Abstract:
:Altered bioavailability or altered pharmacokinetics of dexamethasone (dex) may contribute to a positive Dexamethasone Suppression Test (DST) in psychiatric patients. We measured plasma dex and plasma cortisol concentrations in 32 patients with primary major depressive disorder (MDD), 14 patients with other psychiatric disorders, and 16 normal controls. Cortisol was measured by the competitive protein binding (CPB) assay and dex by RIA (IgG Corp.). Additionally, cortisol was measured by a fluorescent polarization immunoassay (FPIA) available on the Abbott TDx analyzer in an attempt to validate this method for use in the DST. The agreement between FPIA and CPB cortisol results was excellent. Depressed nonsuppressors, by definition, had significantly higher mean plasma cortisol concentrations than depressed suppressors, psychiatric controls, and normal volunteers at 8:00 AM, 3:00 PM, and 10:00 PM postdex. When DST nonsuppressors and suppressors were compared regardless of diagnostic group, plasma dex concentrations were significantly lower (p less than 0.01) in the DST nonsuppressors. There was a significant negative correlation between plasma cortisol levels and plasma dex levels across all subjects at 8:00 AM (r = -0.365, n = 44, p less than 0.05). When the subjects were sorted by diagnostic category, there was a strong, but not statistically significant, trend toward lower plasma dex concentrations in the melancholic nonsuppressors versus the melancholic suppressors and between the psychiatric control non-suppressors and the corresponding suppressor group. These relationships disappeared when we restricted our analyses to an empirically derived middle range of plasma dex concentrations within which the DST results were considered to be valid. We conclude that bioavailability or pharmacokinetics of dex may significantly contribute to DST results. Further investigation is needed to determine whether or not the quantification of dex and its metabolites and their determination at which specific timepoints during the DST will enhance the predictive or interpretive value of the DST in psychiatric patients.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Ritchie JC,Belkin BM,Krishnan KR,Nemeroff CB,Carroll BJdoi
10.1016/0006-3223(90)90646-jsubject
Has Abstractpub_date
1990-01-15 00:00:00pages
159-73issue
2eissn
0006-3223issn
1873-2402pii
0006-3223(90)90646-Jjournal_volume
27pub_type
杂志文章abstract:BACKGROUND:Prior investigations of cross-informant agreement among parents, teachers, and clinicians about externalizing and internalizing problems have not directly addressed agreement about manic symptoms. METHODS:We identified three groups from a large cohort of youths, aged 8-12 years, treated on an inpatient unit...
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-05-15 00:00:00
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更新日期:2019-02-15 00:00:00
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doi:10.1016/j.biopsych.2007.11.009
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2018.09.026
更新日期:2019-03-15 00:00:00
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更新日期:2002-09-15 00:00:00
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journal_title:Biological psychiatry
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更新日期:2019-10-15 00:00:00
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doi:10.1016/s0006-3223(03)00073-8
更新日期:2003-10-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1984-07-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1998-02-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2009.01.009
更新日期:2009-05-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/0006-3223(93)90087-t
更新日期:1993-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0006-3223(98)00234-0
更新日期:1999-06-01 00:00:00
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更新日期:1990-05-01 00:00:00
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更新日期:2006-04-01 00:00:00
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doi:10.1016/s0006-3223(99)00004-9
更新日期:1999-09-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.biopsych.2013.10.009
更新日期:2014-08-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-05-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2002-09-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,meta分析
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更新日期:2007-04-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章
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