Auditory event-related potentials and electrodermal activity in medicated and unmedicated schizophrenics.

Abstract:

:Event-related potentials (ERPs) and electrodermal activity were studied in 14 medicated schizophrenics, 17 unmedicated schizophrenics, and 23 age- and education-matched controls. Subjects were run in three auditory stimulus paradigms differing from the usual ERP paradigms in having interstimulus intervals greater than 12 sec to permit measurement of the longer latency skin conductance response (SCR). In every paradigm medicated but not unmedicated schizophrenics had smaller N120 amplitudes and fewer SCRs than controls. In addition, medicated schizophrenics showed reduced P200 amplitude and latency, longer P320 latency, and reduced skin conductance levels in certain paradigms. These effects cannot easily be attributed to different mental states of medicated and unmedicated patients, since their Brief Psychiatric Rating Scale scores were almost the same. It is more probable that antipsychotic and antiparkinsonian drugs reduced electrodermal activity through anticholinergic mechanisms and that the antipsychotic drugs attenuated N120 through other biological mechanisms.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Roth WT,Goodale J,Pfefferbaum A

doi

10.1016/0006-3223(91)90094-3

subject

Has Abstract

pub_date

1991-03-15 00:00:00

pages

585-99

issue

6

eissn

0006-3223

issn

1873-2402

pii

0006-3223(91)90094-3

journal_volume

29

pub_type

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