLUSIONS:Processing of negative emotions in BPD might be subserved by an abnormal reciprocal relationship between limbic structures representing the degree of subjectively experienced negative emotion and anterior brain regions that support the regulation of emotion. Contrary to early studies, BPD patients showed less activation than control subjects in the amygdala under conditions of negative emotionality.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Ruocco AC,Amirthavasagam S,Choi-Kain LW,McMain SF

doi

10.1016/j.biopsych.2012.07.014

subject

Has Abstract

pub_date

2013-01-15 00:00:00

pages

153-60

issue

2

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(12)00626-9

journal_volume

73

pub_type

杂志文章,meta分析

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