β-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism.


BACKGROUND:Evidence suggests that the noradrenergic and corticotrophin-releasing factor (CRF) systems play critical roles in relapse and stress-related behaviors. In particular, behavioral studies point to a serial signaling process initiated by β-adrenergic receptors that requires CRF receptor (CRFR)-dependent signaling in the bed nucleus of the stria terminalis (BNST) to produce stress-induced relapse to cocaine seeking. METHODS:We used whole cell patch clamp recordings from acutely prepared mouse brain slices to examine the actions of β-adrenergic receptors and CRFR1 on excitatory transmission in BNST. We examined the effects of agonists of these receptors in slices prepared from naive, sham, and cocaine-conditioned mice. RESULTS:β(1)-adrenergic receptor activation within the BNST produces an enhancement of excitatory synaptic transmission that requires CRFR1-dependent signaling. We show that chronic cocaine administration transiently disrupts β(1)-adrenergic- and CRFR1-dependent enhancement of glutamatergic transmission, that this disruption wanes with time, and that it can be reintroduced with a cocaine challenge. CONCLUSIONS:In total, these studies identify a circuit mechanism within the BNST that may play an important role in CRF- and norepinephrine-regulated behaviors.


Biol Psychiatry


Biological psychiatry


Nobis WP,Kash TL,Silberman Y,Winder DG




Has Abstract


2011-06-01 00:00:00














  • Cortical thinning in cingulate and occipital cortices in first episode schizophrenia.

    abstract:BACKGROUND:Postmortem studies examining discrete regions show reduced cortical thickness in schizophrenia. Computational image analysis methods allow spatially detailed cortical thickness measurements across the entire cortex in 3D, but have not addressed thickness changes in cingulate or other cortices bordering the m...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Narr KL,Toga AW,Szeszko P,Thompson PM,Woods RP,Robinson D,Sevy S,Wang Y,Schrock K,Bilder RM

    更新日期:2005-07-01 00:00:00

  • Adolescent fears as predictors of depression.

    abstract:BACKGROUND:Recent studies raise questions on the relationship between adolescent fears and risk for major depression. METHODS:An epidemiologic sample of 776 young people received psychiatric assessments in 1983, 1985-1986, and 1992. Prospective associations were examined between fears in adolescence and future episode...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Pine DS,Cohen P,Brook J

    更新日期:2001-11-01 00:00:00

  • Selected quantitative EEG (QEEG) and event-related potential (ERP) variables as discriminators for positive and negative schizophrenia.

    abstract::Heterogeneity is a major obstacle in the search for biological substrates in schizophrenia. The positive and negative distinction, even if too simplistic, may improve our understanding of underlying processes. Frontostriatal deficits have been related to negative symptoms, while dysfunction of the dominant temporal lo...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Gerez M,Tello A

    更新日期:1995-07-01 00:00:00

  • Neural responses to sad facial expressions in major depression following cognitive behavioral therapy.

    abstract:BACKGROUND:Affective facial processing is an important component of interpersonal relationships. The neural substrate has been examined following treatment with antidepressant medication but not with psychological therapies. The present study investigated the neural correlates of implicit processing of sad facial expre...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Fu CH,Williams SC,Cleare AJ,Scott J,Mitterschiffthaler MT,Walsh ND,Donaldson C,Suckling J,Andrew C,Steiner H,Murray RM

    更新日期:2008-09-15 00:00:00

  • Heart rate variability during sleep and the early development of posttraumatic stress disorder.

    abstract:BACKGROUND:Noradrenergic function has been linked to posttraumatic stress disorder (PTSD) and might have a role in mediating sleep disturbances of the disorder. Our objective was to relate a peripheral manifestation of noradrenergic function, sympathetic nervous system activity as indexed by heart rate variability duri...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Mellman TA,Knorr BR,Pigeon WR,Leiter JC,Akay M

    更新日期:2004-05-01 00:00:00

  • Heart period and variability findings in preschool children with posttraumatic stress symptoms.

    abstract:BACKGROUND:Traumatic experiences for young children might result in profound neurodevelopmental changes, compared with adults. Our aim was to examine autonomic control of heart rate in traumatized young children. METHODS:Sixty-two children who had suffered traumas and 62 nontraumatized control children, aged 20 months...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Scheeringa MS,Zeanah CH,Myers L,Putnam F

    更新日期:2004-04-01 00:00:00

  • Effects of metyrapone on hypothalamic-pituitary-adrenal axis and sleep in women with post-traumatic stress disorder.

    abstract:BACKGROUND:Metyrapone blocks cortisol synthesis which results in removal of negative feedback, a stimulation of hypothalamic corticotropin releasing factor (CRF) and a reduction in delta sleep. We previously reported a diminished delta sleep and hypothalamic-pituitary-adrenal (HPA) response to metyrapone in men with po...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Otte C,Lenoci M,Metzler T,Yehuda R,Marmar CR,Neylan TC

    更新日期:2007-04-15 00:00:00

  • Effects of ketamine on thought disorder, working memory, and semantic memory in healthy volunteers.

    abstract:BACKGROUND:The N-methyl-D-aspartate receptor antagonist, ketamine, produces a clinical syndrome of thought disorder, perceptual distortion, and cognitive impairment. METHODS:We have administered ketamine to healthy volunteers to characterize the formal thought disorder and specific memory dysfunction associated with k...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Adler CM,Goldberg TE,Malhotra AK,Pickar D,Breier A

    更新日期:1998-06-01 00:00:00

  • A review of GHRH stimulation test in psychiatry.

    abstract::We critically reviewed controlled investigations of the growth hormone releasing hormone (GHRH) stimulation test in depression, anorexia nervosa, bulimia, panic disorder, schizophrenia, and Alzheimer's disease. Comparisons of GH responsiveness between patients and controls within each diagnostic category were equivoca...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Skare SS,Dysken MW,Billington CJ

    更新日期:1994-08-15 00:00:00

  • Cerebral blood flow in schizophrenia: effects of memory processing on regional activation.

    abstract::Regional cerebral blood flow (rCBF) was measured with the 133Xenon clearance technique and a high resolution (254 detectors) scanner during the performance of a verbal and a facial memory task in 18 patients with schizophrenia and 18 sociodemographically matched controls. Patients and controls had comparable resting r...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Gur RE,Jaggi JL,Shtasel DL,Ragland JD,Gur RC

    更新日期:1994-01-01 00:00:00

  • Metabolism of an ingested serine load in psychotic and nonpsychotic subjects.

    abstract::Our previous studies have shown that in psychotics, the plasma serine level is abnormally high and that plasma serine hydroxymethyltransferase (which cleaves serine to glycine) activity is abnormally low as compared with that in nonpsychotic subjects. In this study, psychotic and nonpsychotic subjects ingested a large...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Wilcox J,Waziri R,Sherman A,Mott J

    更新日期:1985-01-01 00:00:00

  • Neurochemical alterations in asymptomatic abstinent cocaine users: a proton magnetic resonance spectroscopy study.

    abstract::Cocaine can cause a variety of neuropsychiatric and neurobehavioral complications; however, it is uncertain whether cocaine causes persistent cerebral structural and neurochemical abnormalities in asymptomatic users. We studied 52 African-American men (26 human immunodeficiency virus-negative asymptomatic heavy cocain...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Chang L,Mehringer CM,Ernst T,Melchor R,Myers H,Forney D,Satz P

    更新日期:1997-12-15 00:00:00

  • A family study of nailfold plexus visibility in psychotic disorders.

    abstract::It has been proposed that the nailfold subpapillary plexus visibility score (PVS) may be a marker of susceptibility to schizophrenia. To further investigate this hypothesis, we evaluated plexus visibility in a sample of 61 chronic schizophrenics, a large sample of first-episode psychotic patients and their first-degre...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Clementz BA,Iacono WG,Ficken J,Beiser M

    更新日期:1992-02-15 00:00:00

  • Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder.

    abstract:BACKGROUND:Volumetric imaging research has shown abnormal brain morphology in adults with posttraumatic stress disorder (PTSD) when compared with matched control subjects. In this article, we present brain imaging findings from a study of children with PTSD symptoms. METHODS:Twenty-four children between the ages of 7 ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Carrion VG,Weems CF,Eliez S,Patwardhan A,Brown W,Ray RD,Reiss AL

    更新日期:2001-12-15 00:00:00

  • Neuroendocrine effects of ovine corticotropin-releasing hormone in panic disorder patients.

    abstract::A number of neuroendocrine abnormalities have been reported in panic disorder patients: the most extensively studied being disturbances of hypothalamic-pituitary-adrenal function (Curtis et al. 1982; Leiberman et al. 1983; Uhde et al. 1988). The recent sequencing and synthesis of corticotropin-releasing hormone now al...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Rapaport MH,Risch SC,Golshan S,Gillin JC

    更新日期:1989-08-01 00:00:00

  • Mood and hormone responses to psychological challenge in adolescent males with conduct problems.

    abstract:BACKGROUND:Relations between stress hormones and antisocial behavior are understudied. METHODS:A subsample (n = 335) of at-risk males recruited in first grade for a longitudinal study were recruited at approximately 16 years of age for a laboratory study, including two psychological challenges: describing their worst ...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: McBurnett K,Raine A,Stouthamer-Loeber M,Loeber R,Kumar AM,Kumar M,Lahey BB

    更新日期:2005-05-15 00:00:00

  • Neural changes associated with treatment outcome in children with externalizing problems.

    abstract:BACKGROUND:The current study directly investigated whether changes in the neural correlates of self-regulation (SR) are associated with the effectiveness of treatment for the externalizing problems of children. METHODS:Seventy-one children 8-12 years of age with clinical levels of externalizing behavior and their fami...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Woltering S,Granic I,Lamm C,Lewis MD

    更新日期:2011-11-01 00:00:00

  • Automatic activation of the semantic network in schizophrenia: evidence from event-related brain potentials.

    abstract:BACKGROUND:Language disorder associated with schizophrenia might be due to disturbances in both automatic activation and mechanisms of controlled attention. The contribution of each process to semantic memory dysfunction has not been determined for schizophrenia, and the semantic priming paradigm is well-suited for add...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Condray R,Siegle GJ,Cohen JD,van Kammen DP,Steinhauer SR

    更新日期:2003-12-01 00:00:00

  • The Na,K-ATPase hypothesis for bipolar illness.

    abstract::A cellular model for bipolar illness is presented. It is propounded that alterations in the activity of the membrane sodium- and potassium-activated adenosine triphosphatase pump (Na,K-ATPase) may be responsible for alterations in neuronal excitability and activity. Specifically, a reduction in Na,K-ATPase activity ca...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: el-Mallakh RS,Wyatt RJ

    更新日期:1995-02-15 00:00:00

  • Depressive Rumination, the Default-Mode Network, and the Dark Matter of Clinical Neuroscience.

    abstract::The intuitive association between self-focused rumination in major depressive disorder (MDD) and the self-referential operations performed by the brain's default-mode network (DMN) has prompted interest in examining the role of the DMN in MDD. In this article, we present meta-analytic findings showing reliably increas...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Hamilton JP,Farmer M,Fogelman P,Gotlib IH

    更新日期:2015-08-15 00:00:00

  • Evidence for a susceptibility locus on chromosome 10p15 in early-onset obsessive-compulsive disorder.

    abstract:BACKGROUND:The goal of this study was to identify chromosomal regions likely to contain susceptibility loci for obsessive-compulsive disorder (OCD). METHODS:We conducted a genome-wide linkage scan, with average marker spacing less than 10 centimorgans (cM), in 121 subjects from 26 families ascertained through probands...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Hanna GL,Veenstra-Vanderweele J,Cox NJ,Van Etten M,Fischer DJ,Himle JA,Bivens NC,Wu X,Roe CA,Hennessy KA,Dickel DE,Leventhal BL,Cook EH Jr

    更新日期:2007-10-15 00:00:00

  • Long-term test-retest reliability of event-related potentials in normals and alcoholics.

    abstract::The long-term test-retest reliability of event-related potentials (ERP) measures was examined in a group of 44 controls and 71 chronic alcoholics, retested after an average of 14 months. Correlational analyses revealed moderately significant test-retest correlations for visual and auditory target N1, N2, and P3 amplit...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Sinha R,Bernardy N,Parsons OA

    更新日期:1992-12-01 00:00:00

  • CSF beta-endorphin-like immunoreactivity in delirium.

    abstract::Cerebrospinal fluid beta-endorphin-like immunoreactivity (CSF BLI) was determined for 69 patients who met DSM-III criteria for delirium and for 8 controls. The CSF BLI was significantly lower in the delirious patient group than in the controls (12.5 +/- 3.0 pg/ml versus 15.0 +/- 3.4 pg/ml, p less than 0.05). CSF BLI h...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Koponen H,Stenbäck U,Mattila E,Reinikainen K,Soininen H,Riekkinen PJ

    更新日期:1989-04-01 00:00:00

  • Serotonin uptake and efflux in blood platelets from untreated and neuroleptic-treated schizophrenics.

    abstract::Earlier studies on platelet serotonin uptake in schizophrenia have given equivocal results. In this study, platelet serotonin uptake in diluted plasma was assessed in 23 drug-free and 19 neuroleptic-treated schizophrenics, compared to 70 controls. The maximal uptake rate, Vmax, was slightly but significantly lower in ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Lingjaerde O

    更新日期:1983-12-01 00:00:00

  • Electroencephalographic activity and plasma ACTH during ethanol-induced euphoria.

    abstract::Covariance of brain electrical activity (EEG), plasma adrenocorticotrophic hormone (ACTH) and cortisol levels, and mood states were determined for healthy adult men during the first 2 hr after ingestion of ethanol or ethanol placebo under controlled double-blind conditions. Analysis of integrated plasma ACTH and corti...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Lukas SE,Mendelson JH

    更新日期:1988-01-15 00:00:00

  • Short-term effects of the calcium channel blocker nimodipine (Bay-e-9736) in the management of primary degenerative dementia.

    abstract::The etiology of Alzheimer's dementia (AD) is unknown, but several neurotransmitters, e.g., acetylcholine, have been implicated. Recently, the group of calcium channel antagonists have been reviewed for their potential neuropsychiatric applications. These agents are capable of enhancing cholinergic tone, neurofilament/...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Tollefson GD

    更新日期:1990-05-15 00:00:00

  • Seasonal rhythm of platelet 3H-imipramine binding in normal controls.

    abstract::The densities of platelet 3H-imipramine sites were determined by repetitive measures of 11 normal controls over the course of 1 year. A significant seasonal variation was found, with a circannual peak on February 17 and a nadir on August 18. The estimated amplitude of this rhythm was +/- 599.54 fmol/mg, which fluctuat...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: DeMet EM,Chicz-DeMet A,Fleischmann J

    更新日期:1989-09-01 00:00:00

  • A Common Polymorphism in a Williams Syndrome Gene Predicts Amygdala Reactivity and Extraversion in Healthy Adults.

    abstract:BACKGROUND:Williams syndrome (WS), a genetic disorder resulting from hemizygous microdeletion of chromosome 7q11.23, has emerged as a model for identifying the genetic architecture of socioemotional behavior. Common polymorphisms in GTF2I, which is found within the WS microdeletion, have been associated with reduced so...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Swartz JR,Waller R,Bogdan R,Knodt AR,Sabhlok A,Hyde LW,Hariri AR

    更新日期:2017-02-01 00:00:00

  • Enhancement of Psychosocial Treatment With D-Cycloserine: Models, Moderators, and Future Directions.

    abstract::Advances in the understanding of the neurobiology of fear extinction have resulted in the development of d-cycloserine (DCS), a partial glutamatergic N-methyl-D-aspartate agonist, as an augmentation strategy for exposure treatment. We review a decade of research that has focused on the efficacy of DCS for augmenting t...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Otto MW,Kredlow MA,Smits JAJ,Hofmann SG,Tolin DF,de Kleine RA,van Minnen A,Evins AE,Pollack MH

    更新日期:2016-08-15 00:00:00

  • The effects of stimulant medication on working memory functional connectivity in attention-deficit/hyperactivity disorder.

    abstract:BACKGROUND:Working memory impairments are commonly found in attention-deficit/hyperactivity disorder (ADHD) and often improve with psychostimulant treatment. Little is known about how these medications affect the function of frontoparietal brain regions engaged for working memory. This study used functional magnetic re...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,随机对照试验


    authors: Wong CG,Stevens MC

    更新日期:2012-03-01 00:00:00