Abstract：
:Mood disorders are serious diseases that affect a large portion of the population. There have been many hypotheses put forth over the years to explain the development of major depression, bipolar disorder, and other mood disorders. These hypotheses include disruptions in monoamine transmission, hypothalamus-pituitary-adrenal axis function, immune function, neurogenesis, mitochondrial dysfunction, and neuropeptide signaling (to name a few). Nearly all people suffering from mood disorders have significant disruptions in circadian rhythms and the sleep/wake cycle. In fact, altered sleep patterns are one of the major diagnostic criteria for these disorders. Moreover, environmental disruptions to circadian rhythms, including shift work, travel across time zones, and irregular social schedules, tend to precipitate or exacerbate mood-related episodes. Recent studies have found that molecular clocks are found throughout the brain and body where they participate in the regulation of most physiological processes, including those thought to be involved in mood regulation. This review will summarize recent data that implicate the circadian system as a vital regulator of a variety of systems that are thought to play a role in the development of mood disorders.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
McClung CAdoi
10.1016/j.biopsych.2013.02.019subject
Has Abstractpub_date
2013-08-15 00:00:00pages
242-9issue
4eissn
0006-3223issn
1873-2402pii
S0006-3223(13)00187-Xjournal_volume
74pub_type
杂志文章,评审abstract：BACKGROUND:Recently, it has been reported that serum interleukin-1 beta (IL-1 beta), but not soluble IL-2 receptor (sIL-2R), concentrations were significantly higher in patients with posttraumatic stress disorder (PTSD) than in normal volunteers, and that psychological stress in humans is associated with increased secr...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(98)00131-0
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:Ovarian steroids modulate anxiety behavior, perhaps by regulating the serotonergic neurons in the midbrain raphe nucleus. The regulation of the brain-specific isoform of rat tryptophan hydroxylase (TPH2) by ovarian hormones has not yet been investigated. Therefore, we examined the effects of estrogen and pro...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2005.10.019
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:Elderly depressed patients have more vascular hyperintensities in frontal white matter and basal ganglia than elderly control subjects. Cell pathology that might be related to increased vascular hyperintensities has not been examined. METHODS:Postmortem samples from the orbitofrontal cortex (ORB) were colle...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2005.04.013
更新日期：2005-08-15 00:00:00
abstract：:In an investigation of biological indicators of stress in normal humans, undergraduate psychology students were differentiated on trait anxiety and assessed under baseline, preexam (stress), and postexam conditions. Assessment at each condition involved drawing 20 ml of blood, followed by self-reporting for selected q...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(85)90209-4
更新日期：1985-08-01 00:00:00
abstract：:Psychological functions that are behaviorally and neurally well specified may serve as endophenotypes for attention-deficit/hyperactivity disorder (ADHD) research. Such endophenotypes, which lie between genes and symptoms, may relate more directly to relevant genetic variability than does the clinical ADHD syndrome it...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2004.10.026
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:Men and women differ in their ability to extinguish fear. Fear extinction requires the activation of brain regions, including the ventromedial prefrontal cortex (vmPFC) and amygdala. Could estradiol modulate the activity of these brain regions during fear extinction? METHODS:All rat experiments were conduct...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2011.05.016
更新日期：2011-11-15 00:00:00
abstract：BACKGROUND:Several lines of evidence support the possibility that disturbances of dopamine (DA) function could contribute to alterations of weight, feeding, motor activity, and reward in anorexia nervosa (AN). METHODS:To assess possibly trait-related disturbances but avoid confounding effects of malnutrition, 10 women...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/j.biopsych.2005.05.003
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:QTc interval prolongation can occur as a result of treatment with both conventional and novel antipsychotic medications and is of clinical concern because of its association with the potentially fatal ventricular arrhythmia, torsade de pointes. METHODS:One case is described in which a patient with schizophr...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(01)01333-6
更新日期：2002-02-01 00:00:00
abstract：:Twenty-three inpatients who met DSM-III criteria for schizophrenia were selected for cerebrospinal fluid (CSF) neurochemical study of tardive dyskinesia (TD). Ten inpatients had tardive dyskinesia, and the remaining 13 patients without TD served as controls. There were no intergroup differences in sex, age, duration o...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(89)90243-6
更新日期：1989-03-15 00:00:00
abstract：:The addition of lithium to perphenazine altered the pattern of plasma homovanillic acid (HVA) during the course of treatment for acute psychosis. In the perphenazine-treated group plasma HVA declined significantly by days 7-9 of treatment, whereas in the perphenazine-plus-lithium group plasma HVA tended to increase. T...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(92)90190-b
更新日期：1992-12-15 00:00:00
abstract：BACKGROUND:Although genetic risk factors for posttraumatic stress disorder (PTSD) in similarly traumatized cohorts can be confounded with risk for type of exposure, the primary risk for exposure to the 9/11 attack on New York City was proximity, allowing study of PTSD risk in a sample that is not confounded by exposure...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.02.034
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:Microtubule-associated protein 2 (MAP2) is a neuronal protein that plays a role in maintaining dendritic structure through its interaction with microtubules. In schizophrenia (Sz), numerous studies have revealed that the typically robust immunoreactivity (IR) of MAP2 is significantly reduced across several c...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2014.12.029
更新日期：2015-09-15 00:00:00
abstract：BACKGROUND:The 5HTTLPR genetic variant of the serotonin transporter (SERT), which consists of a long (SERT-l) and short (SERT-s) allele, has emerged as a major factor influencing emotional behavior and brain anatomy. The pulvinar nucleus of the thalamus projects to important limbic nuclei including the amygdala and cin...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.08.047
更新日期：2007-03-15 00:00:00
abstract：BACKGROUND:The amplitude of the auditory P3 event-related potential is reduced in patients with axes I and II disorders. Data regarding P3 amplitude and normal personality traits in healthy individuals have been inconsistent, however, although more extreme variants of dimensional traits such as neuroticism and extraver...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(00)01067-2
更新日期：2001-06-01 00:00:00
abstract：:The interaction between various neuroleptics and antiparkinsonian drugs was analyzed by measuring the neuroleptic plasma level before and after withdrawal of antiparkinsonian drugs. The population completing the study consisted of 32 chronic schizophrenics treated with chlorpromazine (8), levomepromazine (14), thiorid...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1977-06-01 00:00:00
abstract：:The prevalence and role of sleep disorders in the sexual problems of diabetic patients remain unexplored. This study was conducted on 40 diabetic men carefully screened to exclude the confounding effects of other medical illnesses or drugs likely to impair sexual function and 40 age-matched healthy volunteers. They un...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(93)90388-t
更新日期：1993-08-01 00:00:00
abstract：:Performance on tasks tapping automatic and voluntary aspects of memory, attention, and motor speed was examined in 14 patients with major depressive disorder, before and after 3 weeks of treatment with clomipramine (150 mg/day), a potent serotonin and noradrenaline uptake blocker with anticholinergic side effects. Per...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90179-p
更新日期：1991-12-01 00:00:00
abstract：:Traumatic events are common, but posttraumatic stress disorder (PTSD) is relatively rare. These facts have prompted several questions: What variables increase risk for PTSD among trauma-exposed people? Can we distinguish between pathologic and nonpathologic responses to traumatic stressors? If so, what psychobiologica...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(02)01663-3
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND:Animal and human newborn studies suggest that exposure to cocaine in utero delays glial maturation and white matter myelination. Postmortem data show that in the frontal and temporal lobes, white matter myelination continues into middle age. Recent magnetic resonance imaging (MRI) data have confirmed continu...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(02)01315-x
更新日期：2002-04-15 00:00:00
abstract：:Thyrotropin-releasing hormone (TRH) has been reported to stimulate growth hormone (GH) release in a variety of pathological conditions, including some studies of major depression. Because of the considerable phenomenological and neuroendocrine overlap between major depression and panic disorder, we investigated the ra...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(90)90420-7
更新日期：1990-06-01 00:00:00
abstract：:Our previous studies have shown that in psychotics, the plasma serine level is abnormally high and that plasma serine hydroxymethyltransferase (which cleaves serine to glycine) activity is abnormally low as compared with that in nonpsychotic subjects. In this study, psychotic and nonpsychotic subjects ingested a large...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(85)90133-7
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:The demands of the Wisconsin Card Sorting Test (WCST) change with experience. This report contains two studies designed to examine N-methyl-D-aspartate (NMDA) receptor contributions to the executive components of WCST performance. These aspects of WCST performance figure more prominently in the initial compl...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(99)00097-9
更新日期：2000-01-15 00:00:00
abstract：:Stable schizophrenic and schizoaffective outpatients underwent abrupt withdrawal from a fixed dose of neuroleptic. Prolactin concentrations were determined preceding and following drug withdrawal. Basal prolactin concentrations were significantly lower 3, 4, or 5 days following drug withdrawal than on subsequent days....
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(89)90016-4
更新日期：1989-06-01 00:00:00
abstract：BACKGROUND:The magnitude of the startle eyeblink response is reduced if the startle eliciting stimulus is shortly preceded by another stimulus. There is evidence that schizophrenia patients exhibit impairments in this so-called prepulse inhibition. Our study investigated whether prepulse inhibition is affected by neuro...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(99)00229-2
更新日期：2000-01-01 00:00:00
abstract：:Previous studies have shown an association between low serum cholesterol concentration and suicide; however, conflicting results have also been reported. To examine this potential association, cholesterol levels in 99 patients admitted to an emergency ward following an attempted suicide were compared with those in 74 ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/S0006-3223(95)00672-9
更新日期：1997-01-15 00:00:00
abstract：:In a sample of 13 endogenous depressive inpatients, REM (rapid eye movement) latency (recorded over 4 consecutive nights after 2 habituation nights) and contingent negative variation amplitude showed significant relationship, suggesting that both parameters may depend on the same mechanisms, possibly cholinergic. ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(85)90115-5
更新日期：1985-12-01 00:00:00
abstract：:It has been generally accepted that increased thyroid function facilitates treatment response in depression. Recent data show that response to several antidepressant treatments, particularly lithium and carbamazepine, are associated with decreased thyroid hormone levels. An alternative hypothesis that decreased thyroi...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：BACKGROUND:Clinical reports suggest that rather than directly driving cocaine use, stress may create a biological context within which other triggers for drug use become more potent. We hypothesize that stress-induced increases in corticosterone "set the stage" for relapse by promoting endocannabinoid-induced attenuati...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2017.09.024
更新日期：2018-07-15 00:00:00
abstract：BACKGROUND:DISC1 has been suggested as a causative gene for psychoses in a large Scottish kindred. PCNT2 has recently been identified as an interacting partner of DISC1. In this study, we investigated the role of PCNT2 in bipolar disorder, by gene expression analysis and genetic association study. METHODS:By TaqMan re...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.07.010
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:The cAMP signaling pathway, and its downstream neurotrophic factor BDNF, are major targets of antidepressant medications. Abnormalities in this pathway have previously been reported in postmortem brain of subjects with mood disorders. This study was designed to test whether the diagnosis of a mood disorder, ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(01)01083-6
更新日期：2001-08-15 00:00:00
