Abstract：
BACKGROUND:A recent analysis of 25 historical candidate gene polymorphisms for schizophrenia in the largest genome-wide association study conducted to date suggested that these commonly studied variants were no more associated with the disorder than would be expected by chance. However, the same study identified other variants within those candidate genes that demonstrated genome-wide significant associations with schizophrenia. As such, it is possible that variants within historic schizophrenia candidate genes are associated with schizophrenia at levels above those expected by chance, even if the most-studied specific polymorphisms are not. METHODS:The present study used association statistics from the largest schizophrenia genome-wide association study conducted to date as input to a gene set analysis to investigate whether variants within schizophrenia candidate genes are enriched for association with schizophrenia. RESULTS:As a group, variants in the most-studied candidate genes were no more associated with schizophrenia than were variants in control sets of noncandidate genes. While a small subset of candidate genes did appear to be significantly associated with schizophrenia, these genes were not particularly noteworthy given the large number of more strongly associated noncandidate genes. CONCLUSIONS:The history of schizophrenia research should serve as a cautionary tale to candidate gene investigators examining other phenotypes: our findings indicate that the most investigated candidate gene hypotheses of schizophrenia are not well supported by genome-wide association studies, and it is likely that this will be the case for other complex traits as well.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Johnson EC,Border R,Melroy-Greif WE,de Leeuw CA,Ehringer MA,Keller MCdoi
10.1016/j.biopsych.2017.06.033subject
Has Abstractpub_date
2017-11-15 00:00:00pages
702-708issue
10eissn
0006-3223issn
1873-2402pii
S0006-3223(17)31772-9journal_volume
82pub_type
杂志文章abstract：:Acute Intermittent Porphyria (AIP) is an autosomal dominant metabolic disorder that has various psychiatric manifestations. This is a report of a case who had six brief psychotic episodes of varying nature within a 2-month period. The psychotic manifestations included catatonic stupor, hypomania, and delirium in diffe...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(94)90085-x
更新日期：1994-12-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2005-03-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/0006-3223(96)00029-7
更新日期：1996-10-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2014.09.004
更新日期：2015-05-15 00:00:00
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pub_type： 杂志文章,meta分析
doi：10.1016/j.biopsych.2012.06.029
更新日期：2013-01-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1986-03-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2013.03.027
更新日期：2013-10-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2005.11.017
更新日期：2006-08-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2005.04.016
更新日期：2005-09-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2014.08.017
更新日期：2015-11-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(02)01490-7
更新日期：2003-01-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0006-3223(96)00298-3
更新日期：1997-07-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.10.003
更新日期：2013-02-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(95)00063-1
更新日期：1995-12-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.10.028
更新日期：2005-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.biopsych.2016.04.003
更新日期：2016-11-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2005.09.012
更新日期：2005-11-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：2007-12-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1976-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0006-3223(92)90132-j
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：
更新日期：1976-08-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：1990-10-15 00:00:00
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pub_type： 杂志文章
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更新日期：2004-01-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(93)90023-7
更新日期：1993-06-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.01.001
更新日期：2009-08-15 00:00:00
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pub_type： 杂志文章
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更新日期：1988-11-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：2020-01-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(93)90077-q
更新日期：1993-08-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(85)90175-1
更新日期：1985-11-01 00:00:00
