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Association of the APOE epsilon 4 allele with clinical subtypes of late life depression.

Abstract：

:The APOE genotypes of 45 elderly inpatients with major depression were determined to investigate the relationship of this disorder to irreversible dementia in late life. We specifically tested the hypothesis that the frequency of the APOE epsilon 4 allele is elevated in depressed elders with cognitive impairment or psychotic features, subtypes that have been reported to be at increased risk of developing Alzheimer's disease (AD). The frequency of epsilon 4 allele was not elevated in the overall group of 45 inpatients and, contrary to our expectation, was not associated with cognitive impairment in this group. In contrast, the epsilon 4 allele frequency for the patients with psychotic features was nearly four times that for the patients without psychotic features and nearly double that of elderly controls. These data suggest that elderly depressed inpatients with cognitive impairment are at risk for developing AD by an epsilon 4-independent pathway, while those with psychotic features are at risk for developing AD by an epsilon 4-dependent pathway. These findings suggest that subtypes of idiopathic major depression in late life may serve as landmarks that distinguish separable pathogenetic pathways to AD.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Zubenko GS,Henderson R,Stiffler JS,Stabler S,Rosen J,Kaplan BB

doi

10.1016/s0006-3223(96)00046-7

subject

Has Abstract

pub_date

1996-11-15 00:00:00

pages

1008-16

issue

10

eissn

0006-3223

issn

1873-2402

pii

S0006322396000467

journal_volume

40

pub_type

杂志文章

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