Abstract：
:The present study was undertaken to investigate if acute anxiety can affect plasma concentrations of homovanillic acid (pHVA). Since elevated pHVA levels have been associated with severity of schizophrenic symptoms, the results of this study will help determine if the pHVA elevations are directly related to psychosis or if anxiety is also a contributory factor. Anxiety was provoked in 10 young normal subjects by a combined paradigm of mental arithmetic task and threat of electrical shock. A significant increase in self-ratings of anxiety, blood pressure, and plasma levels of norepinephrine, 3-methoxy-4-hydroxyphenylethyleneglycol and growth hormone indicated that the paradigm used was effective in provoking anxiety; however, anxiety did not affect pHVA concentrations. The results may support the notion that increased pHVA levels in severely ill schizophrenic patients are related to the schizophrenic pathophysiology rather than to anxiety.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Zemishlany Z,Davidson Mdoi
10.1016/0006-3223(95)00390-8subject
Has Abstractpub_date
1996-08-15 00:00:00pages
247-52issue
4eissn
0006-3223issn
1873-2402pii
0006-3223(95)00390-8journal_volume
40pub_type
杂志文章abstract：BACKGROUND:Immune signaling pathways influence neurodevelopment and are hypothesized to contribute to the etiology of autism spectrum disorder (ASD). We aimed to assess risk of ASD in relation to levels of neonatal acute phase proteins (APPs), key components of innate immune function, measured in neonatal dried blood s...
journal_title：Biological psychiatry
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更新日期：2020-09-10 00:00:00
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2016-01-15 00:00:00
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journal_title：Biological psychiatry
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更新日期：1978-04-01 00:00:00
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更新日期：2012-04-15 00:00:00
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更新日期：2016-04-01 00:00:00
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journal_title：Biological psychiatry
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更新日期：2017-01-15 00:00:00
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更新日期：1989-02-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1978-12-01 00:00:00
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更新日期：2003-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1990-01-15 00:00:00
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pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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更新日期：1991-03-15 00:00:00
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doi：10.1016/j.biopsych.2016.03.2101
更新日期：2016-11-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2000-02-15 00:00:00
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doi：10.1016/j.biopsych.2019.06.006
更新日期：2020-01-15 00:00:00
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pub_type： 杂志文章
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更新日期：1992-10-15 00:00:00
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更新日期：2001-05-15 00:00:00
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pub_type： 杂志文章
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更新日期：2005-08-15 00:00:00
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更新日期：2018-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.12.012
更新日期：2013-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2000-08-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.06.002
更新日期：2008-02-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
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更新日期：1998-01-15 00:00:00
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journal_title：Biological psychiatry
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更新日期：2021-01-15 00:00:00
