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Deficit psychopathology and a paradigm shift in schizophrenia research.

Abstract：

:Despite recognition that schizophrenia must have syndrome status in the absence of proof of a single etiopathophysiologic process, a century of work has been based on designs that conceptualize schizophrenia as a single disease entity. Reducing heterogeneity at several levels of functioning is desirable. In this article we summarize progress using deficit syndrome psychopathology to address heterogeneity. The deficit syndrome has proven to be reliable, with construct validity, as well as predictive validity with biological, treatment, and course variables. We propose a shift in schizophrenia research away from the syndrome level toward study designs that identify more homogeneous entities. Doing so will increase the statistical power of study designs by reducing false positive cases.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Carpenter WT Jr,Arango C,Buchanan RW,Kirkpatrick B

doi

10.1016/s0006-3223(99)00088-8

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

352-60

issue

3

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(99)00088-8

journal_volume

46

pub_type

杂志文章,评审

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