Abstract：
:The evidence that catecholestrogens are formed in the brain and exert behavioral effects in animal models suggest that these steroids might have psychotropic activities. In the present investigation, the formation and metabolism of catecholestrogens were studied in depressed patients. Twenty-four-hr urine samples were collected from 6 male patients (59 +/- 8 years) with endogenous retarded depression (subtype primary, endogenous, and recurrent according to Research Diagnostic Criteria) and from 12 male control subjects (51 +/- 4 years). The patients were treated with the monoamine oxidase inhibitor tranylcypromine (10-40 mg/day for 3-4 weeks). The concentrations of primary estrogens, 4- and 2-hydroxyestrogens and 2-methoxyestrogens, were measured in the urine samples after multiple chromatographic separation steps by radioimmunoassay. In the depressed patients, the excretion rates of 4-hydroxyestrogens were significantly lower than in control subjects. The ratio 2-methoxyestrogens:2-hydroxyestrogens as an index for 2-O-methylation was 3.8 +/- 1.6 in patients and 1.8 +/- 0.7 in controls. The increased methylation and reduced 4-hydroxylation rates of patients were not affected by treatment with tranylcypromine though the psychopathological state was improved by 46%. Therefore, it seemed unlikely that the observed alterations were pathognomonically relevant in these depressed patients. The alterations in the formation and methylation of catecholestrogens show that the depressed patients exhibited remarkable metabolic disturbances. The functional role of these disturbances remains to be clarified.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Banger M,Hiemke C,Knuppen R,Ball P,Haupt M,Wiedemann Kdoi
10.1016/0006-3223(90)90455-bsubject
Has Abstractpub_date
1990-10-15 00:00:00pages
685-96issue
8eissn
0006-3223issn
1873-2402pii
0006-3223(90)90455-Bjournal_volume
28pub_type
杂志文章abstract：BACKGROUND:Genetic studies of schizophrenia have implicated numerous risk loci including several copy number variants (CNVs) of large effect and hundreds of loci of small effect. In only a few cases has a specific gene been clearly identified. Rare CNVs affecting a single gene offer a potential avenue to discovering sc...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2019.09.023
更新日期：2020-04-15 00:00:00
abstract：:Psychiatric and neurologic disorders ranging from mental retardation to addiction are accompanied by structural and functional alterations of synaptic connections in the brain. Such alterations include abnormal density and morphology of dendritic spines, synapse loss, and aberrant synaptic signaling and plasticity. Re...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2003.10.006
更新日期：2004-06-15 00:00:00
abstract：BACKGROUND:A parallel downregulation of brain-derived neurotrophic factor (BDNF) and somatostatin (SST), a marker of inhibitory gamma-aminobutyric acid interneurons that target pyramidal cell dendrites, has been reported in several brain areas of subjects with major depressive disorder (MDD). Rodent genetic studies sug...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2018.09.026
更新日期：2019-03-15 00:00:00
abstract：BACKGROUND:Unipolar major depressive disorder (MDD) is characterized by anomalous neurobiological responses to pleasant stimuli, a pattern that may be linked to symptoms of anhedonia. However, the potential for psychotherapy to normalize neurobiological responses to pleasant stimuli has not been evaluated. METHODS:Twe...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.06.021
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:Traumatic experience can result in life-long changes in the ability to cope with future stressors and emotionally salient events. These experiences, particularly during early development, are a significant risk factor for later life anxiety disorders such as posttraumatic stress disorder (PTSD). However, bec...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2013.10.007
更新日期：2014-08-15 00:00:00
abstract：:The densities of platelet 3H-imipramine sites were determined by repetitive measures of 11 normal controls over the course of 1 year. A significant seasonal variation was found, with a circannual peak on February 17 and a nadir on August 18. The estimated amplitude of this rhythm was +/- 599.54 fmol/mg, which fluctuat...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(89)90069-3
更新日期：1989-09-01 00:00:00
abstract：BACKGROUND:Evidence suggests that the noradrenergic and corticotrophin-releasing factor (CRF) systems play critical roles in relapse and stress-related behaviors. In particular, behavioral studies point to a serial signaling process initiated by β-adrenergic receptors that requires CRF receptor (CRFR)-dependent signali...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.12.030
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:The interactions among experience, emotion, and memory are considered to be instrumental in the ontogeny and maintenance of acquired emotional and behavioral disorders (e.g., phobias). Here we address the question whether an anxiety-like state can associate with taste to produce conditioned taste aversion (C...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.08.024
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:Impaired neuromotor development is often one of the earliest observations in children with autism spectrum disorder (ASD). We investigated whether a genetic predisposition to developmental disorders was associated with nonoptimal neuromotor development during infancy and examined the genetic correlation betw...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2019.06.006
更新日期：2020-01-15 00:00:00
abstract：BACKGROUND:Acute ketamine has been shown to model features of schizophrenia such as psychotic symptoms, cognitive deficits and smooth pursuit eye movement dysfunction. There have been suggestions that chronic ketamine may also produce an analogue of the disorder. In this study, we investigated the effect of persistent ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.10.045
更新日期：2009-06-15 00:00:00
abstract：BACKGROUND:Variations in maternal care in the rat associate with robust differences in hippocampal development and synaptic plasticity in the offspring. Maternal care also influences pituitary-adrenal stress responses and corticosterone (CORT) regulation of hippocampal plasticity. N-methyl-D-aspartate receptors (NMDAR)...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.03.016
更新日期：2012-09-15 00:00:00
abstract：BACKGROUND:The ability to spontaneously attend to the social overtures and activities of others is essential for the development of social cognition and communication. This ability is critically impaired in toddlers with autism spectrum disorders (ASD); however, it is not clear if prodromal symptoms in this area are al...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.11.022
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:Many polymorphisms in dopamine genes are reported to affect cognitive, imaging, or clinical phenotypes. It is often inferred or assumed that such associations are causal, mediated by a direct effect of the polymorphism on the gene product itself. However, the supporting evidence is not always clear. METHODS...
journal_title：Biological psychiatry
pub_type： 杂志文章,meta分析
doi：10.1016/j.biopsych.2019.05.014
更新日期：2019-10-15 00:00:00
abstract：BACKGROUND:Identifying factors that modify responsiveness to pharmacotherapies for alcohol dependence is important for treatment planning. Cigarette smoking predicts more severe alcohol dependence and poorer treatment response in general. Nevertheless, there is limited research on cigarette smoking as a potential predi...
journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.biopsych.2012.03.023
更新日期：2012-11-15 00:00:00
abstract：BACKGROUND:The magnitude of the startle eyeblink response is reduced if the startle eliciting stimulus is shortly preceded by another stimulus. There is evidence that schizophrenia patients exhibit impairments in this so-called prepulse inhibition. Our study investigated whether prepulse inhibition is affected by neuro...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(99)00229-2
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Brain imaging and behavioral studies suggest an inverse relationship between dopamine (DA) D2/D3 receptors and vulnerability to cocaine abuse, although most research has used males. For example, male monkeys that become dominant in a social group have significant elevations in D2/D3 receptor availability and...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.03.002
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:GPR88 is an orphan G protein coupled receptor highly enriched in the striatum, and previous studies have focused on GPR88 function in striatal physiology. The receptor is also expressed in other brain areas, and here we examined whether GPR88 function extends beyond striatal-mediated responses. METHODS:We c...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2015.05.020
更新日期：2016-06-01 00:00:00
abstract：:Plasma norepinephrine (NE), free 3-methoxy-4-hydroxyphenethylene glycol (MHPG), and binding of tritiated yohimbine to platelet membranes were measured in 14 patients with generalized anxiety disorder (GAD), who were matched for age and sex with 14 patients with unipolar major depressive disorder (MDD) and 14 normal su...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(89)90158-3
更新日期：1989-01-15 00:00:00
abstract：BACKGROUND:Although genetic risk factors for posttraumatic stress disorder (PTSD) in similarly traumatized cohorts can be confounded with risk for type of exposure, the primary risk for exposure to the 9/11 attack on New York City was proximity, allowing study of PTSD risk in a sample that is not confounded by exposure...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.02.034
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:We examined the effect of prolonged methylphenidate (MPH) treatment on the functional neuroanatomy of executive functioning in adult men with attention-deficit/hyperactivity disorder (ADHD). METHODS:Positron emission tomography with [(15)O] water measured alterations of regional cerebral blood flow (rCBF) d...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/j.biopsych.2004.07.011
更新日期：2004-10-15 00:00:00
abstract：BACKGROUND:Current smoking cessation therapies offer limited success, as relapse rates remain high. Nicotine, which is the major component of tobacco smoke, is thought to be primarily responsible for the addictive properties of tobacco. However, little is known about the molecular mechanisms underlying nicotine relapse...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2014.02.001
更新日期：2014-11-01 00:00:00
abstract：:Proton spectra in the regions of the right and left basal ganglia were studied in 14 medicated patients with chronic schizophrenia using proton magnetic resonance spectroscopy (1H MRS). Ratios of N-acetyl-aspartate (NAA) to choline-containing compounds (Cho) were significantly reduced in the bilateral basal ganglia re...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(95)00316-9
更新日期：1996-07-01 00:00:00
abstract：:Association of the G72/G30 locus with schizophrenia and bipolar disorder has now been reported in several studies. The G72/G30 locus may be one of several that account for the evidence of linkage that spans a broad region of chromosome 13q. However, the story of G72/G30 is complex. Our meta-analysis of published assoc...
journal_title：Biological psychiatry
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.biopsych.2006.01.019
更新日期：2006-07-15 00:00:00
abstract：:Intracerebroventricular (icv) administration of corticotropin-releasing hormone (CRH) or exposure to a restraint stressor causes acute anorexia in rats. However, the effects on food intake of repeated injections of CRH or repeated exposures to restraint stress have not been previously reported. As the effects of these...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(90)90046-5
更新日期：1990-05-15 00:00:00
abstract：BACKGROUND:Despite widely replicated abnormalities of gamma-aminobutyric acid (GABA) neurons in schizophrenia postmortem, few studies have measured tissue GABA levels in vivo. We used proton magnetic resonance spectroscopy to measure tissue GABA levels in participants with schizophrenia and healthy control subjects in ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.05.016
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND:K-complexes (KCs) are evoked delta frequency electroencephalogram (EEG) responses during sleep that occur when large numbers of healthy cortical cells burst fire in a synchronized manner. The KC amplitude and incidence are sensitive measures of normal healthy brain aging. Given the known neurodegenerative co...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.10.010
更新日期：2009-07-15 00:00:00
abstract：:The validity of previously hypothesized predictors of elapse following neuroleptic discontinuation was examined. One hundred sixty-two outpatients, with either Research Diagnostic Criteria schizophrenia or schizoaffective disorder, were discontinued from neuroleptic medication for a 28-day period or until judged to be...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(92)90143-n
更新日期：1992-07-01 00:00:00
abstract：:Interpersonal factors play significant roles in the onset, maintenance, and remission of psychiatric conditions. In the current major diagnostic classification systems for psychiatric disorders, some conditions are defined by the presence of impairments in social interaction or maintaining interpersonal relationships;...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2012.03.033
更新日期：2012-07-15 00:00:00
abstract：:Converging lines of evidence suggest a role for the mesolimbic dopamine system in the response to somatic antidepressant therapies. Here, we review evidence suggesting that antidepressant treatments of different types share the effect of increasing the sensitivity of dopamine D2-like receptors in the nucleus accumbens...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2006.05.031
更新日期：2007-01-15 00:00:00
abstract：:This study is designed to measure effects of serotonin 1A (5-HT1A) agonists on escape deficits produced by inescapable shock in rats--a model of learned helplessness. Rats were first exposed to 60 inescapable shocks (15-sec duration, 0.8 mA, every 1 min +/- 15 sec), and 48 hr later, they were subjected to daily 15-min...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(88)90034-0
更新日期：1988-02-01 00:00:00
