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Platelet alpha-2-adrenergic dysfunction in negative symptom schizophrenia: a preliminary study.

Abstract：

:The specific binding to platelet membranes (Bmax) of 3H-clonidine, an alpha-2 agonist, and 3H-yohimbine, an alpha-2 antagonist, was measured in nine drug-free male schizophrenic patients and repeated after 2 weeks of chlorpromazine (CPZ) treatment. Patients with a lower pretreatment Bmax for 3H-clonidine showed a significantly smaller change in Bmax after treatment, less improvement in their clinical state, as indicated by the change in the Global Assessment Scale (GAS), and a lower posttreatment GAS. Also, they had a significantly higher score for negative symptoms on the Affect Rating Scale both before and after treatment. These findings suggest that schizophrenic patients with relatively subsensitive platelet alpha-2-adrenergic receptors, as measured by 3H-clonidine binding, tend to have more negative symptoms and a diminished alpha receptor binding response and diminished clinical response to CPZ. There were no clinical correlations to 3H-yohimbine binding.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Rosen J,Silk KR,Rice HE,Smith CB

doi

10.1016/0006-3223(85)90025-3

subject

Has Abstract

pub_date

1985-05-01 00:00:00

pages

539-45

issue

5

eissn

0006-3223

issn

1873-2402

pii

0006-3223(85)90025-3

journal_volume

20

pub_type

杂志文章

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