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Reduced startle reactivity and plasticity in transgenic mice overexpressing corticotropin-releasing hormone.

Abstract：

BACKGROUND:Corticotropin-releasing hormone (CRH) hyperactivity in transgenic mice overexpressing CRH in the brain (CRH-OE(2122)) appears to be associated with chronic stress-like alterations, including increased CRH content in the hypothalamus, changes in hypothalamus-pituitary-adrenal axis regulation, and increased heart rate and body temperature. In the present study, we investigated if sensory information processing of startling auditory stimuli was affected in CRH-OE(2122) mice. METHODS:CRH-OE(2122) mice (on C57BL/6J background) were subjected to a number of procedures probing sensory information processing mechanisms, including the acoustic startle response, habituation, and prepulse inhibition of startle. RESULTS:CRH-OE(2122) mice displayed reduced acoustic startle reactivity and increased motor activity during startle testing compared to wild-type mice. Furthermore, transgenic mice did not show habituation of the startle response after repeated exposure to the auditory stimulus, or habituation across procedures. CRH-OE(2122) mice exhibited robust impairments of prepulse inhibition in two different paradigms. CONCLUSIONS:The results in CRH-OE(2122) mice indicate that chronic CRH hyperactivity is associated with reductions in startle reactivity, habituation, and prepulse inhibition. The latter two abnormalities are also observed in schizophrenia patients. We conclude that chronic CRH excess may reduce behavioral reactivity to environmental stimuli and impair information processing mechanisms.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Dirks A,Groenink L,Schipholt MI,van der Gugten J,Hijzen TH,Geyer MA,Olivier B

doi

10.1016/s0006-3223(01)01323-3

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

583-90

issue

7

eissn

0006-3223

issn

1873-2402

pii

S0006322301013233

journal_volume

51

pub_type

杂志文章

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