Abstract:
BACKGROUND:Recent research has demonstrated that clinical depression can emerge as early as the preschool period. Here, we examine brain function in children with a history of preschool-onset depression (PO-MDD) in comparison with healthy children. METHODS:Participants were medication naïve school-aged children (ages 7-11) with PO-MDD (n = 22) or no psychiatric history (n = 16) followed longitudinally as part of the Preschool Depression Study. We used functional magnetic resonance imaging measures of blood oxygen level-dependent signal to examine functional brain activity in response to emotionally valenced faces (sad, fearful, angry, happy, neutral) following a negative mood induction provided to all children. RESULTS:In categorical group comparisons, children with PO-MDD demonstrated increased activity in parietal cortex in response to sad faces but no differences in brain activity in a priori regions of interest (e.g., amygdala). However, in dimensional analyses, the severity of depression symptoms at the baseline preschool assessment predicted increased responses to sad faces in amygdala, hippocampal, parietal, and orbital frontal regions. CONCLUSIONS:School-aged children with a history of PO-MDD showed patterns of functional brain responses to emotionally evocative stimuli similar to patterns found in adults and adolescents with major depression. These patterns were most strongly related to the severity of depression during the preschool period, suggesting that the magnitude of early symptoms may be particularly important for understanding altered brain function. These findings suggest that an early episode of depression before age 6 may be associated with enduring brain change or may represent a biomarker that was present even before the preschool episode.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Barch DM,Gaffrey MS,Botteron KN,Belden AC,Luby JLdoi
10.1016/j.biopsych.2012.06.009subject
Has Abstractpub_date
2012-12-15 00:00:00pages
1035-42issue
12eissn
0006-3223issn
1873-2402pii
S0006-3223(12)00541-0journal_volume
72pub_type
杂志文章abstract::Buprenorphine is undergoing clinical trials for the treatment of opiate addiction. Although the abuse liability of sublingual buprenorphine is low, reports of intravenous abuse have appeared. This study describes the physiologic and subjective effects of intravenously administered buprenorphine and naloxone given alon...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
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更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:To study the influences of drug type and gender on the neuroendocrine response to neuroleptic treatment, we compared the endocrine actions of two neuroleptics with different receptor affinity profiles--a substituted benzamide, amisulpride, a selective D2-like dopamine antagonist; and a thioxanthene, flupenth...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0006-3223(98)00125-5
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pub_type: 杂志文章
doi:10.1016/s0006-3223(00)00915-x
更新日期:2000-09-15 00:00:00
abstract:BACKGROUND:Limited successes of gene finding for major depressive disorder (MDD) may be partly due to phenotypic heterogeneity. We tested whether the genetic load for MDD, bipolar disorder, and schizophrenia (SCZ) is increased in phenotypically more homogenous MDD patients identified by specific clinical characteristic...
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pub_type: 杂志文章
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更新日期:2017-02-15 00:00:00
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doi:10.1016/s0006-3223(01)01229-x
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pub_type: 杂志文章,随机对照试验
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更新日期:2005-12-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2015.11.009
更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
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更新日期:1998-10-01 00:00:00
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
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doi:10.1016/0006-3223(87)90152-1
更新日期:1987-03-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(92)90309-n
更新日期:1992-04-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1981-02-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1983-06-01 00:00:00
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更新日期:2009-06-15 00:00:00
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pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(99)00290-5
更新日期:2000-03-01 00:00:00
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pub_type: 评论,杂志文章,评审
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0006-3223(90)90039-5
更新日期:1990-05-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2020-04-15 00:00:00
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pub_type: 杂志文章
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更新日期:2003-05-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.biopsych.2019.09.029
更新日期:2020-06-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2010.05.030
更新日期:2010-11-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1992-05-15 00:00:00
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pub_type: 杂志文章
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更新日期:2005-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(01)01249-5
更新日期:2002-02-15 00:00:00
abstract::The present study was undertaken to investigate if acute anxiety can affect plasma concentrations of homovanillic acid (pHVA). Since elevated pHVA levels have been associated with severity of schizophrenic symptoms, the results of this study will help determine if the pHVA elevations are directly related to psychosis ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(95)00390-8
更新日期:1996-08-15 00:00:00