Abstract：
:We have investigated the relationship between the concentration of homovanillic acid in human plasma (pHVA) and plasma anti-D1 and anti-D2 dopamine receptor activity in chronic schizophrenic patients whose neuroleptic dosage was changed. The change in pHVA level correlated with that in anti-D1, not anti-D2 activity, thus suggesting that the neuroleptic-induced changes in pHVA concentration may be associated with the blocking of D1- as well as D2- receptors. The change of scores on the Scale for the Assessment of Negative Symptoms did not significantly correlate with changes in anti-D1 or anti-D2 activity, but did so correlated with the change in pHVA level.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Suzuki E,Kanba S,Nibuya M,Koshikawa H,Nakaki T,Yagi Gdoi
10.1016/0006-3223(92)90229-ssubject
Has Abstractpub_date
1992-02-15 00:00:00pages
357-64issue
4eissn
0006-3223issn
1873-2402pii
0006-3223(92)90229-Sjournal_volume
31pub_type
临床试验,杂志文章,随机对照试验abstract：:The benzodiazepines are generally safe and effective drugs with usually only minor side effects, dose-related sedation being the most common. A range of paradoxical effects can occur of which release of aggressive and hostile feelings has excited most attention. These responses are idiosyncratic however, as most patie...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1981-12-01 00:00:00
abstract：BACKGROUND:Chronic stress is a major health concern, often leading to depression, anxiety, or when severe enough, posttraumatic stress disorder. While many studies demonstrate that the amygdala is hyperresponsive in patients with these disorders, the cellular neurophysiological effects of chronic stress on the systems ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.02.008
更新日期：2010-06-15 00:00:00
abstract：BACKGROUND:Evidence suggests that the noradrenergic and corticotrophin-releasing factor (CRF) systems play critical roles in relapse and stress-related behaviors. In particular, behavioral studies point to a serial signaling process initiated by β-adrenergic receptors that requires CRF receptor (CRFR)-dependent signali...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.12.030
更新日期：2011-06-01 00:00:00
abstract：:Neuroendocrine functions in depressed patients with major affective disorders were serially investigated by the Dexamethasone Suppression Test (DST), the thyrotropin-releasing hormone (TRH) stimulation test, and the plasma TRH-like immunoreactivity (TRH-LI) measurement. Prior to antidepressant therapy, the sensitivity...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(87)90184-3
更新日期：1987-05-01 00:00:00
abstract：BACKGROUND:The relationship between vitamin status and cognitive functioning has been addressed in several recent studies with inconclusive results. The purpose of this study was to examine separate and combined effects of serum vitamin B12 and folic acid on episodic memory functioning in very old age. METHODS:Four st...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(98)00234-0
更新日期：1999-06-01 00:00:00
abstract：BACKGROUND:Association analysis identified the homeobox transcription factor, ENGRAILED 2 (EN2), as a possible autism spectrum disorder (ASD) susceptibility gene (ASD [MIM 608636]; EN2 [MIM 131310]). The common alleles (underlined) of two intronic single nucleotide polymorphisms (SNPs), rs1861972 (A/G) and rs1861973 (C...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.05.027
更新日期：2009-11-15 00:00:00
abstract：BACKGROUND:Alpha synuclein has been found elevated in dopamine neurons of cocaine abusers and in rats whose alcohol preference is inbred. METHODS:The alpha synuclein mRNA expression level was measured by quantitative polymerase chain reaction in the blood of 75 male alcoholics and 69 nondrinking healthy control subjec...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.09.016
更新日期：2004-12-15 00:00:00
abstract：BACKGROUND:Several lines of evidence suggest the presence of abnormalities in the endocannabinoid (eCB) system in schizophrenia (SCZ). However, there are limited in vivo measures of the eCB system in SCZ. METHODS:Twenty five male SCZ subjects (SCZs) (18 antipsychotic treated and 7 antipsychotic free) were compared wit...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2015.08.021
更新日期：2016-06-15 00:00:00
abstract：:An early-onset, familial form of Alzheimer's disease (AD) has been reported to be linked to a locus on the long arm of chromosome 21 (21q21). Furthermore, duplications in the vicinity of this locus involving the beta-amyloid gene and the proto-oncogene ets-2 have been reported in association with AD. The structural ge...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(89)90236-9
更新日期：1989-03-15 00:00:00
abstract：:Tourette syndrome (TS) is thought to involve dopaminergic disturbances, but the nature of those disturbances remains controversial. Existing hypotheses suggest that TS involves 1) supersensitive dopamine receptors, 2) overactive dopamine transporters that cause low tonic but high phasic dopamine, 3) presynaptic dysfun...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2018.02.1172
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Recent studies have raised concerns about subtle long-lasting neurobiological changes that might be triggered by exposure to Cannabis derivatives, especially in a critical phase of brain maturation, such as puberty. The mesolimbic dopamine (DA) system, involved in the processing of drug-induced reward, is a ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.05.006
更新日期：2004-07-15 00:00:00
abstract：BACKGROUND:Few studies have sought to identify, in a regionally unbiased way, the precise cortical and subcortical regions that are affected by white matter abnormalities in attention-deficit/hyperactivity disorder (ADHD). This study aimed to derive a comprehensive, whole-brain characterization of connectomic disturban...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2013.12.013
更新日期：2014-10-15 00:00:00
abstract：BACKGROUND:The endocannabinoid anandamide may be involved in the regulation of emotional reactivity. In particular, it has been shown that pharmacological inhibition of the enzyme fatty acid amide hydrolase (FAAH), which catalyzes the intracellular hydrolysis of anandamide, elicits anxiolytic-like and antidepressant-li...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.12.001
更新日期：2007-11-15 00:00:00
abstract：BACKGROUND:A number of studies have provided evidence for genetic modulation of brain structure in unaffected family members (FM) of schizophrenia patients using conventional volumetric analysis. High-dimensional pattern classification methods have been reported to have the capacity to determine subtle and spatially co...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.03.015
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The 5HTTLPR genetic variant of the serotonin transporter (SERT), which consists of a long (SERT-l) and short (SERT-s) allele, has emerged as a major factor influencing emotional behavior and brain anatomy. The pulvinar nucleus of the thalamus projects to important limbic nuclei including the amygdala and cin...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.08.047
更新日期：2007-03-15 00:00:00
abstract：BACKGROUND:Recent reports suggest that gamma-glutamyl transferase (GGT) decreases with coffee intake. The aim of this study was to examine the joint influence of alcohol, tobacco, cotinine, coffee, and caffeine on biological markers of heavy drinking in an alcoholic population. METHODS:Subjects were 160 alcohol-depend...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(97)00438-1
更新日期：1998-10-01 00:00:00
abstract：:Posttraumatic stress disorder (PTSD) is a stress-related psychiatric disorder that is thought to emerge from complex interactions among traumatic events and multiple genetic factors. Epigenetic regulation lies at the heart of these interactions and mediates the lasting effects of the environment on gene regulation. An...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2015.04.003
更新日期：2015-09-01 00:00:00
abstract：:This study evaluated the effect of an acute reduction in catecholamine synthesis produced by alpha-methyl-para-tyrosine (AMPT), a tyrosine hydroxylase inhibitor, on cocaine-induced euphoria. In a blinded, placebo-controlled study, AMPT (1 g p.o. T.I.D.) was given to 10 non-treatment-seeking cocaine abusers prior to in...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0006-3223(96)00331-9
更新日期：1997-08-01 00:00:00
abstract：:Eighteen unmedicated patients suffering from major depressive disorder with melancholia (DSM-III) were examined for abnormalities in peripheral serotonin (5-HT) and related metabolites. Serotonin in platelet-free plasma and in platelets from melancholics was significantly reduced to 30% and 60% of their respective con...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(87)90100-4
更新日期：1987-12-01 00:00:00
abstract：:Ten pedigrees systematically ascertained in Germany were tested for linkage to chromosome 5q11-q13. In order to replicate the previous report by Sherrington et al (1988), families with a bipolar family member were omitted from the lod score calculations, all diagnoses were based upon Research Diagnostic Criteria, and ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(92)90008-n
更新日期：1992-01-01 00:00:00
abstract：:Previous studies have demonstrated blunted beta-adrenergic responsivity in leukocytes from depressed patients. We sought to determine if this blunted cyclic adenosine monophosphate (AMP) response is specific for beta-adrenergic receptors (homologous), or whether other adenylyl cyclase-coupled receptors are also involv...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/S0006-3223(97)00154-6
更新日期：1997-11-15 00:00:00
abstract：:The volume of the entorhinal region is significantly reduced in postmortem brains of schizophrenics compared with controls (p less than 0.017). In addition, a significant reduction of neurons (p less than 0.017), but no significant increase in absolute glial cell numbers, is found. These results are consistent with th...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(88)90162-x
更新日期：1988-09-01 00:00:00
abstract：:Urinary MHPG concentrations and platelet 3H-imipramine binding (Bmax, Kd) were measured in 20 psychiatric inpatients with diagnoses of major depressive disorder. Clinical assessments were performed using the Present State Examination (PSE) interview, and several dimensions of symptomatology were constructed on the bas...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(88)90003-0
更新日期：1988-03-15 00:00:00
abstract：:The authors examined thyrotropin-releasing hormone (TRH) stimulation testing in the neuroendocrine evaluation of DSM-III major depressive disorder in 26 consecutive medication-free, medically healthy patients meeting a primary DSM-III diagnosis of axis II personality disorder. Thyroid-stimulating hormone (TSH) respons...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(93)90077-q
更新日期：1993-08-15 00:00:00
abstract：BACKGROUND:Metyrapone blocks cortisol synthesis which results in removal of negative feedback, a stimulation of hypothalamic corticotropin releasing factor (CRF) and a reduction in delta sleep. We previously reported a diminished delta sleep and hypothalamic-pituitary-adrenal (HPA) response to metyrapone in men with po...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/j.biopsych.2006.08.018
更新日期：2007-04-15 00:00:00
abstract：BACKGROUND:The DBH gene regulates plasma dopamine beta-hydroxylase activity (pDbetaH). Two single nucleotide polymorphisms (SNPs), -1021C-->T (rs1611115; SNP1) and +1603C-->T (rs6271; SNP3), independently influence pDbetaH. Another SNP, commonly known as DBH Taq1A (rs2519152; SNP2) is associated with attention-deficit/...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.02.017
更新日期：2006-11-15 00:00:00
abstract：BACKGROUND:Since low serum iron has been reported in a variety of neuropsychiatric motor disorders, this study was conducted to examine serum iron in patients with a catatonic disorder. METHODS:Forty catatonic and 40 noncatatonic psychotic patients were studied in relation to serum iron levels. The association of seru...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(98)00137-1
更新日期：1999-03-15 00:00:00
abstract：BACKGROUND:Quantitative genetic analysis of basic mouse behaviors is a powerful tool to identify novel genetic phenotypes contributing to neurobehavioral disorders. Here, we analyzed genetic contributions to single-trial, long-term social and nonsocial recognition and subsequently studied the functional impact of an id...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2015.01.017
更新日期：2015-10-01 00:00:00
abstract：:Serum free thyroxine (FT4), total thyroxine (TT4), and Brief Psychiatric Rating Scale (BPRS) measurements were obtained following hospital admission and at 2-week intervals during hospitalization in 80 male psychiatric inpatients with a variety of major psychotic and affective disorders. A strong correlation between t...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(89)90148-0
更新日期：1989-01-01 00:00:00
abstract：:This paper reviews and correlates three separate recent findings that implicate the one-carbon cycle in neuropsychiatric disease: (i) the demonstration by kinetic studies that the Vmax of methionine adenosine transferase (MAT) is reduced in some schizophrenics and depressives and is increased in some manics, and that ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
