β-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism.


BACKGROUND:Evidence suggests that the noradrenergic and corticotrophin-releasing factor (CRF) systems play critical roles in relapse and stress-related behaviors. In particular, behavioral studies point to a serial signaling process initiated by β-adrenergic receptors that requires CRF receptor (CRFR)-dependent signaling in the bed nucleus of the stria terminalis (BNST) to produce stress-induced relapse to cocaine seeking. METHODS:We used whole cell patch clamp recordings from acutely prepared mouse brain slices to examine the actions of β-adrenergic receptors and CRFR1 on excitatory transmission in BNST. We examined the effects of agonists of these receptors in slices prepared from naive, sham, and cocaine-conditioned mice. RESULTS:β(1)-adrenergic receptor activation within the BNST produces an enhancement of excitatory synaptic transmission that requires CRFR1-dependent signaling. We show that chronic cocaine administration transiently disrupts β(1)-adrenergic- and CRFR1-dependent enhancement of glutamatergic transmission, that this disruption wanes with time, and that it can be reintroduced with a cocaine challenge. CONCLUSIONS:In total, these studies identify a circuit mechanism within the BNST that may play an important role in CRF- and norepinephrine-regulated behaviors.


Biol Psychiatry


Biological psychiatry


Nobis WP,Kash TL,Silberman Y,Winder DG




Has Abstract


2011-06-01 00:00:00














  • Association of the APOE epsilon 4 allele with clinical subtypes of late life depression.

    abstract::The APOE genotypes of 45 elderly inpatients with major depression were determined to investigate the relationship of this disorder to irreversible dementia in late life. We specifically tested the hypothesis that the frequency of the APOE epsilon 4 allele is elevated in depressed elders with cognitive impairment or ps...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Zubenko GS,Henderson R,Stiffler JS,Stabler S,Rosen J,Kaplan BB

    更新日期:1996-11-15 00:00:00

  • Benzodiazepines as antidepressants: does GABA play a role in depression?

    abstract::Benzodiazepines, the most widely prescribed psychotropic drugs, are often used in patients with depressive disorders, either alone or in combination with standard antidepressants. This review evaluates the efficacy of benzodiazepines (alprazolam, diazepam, chlordiazepoxide) as established in acute-phase, randomized co...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,meta分析


    authors: Petty F,Trivedi MH,Fulton M,Rush AJ

    更新日期:1995-11-01 00:00:00

  • Impaired inter-hemispheric integration in bipolar disorder revealed with brain network analyses.

    abstract:BACKGROUND:This represents the first graph theory-based brain network analysis study in bipolar disorder, a chronic and disabling psychiatric disorder characterized by severe mood swings. Many imaging studies have investigated white matter in bipolar disorder, with results suggesting abnormal white matter structural in...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Leow A,Ajilore O,Zhan L,Arienzo D,GadElkarim J,Zhang A,Moody T,Van Horn J,Feusner J,Kumar A,Thompson P,Altshuler L

    更新日期:2013-01-15 00:00:00

  • Topiramate for the treatment of binge eating disorder associated with obesity: a placebo-controlled study.

    abstract:BACKGROUND:In a single-center, placebo-controlled study, topiramate reduced binge eating and weight in patients with binge eating disorder (BED) and obesity. The current investigation evaluated the safety and efficacy of topiramate in a multicenter, placebo-controlled trial. METHODS:Eligible patients between 18 and 65...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: McElroy SL,Hudson JI,Capece JA,Beyers K,Fisher AC,Rosenthal NR,Topiramate Binge Eating Disorder Research Group.

    更新日期:2007-05-01 00:00:00

  • Human Freud-2/CC2D1B: a novel repressor of postsynaptic serotonin-1A receptor expression.

    abstract:BACKGROUND:Altered expression of serotonin-1A (5-HT1A) receptors, both presynaptic in the raphe nuclei and post-synaptic in limbic and cortical target areas, has been implicated in mood disorders such as major depression and anxiety. Within the 5-HT1A receptor gene, a powerful dual repressor element (DRE) is regulated ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Hadjighassem MR,Austin MC,Szewczyk B,Daigle M,Stockmeier CA,Albert PR

    更新日期:2009-08-01 00:00:00

  • Significant reductions in synapsin but not synaptophysin specific activity in the brains of some schizophrenics.

    abstract::The levels of the synaptic vesicle-associated proteins, synapsin and synaptophysin, were examined in human postmortem hippocampus from the brains of schizophrenics and age-matched controls using a quantitative western blot analysis. The schizophrenic samples had significantly lower levels of synapsin I than controls. ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Browning MD,Dudek EM,Rapier JL,Leonard S,Freedman R

    更新日期:1993-10-15 00:00:00

  • The functional neuroanatomy of anxiety: a study of three disorders using positron emission tomography and symptom provocation.

    abstract::Previous neuroimaging research has contributed insights regarding the neural substrates of specific psychiatric disorders. The purpose of this study was to determine the shared mediating neuroanatomy of anxiety symptoms across three different anxiety disorders. Data were pooled from 23 right-handed adult outpatients m...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Rauch SL,Savage CR,Alpert NM,Fischman AJ,Jenike MA

    更新日期:1997-09-15 00:00:00

  • Maternal prenatal cortisol and infant cognitive development: moderation by infant-mother attachment.

    abstract:BACKGROUND:Experimental animal studies suggest that early glucocorticoid exposure may have lasting effects on the neurodevelopment of the offspring; animal studies also suggest that this effect may be eliminated by positive postnatal rearing. The relevance of these findings to humans is not known. METHODS:We prospecti...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Bergman K,Sarkar P,Glover V,O'Connor TG

    更新日期:2010-06-01 00:00:00

  • Plasma corticotropin-releasing factor in depressed patients before and after the dexamethasone suppression test.

    abstract:BACKGROUND:Plasma cortisol, beta-endorphin, corticotropin, corticotropin-releasing factor, and salivary cortisol concentrations, resting and after ingestion of 1 mg of dexamethasone, were investigated in depressed patients and controls. METHODS:Fourteen outpatients from the psychiatric department diagnosed with depres...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Galard R,Catalán R,Castellanos JM,Gallart JM

    更新日期:2002-03-15 00:00:00

  • Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4).

    abstract::Both genetic and environmental factors have been associated with an increased risk for schizophrenia. These factors are not mutually exclusive; a single gene can be a genetic factor (due to a mutation in the gene sequence) and a target of a physiological response to an environmental stimulus, both with the common endp...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Levitt P,Ebert P,Mirnics K,Nimgaonkar VL,Lewis DA

    更新日期:2006-09-15 00:00:00

  • Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor system.

    abstract:BACKGROUND:Animal studies demonstrate that stress and negative affect enhance the release of the neuropeptide substance P (SP), which binds to the neurokinin 1 (NK1) receptor. This positron emission tomography (PET) study evaluated how the activity in the SP-NK1 receptor system in the amygdala was affected by fear prov...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Michelgård A,Appel L,Pissiota A,Frans O,Långström B,Bergström M,Fredrikson M

    更新日期:2007-04-15 00:00:00

  • Neurochemical abnormalities in anorexia nervosa: similarities to affective disorders.

    abstract::Certain investigators have asserted that the illness of anorexia nervosa is a form of hypothalamic disturbance. The relationship between 24-hr urine 3-methoxy-4-hydroxyphenylglycol (MHPG) and dexamethasone suppression tests was examined in 13 female patients with AN diagnosed by RDC. Patients showed a consistent assoc...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Gwirtsman HE,Gerner RH

    更新日期:1981-10-01 00:00:00

  • Olfactory sensitivity in major depressive disorder and obsessive compulsive disorder.

    abstract::Olfactory sensitivity to two odorants, isoamyl acetate and androsterone, was assessed in 14 obsessive compulsive disorder (OCD) patients, nine major depressive disorder (MDD) patients, and 16 sex- and age-matched healthy controls. Tests were performed during a drug-free period, and 3 and 6 weeks after initiation of an...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Gross-Isseroff R,Luca-Haimovici K,Sasson Y,Kindler S,Kotler M,Zohar J

    更新日期:1994-05-15 00:00:00

  • Hypothalamic-pituitary-adrenal axis dysregulation in dysphoric children and adolescents: cortisol reactivity to psychosocial stress from preschool through middle adolescence.

    abstract:BACKGROUND:Most depressed adults exhibit dysregulation of the hypothalamic-pituitary-adrenal axis, including cortisol hyperreactivity to psychosocial challenge. In contrast, remarkably little is known about hypothalamic-pituitary-adrenal axis activity in response to psychosocial challenge among at-risk children and ado...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Hankin BL,Badanes LS,Abela JR,Watamura SE

    更新日期:2010-09-01 00:00:00

  • Magnesium measures across the menstrual cycle in premenstrual syndrome.

    abstract::The purpose of this study was to evaluate blood magnesium (Mg) measures across the menstrual cycle in women with premenstrual syndrome (PMS) and control women. Longitudinal determinations of plasma, red blood cell (RBC) and mononuclear blood cell (MBC) Mg were made in 26 women with prospectively confirmed PMS and in a...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Rosenstein DL,Elin RJ,Hosseini JM,Grover G,Rubinow DR

    更新日期:1994-04-15 00:00:00

  • Markers of Psychosis Risk in the General Population.

    abstract::The categorical approach to defining schizophrenia spectrum disorders requires meeting established criteria. To advance early identification and intervention in young people, the field has progressed to studying help-seeking individuals who are at clinical high risk based on subthreshold psychosis spectrum symptoms, a...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Taylor JH,Calkins ME,Gur RE

    更新日期:2020-08-15 00:00:00

  • Elevated expression of integrin alpha(IIb) beta(IIIa) in drug-naïve, first-episode schizophrenic patients.

    abstract:BACKGROUND:Patients with schizophrenia have an increased risk over the general public of developing cardiovascular illness. It is unknown if there are functional changes in platelet surface receptors in schizophrenia. We therefore analyzed the surface expression of glycoprotein (GP)Ib, the integrin receptor alpha(IIb)b...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Walsh MT,Ryan M,Hillmann A,Condren R,Kenny D,Dinan T,Thakore JH

    更新日期:2002-11-01 00:00:00

  • Stimulated gene expression profiles as a blood marker of major depressive disorder.

    abstract:BACKGROUND:Major depressive disorder (MDD) is a moderately heritable disorder with a high lifetime prevalence. At present, laboratory blood tests to support MDD diagnosis are not available. METHODS:We used a classifier approach on blood gene expression profiles of a unique set of unmedicated subjects (MDD patients and...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Spijker S,Van Zanten JS,De Jong S,Penninx BW,van Dyck R,Zitman FG,Smit JH,Ylstra B,Smit AB,Hoogendijk WJ

    更新日期:2010-07-15 00:00:00

  • Progressive brain volume loss in schizophrenia over the course of the illness: evidence of maturational abnormalities in early adulthood.

    abstract:BACKGROUND:Considering the magnitude of the reported changes in brain volume over time in first-episode patients it is unlikely that these changes are constant over the life-span of the schizophrenic illness. Thus, one would expect the progression in brain volume change in schizophrenia to follow a more complex traject...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: van Haren NE,Hulshoff Pol HE,Schnack HG,Cahn W,Brans R,Carati I,Rais M,Kahn RS

    更新日期:2008-01-01 00:00:00

  • Biochemical plasticity of synaptic transmission: a critical review of Dale's Principle.

    abstract::"Dale's Principle" states that each neuron releases one and only one synaptic transmitter. Mental disorders and behavioral drug effects are attributed to activation or blockade of one or more of these specific transmitters. A series of biochemical, electrophysiological, and behavioral studies suggests the alternative ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Sabelli HC,Mosnaim AD,Vazquez AJ,Giardina WJ,Borison RL,Pedemonte WA

    更新日期:1976-08-01 00:00:00

  • Regional prefrontal gray and white matter abnormalities in bipolar disorder.

    abstract:BACKGROUND:Previous magnetic resonance imaging (MRI) studies indicate that compared with healthy volunteers, patients with bipolar disorder have structural and functional abnormalities in the prefrontal cortex. The aim of this study was to investigate differences in prefrontal subregions between bipolar patients and he...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: López-Larson MP,DelBello MP,Zimmerman ME,Schwiers ML,Strakowski SM

    更新日期:2002-07-15 00:00:00

  • Individual differences in the response of dopamine receptor number to chronic haloperidol treatment.

    abstract::Previous studies of the haloperidol-induced increase in dopamine (DA) receptor number have not emphasized the existence of individual differences. The present study evaluated DA receptor number in individual rat and mouse caudates after haloperidol or drug-free feeding. After 3 months of haloperidol treatment of rats ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Bannet J,Belmaker RH,Ebstein RP

    更新日期:1981-11-01 00:00:00

  • Auditory sensory processing in autism: a magnetoencephalographic study.

    abstract:BACKGROUND:Patients with autism show clinical features suggestive of abnormal processing of auditory and other sensory information. We hypothesized that low-functioning autistic subjects present abnormalities in discriminating simple auditory stimuli at sensory system preconscious stages of cortical processing. METHOD...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Tecchio F,Benassi F,Zappasodi F,Gialloreti LE,Palermo M,Seri S,Rossini PM

    更新日期:2003-09-15 00:00:00

  • Prefrontal cortex function in nonpsychotic siblings of individuals with schizophrenia.

    abstract:BACKGROUND:Cognitive dysfunction is a hallmark feature of schizophrenia. In recent years, it has been proposed that impairments in attention, working memory and executive function may all reflect an underlying deficit in context processing. In individuals with schizophrenia, deficits in context processing have been ass...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Delawalla Z,Csernansky JG,Barch DM

    更新日期:2008-03-01 00:00:00

  • A comparison of symptom provocation procedures in psychiatry and other areas of medicine: implications for their ethical use in research.

    abstract:BACKGROUND:Symptom provocation is used to study a wide variety of medical disorders. In contrast to other areas of medicine, the application of these procedures to the study of mental disease has generated significant scientific, political, and public debate. Purported differences include an overabundance of these proc...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Avila MT,Conley RR,Carpenter WT

    更新日期:2001-10-01 00:00:00

  • A Pattern of Cognitive Deficits Stratified for Genetic and Environmental Risk Reliably Classifies Patients With Schizophrenia From Healthy Control Subjects.

    abstract:BACKGROUND:Schizophrenia risk is associated with both genetic and environmental risk factors. Furthermore, cognitive abnormalities are established core characteristics of schizophrenia. We aim to assess whether a classification approach encompassing risk factors, cognition, and their associations can discriminate patie...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Antonucci LA,Pergola G,Pigoni A,Dwyer D,Kambeitz-Ilankovic L,Penzel N,Romano R,Gelao B,Torretta S,Rampino A,Trojano M,Caforio G,Falkai P,Blasi G,Koutsouleris N,Bertolino A

    更新日期:2020-04-15 00:00:00

  • Neonatal lesions of the ventral hippocampal formation alter GABA-A receptor subunit mRNA expression in adult rat frontal pole.

    abstract:BACKGROUND:Gamma-aminobutyric acid (GABA)-ergic function is altered in schizophrenia. Of particular interest is the altered central nervous system expression of GABA-A receptor subunits, as changes in subunit expression account for recognized differences in mammalian brain function making them inviting targets for nove...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Mitchell CP,Grayson DR,Goldman MB

    更新日期:2005-01-01 00:00:00

  • Bilateral electrodermal asymmetry in euthymic patients with unipolar and bipolar affective disorders.

    abstract::Bilateral electrodermal activity (EDA) was examined in depressed patients in remission. In Study 1, 26 unipolar and 24 bipolar patients were compared to 46 psychiatrically healthy controls. Subjects were exposed to 17 86-dB pure tones while skin conductance was recorded from both hands. In Study 2, which was conducted...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Iacono WG,Tuason VB

    更新日期:1983-03-01 00:00:00

  • Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblings.

    abstract:BACKGROUND:Shared neuropathological characteristics of patients with schizophrenia and their siblings might represent intermediate phenotypes that could be used to investigate genetic susceptibility to the illness. We sought to discover previously unidentified gray matter volume differences in patients with schizophren...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Honea RA,Meyer-Lindenberg A,Hobbs KB,Pezawas L,Mattay VS,Egan MF,Verchinski B,Passingham RE,Weinberger DR,Callicott JH

    更新日期:2008-03-01 00:00:00

  • Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia.

    abstract:BACKGROUND:Growing evidence supports a pivotal role for the amygdala in the pathogenesis of bipolar disorder (BD) and schizophrenia (SZ). However, the occurrence of morphologic changes in the amygdala is currently controversial. METHODS:Total number and numeric density of neurons, neuronal somata size, and volume of t...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Berretta S,Pantazopoulos H,Lange N

    更新日期:2007-10-15 00:00:00