Effect of methylphenidate on executive functioning in adults with attention-deficit/hyperactivity disorder: normalization of behavior but not related brain activity.

abstract：:Mood disorders are serious diseases that affect a large portion of the population. There have been many hypotheses put forth over the years to explain the development of major depression, bipolar disorder, and other mood disorders. These hypotheses include disruptions in monoamine transmission, hypothalamus-pituitary-...

journal_title：Biological psychiatry

authors： McClung CA

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:Maintenance treatment to prevent recurrences is recommended for chronic forms of major depressive disorder (MDD), but few studies have examined maintenance efficacy of antidepressants with chronic MDD. This randomized, placebo-controlled study of the efficacy and safety of nefazodone in preventing recurrence...

journal_title：Biological psychiatry

authors： Gelenberg AJ,Trivedi MH,Rush AJ,Thase ME,Howland R,Klein DN,Kornstein SG,Dunner DL,Markowitz JC,Hirschfeld RM,Keitner GI,Zajecka J,Kocsis JH,Russell JM,Miller I,Manber R,Arnow B,Rothbaum B,Munsaka M,Banks P,Borian

更新日期：2003-10-15 00:00:00

abstract：:This review was generated from discussions by the Pharmacologic and Somatic Treatments Section of the National Institute of Mental Health Strategic Plan for Mood Disorders Committee on advancing novel pharmacologic and somatic treatments for mood disorders. The opening section of the article summarizes in broad stroke...

journal_title：Biological psychiatry

authors： Tamminga CA,Nemeroff CB,Blakely RD,Brady L,Carter CS,Davis KL,Dingledine R,Gorman JM,Grigoriadis DE,Henderson DC,B Innis RB,Killen J,Laughren TP,McDonald WM,M Murphy GM Jr,Paul SM,Rudorfer MV,Sausville E,Schatzberg AF

更新日期：2002-09-15 00:00:00

abstract：BACKGROUND:Adenosine A2A receptors (A2AR) modulate dopamine and glutamate signaling and thereby may influence some of the psychomotor and cognitive processes associated with schizophrenia. Because astroglial A2AR regulate the availability of glutamate, we hypothesized that they might play an unprecedented role in some ...

journal_title：Biological psychiatry

authors： Matos M,Shen HY,Augusto E,Wang Y,Wei CJ,Wang YT,Agostinho P,Boison D,Cunha RA,Chen JF

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Elevated levels of plasma C-reactive protein (CRP) have been associated with many diseases including depression, but it remains unclear whether this association is causal. We tested the hypothesis that CRP is causally associated with depression, and compared these results to those for cancer, ischemic heart ...

journal_title：Biological psychiatry

authors： Wium-Andersen MK,Orsted DD,Nordestgaard BG

更新日期：2014-08-01 00:00:00

abstract：:Nuclear transplantation, cell fusion, and induced pluripotent stem cell studies have revealed a surprising degree of plasticity in mature mammalian cell fates. Somatic cell reprogramming also has been achieved more recently by the directed conversion of nonneuronal somatic cells, such as skin fibroblasts, to neuronal ...

journal_title：Biological psychiatry

authors： Qiang L,Inoue K,Abeliovich A

更新日期：2014-06-15 00:00:00

abstract：BACKGROUND:A large number of studies suggest the presence of deficits in dorsolateral prefrontal cortex function during performance of working memory tasks in individuals with schizophrenia. However, working memory deficits may also present in other psychiatric disorders, such as major depression. It is not clear wheth...

journal_title：Biological psychiatry

authors： Barch DM,Sheline YI,Csernansky JG,Snyder AZ

更新日期：2003-03-01 00:00:00

abstract：:The locus coeruleus (LC) is the major noradrenergic nucleus in the brain and innervates large segments of the neuraxis. LC neurons are thought to regulate states of attention and vigilance as well as activity of the sympathetic nervous system. These neurons also have been implicated in the actions of stress, antidepre...

journal_title：Biological psychiatry

authors： Nestler EJ,Alreja M,Aghajanian GK

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:The neural projections from the infralimbic region of the prefrontal cortex to the amygdala are important for the maintenance of conditioned fear extinction. Neurons in this pathway exhibit a unique pattern of structural plasticity that is sex-dependent, but the relationship between the morphologic character...

journal_title：Biological psychiatry

authors： Gruene TM,Roberts E,Thomas V,Ronzio A,Shansky RM

更新日期：2015-08-01 00:00:00

abstract：:Previous neuroimaging research has contributed insights regarding the neural substrates of specific psychiatric disorders. The purpose of this study was to determine the shared mediating neuroanatomy of anxiety symptoms across three different anxiety disorders. Data were pooled from 23 right-handed adult outpatients m...

journal_title：Biological psychiatry

authors： Rauch SL,Savage CR,Alpert NM,Fischman AJ,Jenike MA

更新日期：1997-09-15 00:00:00

abstract：BACKGROUND:One goal of this prospective longitudinal study was to identify new group A beta-hemolytic streptococcal infections (GABHS) in children and adolescents with Tourette syndrome (TS) and/or obsessive-compulsive disorder (OCD) compared with healthy control subjects. We then examined the power of GABHS infections...

journal_title：Biological psychiatry

authors： Lin H,Williams KA,Katsovich L,Findley DB,Grantz H,Lombroso PJ,King RA,Bessen DE,Johnson D,Kaplan EL,Landeros-Weisenberger A,Zhang H,Leckman JF

更新日期：2010-04-01 00:00:00

abstract：:Heterogeneity is a major obstacle in the search for biological substrates in schizophrenia. The positive and negative distinction, even if too simplistic, may improve our understanding of underlying processes. Frontostriatal deficits have been related to negative symptoms, while dysfunction of the dominant temporal lo...

journal_title：Biological psychiatry

authors： Gerez M,Tello A

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Gray and white matter volume deficits have been reported in many structural magnetic resonance imaging (MRI) studies of children with attention-deficit/hyperactivity disorder (ADHD); however, there is a paucity of structural MRI studies of adults with ADHD. This study used voxel based morphometry and applied...

journal_title：Biological psychiatry

authors： Seidman LJ,Biederman J,Liang L,Valera EM,Monuteaux MC,Brown A,Kaiser J,Spencer T,Faraone SV,Makris N

更新日期：2011-05-01 00:00:00

abstract：:In order to evaluate the impact of aging on EEG sleep patterns we investigated the polysomnograms of 74 patients with major depression and 51 healthy volunteers aged 18-65 years. In most of the EEG sleep parameters, age-related changes were obvious in both the depressives and the normals. In the patients, some of thes...

journal_title：Biological psychiatry

authors： Lauer CJ,Riemann D,Wiegand M,Berger M

更新日期：1991-05-15 00:00:00

abstract：:Athina Markou and others argue forcefully for the adoption of a "translational-back translational strategy" for central nervous system drug discovery involving novel application of drugs with established safety profiles in proof-of-principle studies in humans, which in turn encourage parallel studies using experimenta...

journal_title：Biological psychiatry

authors： Phillips AG,Geyer MA,Robbins TW

更新日期：2018-06-01 00:00:00

abstract：:Seven women with histories of puerperal psychosis and four with histories of puerperal major depression were consecutively treated with high-dose oral estrogen immediately following delivery. None of the women had histories of nonpuerperal affective disorder, and all women were affectively well throughout the current ...

journal_title：Biological psychiatry

authors： Sichel DA,Cohen LS,Robertson LM,Ruttenberg A,Rosenbaum JF

更新日期：1995-12-15 00:00:00

abstract：BACKGROUND:Venlafaxine blocks both serotonin and norepinephrine transporters (SERT and NET), with higher affinity for SERT. Serotonergic effects occur with lower doses, whereas both serotonergic and noradrenergic effects occur with higher doses of venlafaxine. Chronic treatment of rats with selective serotonin reuptake...

journal_title：Biological psychiatry

authors： Gould GG,Altamirano AV,Javors MA,Frazer A

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Gastrointestinal (GI) symptoms and abnormalities in stool consistency are frequently reported by parents of children with autism spectrum disorders (ASD). The purpose of this study was to 1) describe dietary intake of a cohort of children with ASD compared with normative data and 2) determine whether GI symp...

journal_title：Biological psychiatry

authors： Levy SE,Souders MC,Ittenbach RF,Giarelli E,Mulberg AE,Pinto-Martin JA

更新日期：2007-02-15 00:00:00

abstract：:Certain investigators have asserted that the illness of anorexia nervosa is a form of hypothalamic disturbance. The relationship between 24-hr urine 3-methoxy-4-hydroxyphenylglycol (MHPG) and dexamethasone suppression tests was examined in 13 female patients with AN diagnosed by RDC. Patients showed a consistent assoc...

journal_title：Biological psychiatry

authors： Gwirtsman HE,Gerner RH

更新日期：1981-10-01 00:00:00

abstract：:The dexamethasone suppression test (DST) and sleep EEG were compared in three different descriptive diagnostic schemes in 70 adult patients with nonpsychotic, unipolar major depressive disorder according to Research Diagnostic Criteria. Endogenous (E)/nonendogenous (NE), primary/secondary, and Winokur's family history...

journal_title：Biological psychiatry

authors： Rush AJ,Giles DE,Roffwarg HP,Parker CR

更新日期：1982-03-01 00:00:00

abstract：:Thirty-nine patients with major depression were studied to determine the differential effects of desipramine (DMI) and fluoxetine (FLU) on thyroid hormones. Twenty-six percent showed some abnormality in baseline thyroid hormone levels. There were no demonstrable differences for any of the thyroid indices from baseline...

journal_title：Biological psychiatry

authors： Shelton RC,Winn S,Ekhatore N,Loosen PT

更新日期：1993-01-15 00:00:00

abstract：BACKGROUND:Thalamic abnormalities resulting in impaired attention and information processing may form a foundation for cognitive and perceptual disturbances in schizophrenia. Measurements of the thalamus in patients with schizophrenia have shown reductions relative to normal comparison subjects. METHODS:In the current...

journal_title：Biological psychiatry

authors： Arciniegas D,Rojas DC,Teale P,Sheeder J,Sandberg E,Reite M

更新日期：1999-05-15 00:00:00

abstract：:We have investigated the dexamethasone suppression of cortisol release in a group of 28 patients with senile dementia of the Alzheimer type (SDAT) after stimulation by physostigmine and clonidine, as compared with basal conditions. All patients but one had previously been evaluated with a depression symptom checklist ...

journal_title：Biological psychiatry

authors： Davous P,Roudier M,Piketty ML,Abramowitz C,Lamour Y

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Bipolar disorder is associated with functional and structural abnormalities in the brain circuits involved in processing emotional stimuli. Although impairments of cognitive function have been found to persist in bipolar patients during periods of euthymic mood, it is not known whether abnormalities in emoti...

journal_title：Biological psychiatry

authors： Harmer CJ,Grayson L,Goodwin GM

更新日期：2002-02-15 00:00:00

abstract：BACKGROUND:GPR88 is an orphan G protein coupled receptor highly enriched in the striatum, and previous studies have focused on GPR88 function in striatal physiology. The receptor is also expressed in other brain areas, and here we examined whether GPR88 function extends beyond striatal-mediated responses. METHODS:We c...

journal_title：Biological psychiatry

authors： Meirsman AC,Le Merrer J,Pellissier LP,Diaz J,Clesse D,Kieffer BL,Becker JA

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Neuroimaging data suggest that deficits in ventral prefrontal cortex (VPFC) function in bipolar disorder (BD) progress during adolescence and young adulthood. However, the developmental trajectory of VPFC morphological abnormalities in BD is unknown. This study investigated potential age-dependent volume abn...

journal_title：Biological psychiatry

authors： Blumberg HP,Krystal JH,Bansal R,Martin A,Dziura J,Durkin K,Martin L,Gerard E,Charney DS,Peterson BS

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Quantitative genetic analysis of basic mouse behaviors is a powerful tool to identify novel genetic phenotypes contributing to neurobehavioral disorders. Here, we analyzed genetic contributions to single-trial, long-term social and nonsocial recognition and subsequently studied the functional impact of an id...

journal_title：Biological psychiatry

authors： Bruining H,Matsui A,Oguro-Ando A,Kahn RS,Van't Spijker HM,Akkermans G,Stiedl O,van Engeland H,Koopmans B,van Lith HA,Oppelaar H,Tieland L,Nonkes LJ,Yagi T,Kaneko R,Burbach JP,Yamamoto N,Kas MJ

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Children with early-onset disruptive behavior disorder (DBD), especially those with callous-unemotional traits, are at risk of developing persistent and severe adult antisocial behavior. One possible underlying mechanism for persistence is deficient reward and loss sensitivity, i.e., deficient incentive proc...

journal_title：Biological psychiatry

authors： Cohn MD,Veltman DJ,Pape LE,van Lith K,Vermeiren RR,van den Brink W,Doreleijers TA,Popma A

更新日期：2015-11-01 00:00:00

abstract：:Women who are of normal weight and have bulimia nervosa exhibit multiple neuroendocrine disturbances. We hypothesized that bingeing and vomiting behavior could be contributory because food consumption in healthy volunteers increases plasma cortisol and prolactin secretion and suppresses growth hormone secretion. Thus,...

journal_title：Biological psychiatry

authors： Weltzin TE,McConaha C,McKee M,Hsu LK,Perel J,Kaye WH

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Intracellular deposition of tau protein is a hallmark lesion of Alzheimer's disease. Although it is known this event is secondary to excessive tau phosphorylation, the mechanisms involved remain unknown. We previously reported that the enzyme 5-Lipoxygenase (5LO) acts as a modulator of Aβ peptides formation ...

journal_title：Biological psychiatry

authors： Chu J,Li JG,Ceballos-Diaz C,Golde T,Praticò D

更新日期：2013-09-01 00:00:00