Neuroendocrine response to antipsychotics: effects of drug type and gender.

abstract：BACKGROUND:In the Systematic Treatment Enhancement Program for Bipolar Disorder, we showed that valproate is associated with new-onset menstrual-cycle irregularities and hyperandrogenism in 10.5% of 86 women. We now determine whether polycystic ovarian syndrome (PCOS) features reverse on valproate discontinutation. ME...

journal_title：Biological psychiatry

authors： Joffe H,Cohen LS,Suppes T,Hwang CH,Molay F,Adams JM,Sachs GS,Hall JE

更新日期：2006-12-15 00:00:00

abstract：BACKGROUND:Major depressive disorder (MDD) is a moderately heritable disorder with a high lifetime prevalence. At present, laboratory blood tests to support MDD diagnosis are not available. METHODS:We used a classifier approach on blood gene expression profiles of a unique set of unmedicated subjects (MDD patients and...

journal_title：Biological psychiatry

authors： Spijker S,Van Zanten JS,De Jong S,Penninx BW,van Dyck R,Zitman FG,Smit JH,Ylstra B,Smit AB,Hoogendijk WJ

更新日期：2010-07-15 00:00:00

abstract：:Auditory evoked potentials were recorded using a paired click, conditioning-testing paradigm in 10 schizophrenics and in 10 normal subjects with no family history of psychotic disorder. The paradigm is used to demonstrate central nervous system gating of responsiveness to auditory stimuli by examining the extent to wh...

journal_title：Biological psychiatry

authors： Nagamoto HT,Adler LE,Waldo MC,Freedman R

更新日期：1989-03-01 00:00:00

abstract：:Both genetic and environmental factors have been associated with an increased risk for schizophrenia. These factors are not mutually exclusive; a single gene can be a genetic factor (due to a mutation in the gene sequence) and a target of a physiological response to an environmental stimulus, both with the common endp...

journal_title：Biological psychiatry

authors： Levitt P,Ebert P,Mirnics K,Nimgaonkar VL,Lewis DA

更新日期：2006-09-15 00:00:00

abstract：:Postmortem volumetry of cortex, white matter, and basal ganglia was performed in 23 brains of schizophrenic patients and 23 brains of controls closely matched for gender, age, and hemisphere. Stereological methods were applied to serial coronal sections of complete hemispheres. We found no significant volume changes o...

journal_title：Biological psychiatry

authors： Heckers S,Heinsen H,Heinsen Y,Beckmann H

更新日期：1991-03-15 00:00:00

abstract：BACKGROUND:Association analysis identified the homeobox transcription factor, ENGRAILED 2 (EN2), as a possible autism spectrum disorder (ASD) susceptibility gene (ASD [MIM 608636]; EN2 [MIM 131310]). The common alleles (underlined) of two intronic single nucleotide polymorphisms (SNPs), rs1861972 (A/G) and rs1861973 (C...

journal_title：Biological psychiatry

authors： Benayed R,Choi J,Matteson PG,Gharani N,Kamdar S,Brzustowicz LM,Millonig JH

更新日期：2009-11-15 00:00:00

abstract：:In a neuroendocrine challenge paradigm, the present study investigated responses of schizophrenic patients to m-chlorophenylpiperazine (MCPP), a serotonin (5-hydroxytryptamine, 5HT) agonist. In an oral dose of 0.25 mg/kg, MCPP was administered in a placebo-controlled double-blind design to male schizophrenic patients ...

journal_title：Biological psychiatry

authors： Iqbal N,Asnis GM,Wetzler S,Kahn RS,Kay SR,van Praag HM

更新日期：1991-10-15 00:00:00

abstract：BACKGROUND:Investigators have reported lack of normal asymmetry of lateralization in some schizophrenic patients, as measured postmortem and by preference and/or performance. It has been suggested that this lack of asymmetry is related to early onset of schizophrenia. The present study extends the inquiry by magnetic r...

journal_title：Biological psychiatry

authors： Maher BA,Manschreck TC,Yurgelun-Todd DA,Tsuang MT

更新日期：1998-09-15 00:00:00

abstract：:The behavioral effects of a 2 mg/kg iv bolus infusion of naloxone were compared with a placebo infusion using a double-blind design in a small group of inpatient depressives (n = 6) and normals (n = 8). Naloxone produced consistent and significant worsening in the rated signs and subjective symptoms of depression in t...

journal_title：Biological psychiatry

authors： Cohen MR,Cohen RM,Pickar D,Sunderland T,Mueller EA 3rd,Murphy DL

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:Plasma homovanillic acid (HVA) changes in response to a challenge of several days with haloperidol have been found to be predictive of the therapeutic response to haloperidol over a longer period of treatment. METHODS:Twenty-six elderly women who gave informed consent were divided into two groups, with or w...

journal_title：Biological psychiatry

authors： Andia I,Zumarraga M,Zabalo MJ,Bulbena A,Davila R

更新日期：1998-01-01 00:00:00

abstract：:The acoustic startle response (ASR) and midlatency auditory evoked potentials (AEP) have been utilized in the measurement of sensory inhibition. Using these different paradigms, abnormalities suggesting a lack of normal inhibition have been noted in a number of psychiatric syndromes. To date, the most commonly used se...

journal_title：Biological psychiatry

authors： Schwarzkopf SB,Lamberti JS,Smith DA

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Despite cognitive function impairment in depression, its relationship to treatment outcome is not well understood. Here, we examined whether pretreatment activation of cortical circuitry during test of cognitive functions predicts outcomes for three commonly used antidepressants. METHODS:Eighty medication-f...

journal_title：Biological psychiatry

authors： Gyurak A,Patenaude B,Korgaonkar MS,Grieve SM,Williams LM,Etkin A

更新日期：2016-02-15 00:00:00

abstract：:As many patients still require maintenance neuroleptic medication, it is important to determine what factors affect the course of tardive dyskinesia (TD) during ongoing neuroleptic treatment. In this study the data are from a series of annual examinations using the Abnormal Involuntary Movement Scale (AIMS) in a cohor...

journal_title：Biological psychiatry

authors： Bergen J,Kitchin R,Berry G

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Numerous studies have implicated neurogenesis in the hippocampus in animal models of depression, especially those related to controllability and learned helplessness. Here, we tested the hypothesis that uncontrollable but not controllable stress would reduce cell proliferation in the hippocampus of male and ...

journal_title：Biological psychiatry

authors： Shors TJ,Mathew J,Sisti HM,Edgecomb C,Beckoff S,Dalla C

更新日期：2007-09-01 00:00:00

abstract：:Reduced platelet MAO activity has been previously reported as a biochemical marker for a subgroup of psychiatric patients, including some chronic schizophrenics. As tryptamine metabolism appears to be sensitive to alterations in MAO activity, urinary tryptamine excretion was measured in chronic schizophrenics with low...

journal_title：Biological psychiatry

authors： Sullivan JL,Coffey CE,Basuk B,Cavenar JO,Maltbie AA,Zung WW

更新日期：1980-02-01 00:00:00

abstract：BACKGROUND:Neurocognitive deficits are recognized as a cardinal feature of schizophrenia, but the determinants of these deficits remain unknown. Recent reports have suggested that a functional polymorphism, Val(158)Met in exon III of the catechol-O-methyltransferase gene, shares approximately 4% variance with performan...

journal_title：Biological psychiatry

authors： Bilder RM,Volavka J,Czobor P,Malhotra AK,Kennedy JL,Ni X,Goldman RS,Hoptman MJ,Sheitman B,Lindenmayer JP,Citrome L,McEvoy JP,Kunz M,Chakos M,Cooper TB,Lieberman JA

更新日期：2002-10-01 00:00:00

abstract：:The evidence that catecholestrogens are formed in the brain and exert behavioral effects in animal models suggest that these steroids might have psychotropic activities. In the present investigation, the formation and metabolism of catecholestrogens were studied in depressed patients. Twenty-four-hr urine samples were...

journal_title：Biological psychiatry

authors： Banger M,Hiemke C,Knuppen R,Ball P,Haupt M,Wiedemann K

更新日期：1990-10-15 00:00:00

abstract：BACKGROUND:The stomach-derived hormone ghrelin drives higher-order feeding processes related to food reward and food seeking via central nervous system signaling at its receptor (GHSR1A). The specific nuclei mediating these effects are only partially understood. Here, we use a rat model to examine whether ghrelin signa...

journal_title：Biological psychiatry

authors： Kanoski SE,Fortin SM,Ricks KM,Grill HJ

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Converging evidence has demonstrated an association between the Disrupted in Schizophrenia 1 (DISC1) gene and schizophrenia (SZ). Within the DISC1 gene, a single nucleotide polymorphism (SNP), Ser704Cys, has been associated with the structure and function of the hippocampus. Because positive symptoms in SZ h...

journal_title：Biological psychiatry

authors： DeRosse P,Hodgkinson CA,Lencz T,Burdick KE,Kane JM,Goldman D,Malhotra AK

更新日期：2007-05-15 00:00:00

abstract：:The addition of lithium to perphenazine altered the pattern of plasma homovanillic acid (HVA) during the course of treatment for acute psychosis. In the perphenazine-treated group plasma HVA declined significantly by days 7-9 of treatment, whereas in the perphenazine-plus-lithium group plasma HVA tended to increase. T...

journal_title：Biological psychiatry

authors： Bowers MB Jr,Mazure CM,Nelson JC,Jatlow PI

更新日期：1992-12-15 00:00:00

abstract：:Urinary MHPG concentrations and platelet 3H-imipramine binding (Bmax, Kd) were measured in 20 psychiatric inpatients with diagnoses of major depressive disorder. Clinical assessments were performed using the Present State Examination (PSE) interview, and several dimensions of symptomatology were constructed on the bas...

journal_title：Biological psychiatry

authors： Carr V,Edwards J,Prior M

更新日期：1988-03-15 00:00:00

abstract：:Prominent heightened arousal symptoms and clinical/laboratory findings implicate the central noradrenergic system in posttraumatic stress disorder (PTSD). Heightened arousal frequently manifests in relation to sleep in PTSD. Central noradrenergic systems have a role in regulating arousal levels during sleep. We theref...

journal_title：Biological psychiatry

authors： Mellman TA,Kumar A,Kulick-Bell R,Kumar M,Nolan B

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Inositol has been reported to be an effective treatment in depression, and we hypothesized that inositol addition might enhance or speed up response to serotonin selective reuptake inhibitors (SSRI). METHODS:Twenty-seven depressed patients completed a double-blind controlled 4-week trial of SSRI plus placeb...

journal_title：Biological psychiatry

authors： Levine J,Mishori A,Susnosky M,Martin M,Belmaker RH

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Acute ketamine has been shown to model features of schizophrenia such as psychotic symptoms, cognitive deficits and smooth pursuit eye movement dysfunction. There have been suggestions that chronic ketamine may also produce an analogue of the disorder. In this study, we investigated the effect of persistent ...

journal_title：Biological psychiatry

authors： Morgan CJ,Huddy V,Lipton M,Curran HV,Joyce EM

更新日期：2009-06-15 00:00:00

abstract：:Despite recognition that schizophrenia must have syndrome status in the absence of proof of a single etiopathophysiologic process, a century of work has been based on designs that conceptualize schizophrenia as a single disease entity. Reducing heterogeneity at several levels of functioning is desirable. In this artic...

journal_title：Biological psychiatry

authors： Carpenter WT Jr,Arango C,Buchanan RW,Kirkpatrick B

更新日期：1999-08-01 00:00:00

abstract：:The validity of previously hypothesized predictors of elapse following neuroleptic discontinuation was examined. One hundred sixty-two outpatients, with either Research Diagnostic Criteria schizophrenia or schizoaffective disorder, were discontinued from neuroleptic medication for a 28-day period or until judged to be...

journal_title：Biological psychiatry

authors： Buchanan RW,Kirkpatrick B,Summerfelt A,Hanlon TE,Levine J,Carpenter WT Jr

更新日期：1992-07-01 00:00:00

abstract：:Cannabis use has been reported to increase the risk of developing schizophrenia and to worsen symptoms of the illness. Both of these outcomes might be attributable to the disruption by cannabis of the endogenous cannabinoid system's spatiotemporal regulation of the inhibitory circuitry in the prefrontal cortex that is...

journal_title：Biological psychiatry

authors： Volk DW,Lewis DA

更新日期：2016-04-01 00:00:00

abstract：:There are very few reports about asterixis as a side effect of treatment with psychopharmacologic agents. In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its...

journal_title：Biological psychiatry

authors： Rittmannsberger H,Leblhuber F

更新日期：1992-08-15 00:00:00

abstract：BACKGROUND:There is a paucity of neuroimaging data in pediatric-onset obsessive-compulsive disorder (OCD). This multimodal neuroimaging study aimed to identify structural gray (GM) and white matter (WM) microstructure changes in pediatric OCD. METHODS:We obtained structural and diffusion tensor magnetic resonance imag...

journal_title：Biological psychiatry

authors： Zarei M,Mataix-Cols D,Heyman I,Hough M,Doherty J,Burge L,Winmill L,Nijhawan S,Matthews PM,James A

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Chronic treatment of rats with certain selective serotonin or norepinephrine reuptake inhibitors produces significant decreases, respectively, in serotonin and norepinephrine transporter binding sites in brain. Duloxetine may be a dual serotonin/norepinephrine reuptake inhibitor, as it is only a slightly mor...

journal_title：Biological psychiatry

authors： Gould GG,Javors MA,Frazer A

更新日期：2007-01-15 00:00:00