Abstract:
:Certain investigators have asserted that the illness of anorexia nervosa is a form of hypothalamic disturbance. The relationship between 24-hr urine 3-methoxy-4-hydroxyphenylglycol (MHPG) and dexamethasone suppression tests was examined in 13 female patients with AN diagnosed by RDC. Patients showed a consistent association between low urine MHPG and failure to suppress to dexamethasone. In addition, family histories of index cases showed a high percentage of relatives with either primary affective disorder or alcoholism. These results are evidence in support of an hypothesis of hypothalamic dysfunction in AN. Furthermore, these biochemical parameters are also found to be abnormal in PAD. These data, coupled with the genetic material, suggest a link between AN and PAD.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Gwirtsman HE,Gerner RHsubject
Has Abstractpub_date
1981-10-01 00:00:00pages
991-5issue
10eissn
0006-3223issn
1873-2402journal_volume
16pub_type
杂志文章abstract::The neuroimaging community has witnessed a paradigm shift in biomarker discovery from using traditional univariate brain mapping approaches to multivariate predictive models, allowing the field to move toward a translational neuroscience era. Regression-based multivariate models (hereafter "predictive modeling") provi...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2020.02.016
更新日期:2020-12-01 00:00:00
abstract::Short-term reduction in plasma tryptophan (tryptophan depletion) produces a relapse of depressive symptoms in 60% of previously depressed patients recently recovered with serotonin reuptake inhibitor treatment. Tryptophan depletion does not consistently increase depressive symptoms in unmedicated depressed patients or...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0006-3223(96)00224-7
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Previous work has implicated noradrenergic beta-receptors in the consolidation and reconsolidation of conditioned fear. Less is known, however, about their role in fear expression and extinction. The beta-receptor blocker propranolol has been used clinically to reduce anxiety. With an auditory fear condition...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2009.01.009
更新日期:2009-05-15 00:00:00
abstract:BACKGROUND:It is widely considered that exposure to maternal cigarette smoking in pregnancy has risk effects on offspring attention-deficit/hyperactivity disorder (ADHD). This view is supported by consistent observations of association. It is, however, impossible to be certain of adequate control for confounding factor...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2009.05.032
更新日期:2009-10-15 00:00:00
abstract::The author presents six cases of pseudodementia of varying degrees of severity that illustrate the difficulty in making purely clinical diagnoses of pseudodementia and demonstrate the usefulness of ECT in this condition in treatment-resistant patients. In addition, issues of cerebral laterality are raised by one case ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1982-12-01 00:00:00
abstract::This study examined the relationship between borderline and impulsive personality traits on the one hand, and monoamine function on the other in 15 women with bulimia nervosa and 15 women with recurrent suicidal behavior. Platelet serotonin (5-HT) and platelet monoamine oxidase (MAO) activity were used as peripheral m...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(95)00384-3
更新日期:1996-08-01 00:00:00
abstract::Magnetic resonance spectroscopy allows investigation of in vivo neurochemical pathology of schizophrenia. "First generation" studies, focusing on phosphorus and proton magnetic resonance spectroscopy, have suggested alterations in membrane phospholipid metabolism and reductions in N-acetyl aspartate in the frontal and...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(00)00940-9
更新日期:2000-09-01 00:00:00
abstract::Our results seem to indicate the existence of a locus in the major histocompatibity complex (MHC) region, correlated to schizophrenic illness and strictly linked to the loci HL-A and MLR. The associations found between these last loci and the disease can probably be explained by a linkage disequilibrium or a selective...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND:Venlafaxine blocks both serotonin and norepinephrine transporters (SERT and NET), with higher affinity for SERT. Serotonergic effects occur with lower doses, whereas both serotonergic and noradrenergic effects occur with higher doses of venlafaxine. Chronic treatment of rats with selective serotonin reuptake...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2005.07.011
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Reduction of precuneus choline acetyltransferase activity co-occurs with greater beta-amyloid (Aβ) in Alzheimer's disease (AD). Whether this cholinergic deficit is associated with alteration in nerve growth factor (NGF) signaling and its relation to Aβ plaque and neurofibrillary tangle (NFT) pathology during...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2013.12.016
更新日期:2015-04-15 00:00:00
abstract:BACKGROUND:Neuregulin-1 (Nrg1) is a pleiotropic signaling molecule that regulates neural development, and mutation of Nrg1 is a risk factor for schizophrenia. Cleavage of type I β1 Nrg1 isoform by Bace1 releases a secreted N-terminal fragment (Nrg1-ntfβ), which can bind to a cognate ErbB receptor to activate the specif...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2013.09.026
更新日期:2014-07-15 00:00:00
abstract:BACKGROUND:Several lines of evidence suggest the presence of abnormalities in the endocannabinoid (eCB) system in schizophrenia (SCZ). However, there are limited in vivo measures of the eCB system in SCZ. METHODS:Twenty five male SCZ subjects (SCZs) (18 antipsychotic treated and 7 antipsychotic free) were compared wit...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2015.08.021
更新日期:2016-06-15 00:00:00
abstract::The effect of individual plasma proteins on the binding of 3H-imipramine (3H-IMI) was investigated, using rat cerebral membranes as the binding site source. Addition of alpha-1-acid glycoprotein (aAGLP) to an incubation medium containing 4 nm 3H-IMI resulted in a concentration-dependent inhibition of 3H-IMI binding, w...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(86)90261-1
更新日期:1986-08-01 00:00:00
abstract::Despite the proven efficacy of acetylcholinesterase inhibitors in Alzheimer's disease, there is a need for new and more effective treatments. Galantamine is a novel treatment for Alzheimer's disease that inhibits acetylcholinesterase and modulates nicotinic receptors. In randomized, double-blind, placebo-controlled st...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(00)01101-x
更新日期:2001-02-01 00:00:00
abstract::The prevalence and role of sleep disorders in the sexual problems of diabetic patients remain unexplored. This study was conducted on 40 diabetic men carefully screened to exclude the confounding effects of other medical illnesses or drugs likely to impair sexual function and 40 age-matched healthy volunteers. They un...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(93)90388-t
更新日期:1993-08-01 00:00:00
abstract::Advances in the understanding of the neurobiology of fear extinction have resulted in the development of d-cycloserine (DCS), a partial glutamatergic N-methyl-D-aspartate agonist, as an augmentation strategy for exposure treatment. We review a decade of research that has focused on the efficacy of DCS for augmenting t...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2015.09.007
更新日期:2016-08-15 00:00:00
abstract:BACKGROUND:Depression is a heterogeneous mental illness. Neurostimulation treatments, by targeting specific nodes within the brain's emotion-regulation network, may be useful both as therapies and as probes for identifying clinically relevant depression subtypes. METHODS:Here, we applied 20 sessions of magnetic resona...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2013.10.026
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Frequent electroencephalographic arousals or awakenings associated with periodic leg movements (PLM) might be responsible in part for the complaints of sleep disturbances made by patients treated with antidepressants. Past studies, however, have determined the effects of only certain limited antidepressants,...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/j.biopsych.2005.04.022
更新日期:2005-09-15 00:00:00
abstract::Adrenocorticosteroids and serotonergic neurons exert reciprocal regulatory actions, and both are abnormal in depression. We evaluated whether glucocorticoids influence the serotonin transporter in rat platelets and brain by infusing dexamethasone for 26 days, sufficient for replacement of the entire platelet populatio...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(95)00469-6
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Chronic but not acute treatment with antidepressants increases hippocampal neurogenesis. Because chronic treatment with antidepressants also upregulates p11, we hypothesized that p11 might regulate effects of antidepressants on aspects of neurogenesis. METHODS:Fluoxetine was administered chronically to wild...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2010.01.024
更新日期:2010-06-01 00:00:00
abstract::Absence of skin conductance response (SCR) and failure of its habituation are psychophysiological signs observed in most schizophrenics. In the present experiments, skin conductance activity was studied in rats before and after intraventricular administration of 6-hydroxydopa (6-OHdopa), a neurotoxin that selectively ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(91)90222-8
更新日期:1991-02-15 00:00:00
abstract::Serotonin (5-HT) is an important regulator of morphogenetic activities during early central nervous system development, including cell proliferation, migration, and differentiation. The 5-HT transporter (5-HTT) plays a pivotal role in brain 5-HT homeostasis. It is also the initial target for both antidepressant drugs ...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(98)00121-8
更新日期:1998-08-01 00:00:00
abstract::This study investigates the relationship between depression and both anatomic and cerebral blood flow abnormalities in multiple sclerosis (MS) patients. Ten nondepressed MS patients were compared with 10 depressed MS patients matched for age, sex, and functional disability. Both groups were evaluated by means of neuro...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/0006-3223(95)00291-x
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:Eye movement desensitization and reprocessing (EMDR) is an effective treatment for posttraumatic stress disorder. During EMDR, patients make horizontal eye movements (EMs) while simultaneously recalling a traumatic memory, which renders the memory less vivid and emotional when it is later recalled again. Rec...
journal_title:Biological psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.biopsych.2017.03.012
更新日期:2017-10-15 00:00:00
abstract:BACKGROUND:The cardiovascular safety of mixed amphetamine salts extended release (MAS XR) was evaluated in 2968 children 6-12 years of age with attention-deficit/hyperactivity disorder (ADHD). METHODS:In this prospective, open-label, noncomparative, community-based study, subjects whose symptoms of ADHD were well cont...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2006.05.002
更新日期:2007-03-01 00:00:00
abstract::To confirm and extend previous observations concerning the correlation between cell-mediated immunity and psychiatric diseases, 511 patients with schizophrenia, cerebral atrophy, dementia, and mental retardation, and 32 control subjects and 27 control patients were skin-tested with human brain S-100 protein and human ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:Our previous work has shown genetic variation in the human choline transporter gene (CHT1) to be associated with depressive symptoms and autonomic cardiac (cholinergic) dysregulation. Here, functional magnetic resonance imaging (fMRI) was used to examine the relation between a single nucleotide polymorphism ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2006.03.059
更新日期:2006-11-15 00:00:00
abstract::This study evaluated the effect of an acute reduction in catecholamine synthesis produced by alpha-methyl-para-tyrosine (AMPT), a tyrosine hydroxylase inhibitor, on cocaine-induced euphoria. In a blinded, placebo-controlled study, AMPT (1 g p.o. T.I.D.) was given to 10 non-treatment-seeking cocaine abusers prior to in...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0006-3223(96)00331-9
更新日期:1997-08-01 00:00:00
abstract::The possibility of characterizing subgroups of depressive disorders by biological markers was studied by means of the dexamethasone suppression test (DST), the 24-hr urinary free cortisol (UFC), the growth hormone response to the insulin tolerance test (ITT), and polygraphic sleep recordings. Forty-five hospitalized p...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1982-11-01 00:00:00
abstract:BACKGROUND:Autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD) are associated with complex changes as revealed by functional magnetic resonance imaging. To date, neuroimaging-based models are not able to characterize individuals with sufficient sensitivity and specificity. Further, although evi...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2019.02.019
更新日期:2019-08-15 00:00:00