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Effect of neuroleptic withdrawal on plasma prolactin: a possible marker of receptor adaptation.

Abstract：

:Stable schizophrenic and schizoaffective outpatients underwent abrupt withdrawal from a fixed dose of neuroleptic. Prolactin concentrations were determined preceding and following drug withdrawal. Basal prolactin concentrations were significantly lower 3, 4, or 5 days following drug withdrawal than on subsequent days. This rebound effect may be related to dopaminergic receptor changes in the tuberoinfundibular system that are induced by chronic neuroleptic administration.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Kirkpatrick B,Buchanan RW,Maeda K,Carpenter WT Jr,Jauch D,Tamminga CA

doi

10.1016/0006-3223(89)90016-4

subject

Has Abstract

pub_date

1989-06-01 00:00:00

pages

131-8

issue

2

eissn

0006-3223

issn

1873-2402

pii

0006-3223(89)90016-4

journal_volume

26

pub_type

杂志文章

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