Abstract:
:Because available evidence suggests that alterations in the serotonergic as well as dopaminergic tones underlie hallucinatory activity, we decided to investigate whether serotonin and dopamine pathways are modified in alcoholics with a history of hallucinosis. Brain serotonin has been shown to depend on the plasma ratio of its precursor tryptophan over other amino acids competing with it for brain entry. Similarly, brain dopamine depends on the plasma ratio of its precursors phenylalanine and dopamine over their competitors. Amino acid abnormalities are common in alcoholics. For this reason, we assessed whether alcoholics who had experienced hallucinations have alterations in amino acids believed to be associated with neurotransmitter modifications. Patients with a history of hallucinations were found to have a tryptophan ratio significantly lower than that of patients without such a history, and a tyrosine + phenylalanine ratio significantly higher. These data suggest that amino acid abnormalities believed to result in decreased brain serotonin and in increased brain dopamine render certain individuals more vulnerable to hallucinatory experiences.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Branchey L,Branchey M,Worner TM,Zucker D,Shaw S,Lieber CSdoi
10.1016/0006-3223(85)90175-1subject
Has Abstractpub_date
1985-11-01 00:00:00pages
1167-73issue
11eissn
0006-3223issn
1873-2402pii
0006-3223(85)90175-1journal_volume
20pub_type
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journal_title:Biological psychiatry
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更新日期:1982-03-01 00:00:00
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abstract::This article has been retracted, consistent with Elsevier Policy on Article Withdrawal. Please see . The Publisher apologises for any inconvenience this may cause. ...
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pub_type: 杂志文章
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更新日期:2006-02-14 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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doi:10.1016/j.biopsych.2007.05.027
更新日期:2008-03-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1016/j.biopsych.2007.03.015
更新日期:2008-01-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2005.04.041
更新日期:2005-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/j.biopsych.2004.11.023
更新日期:2005-02-15 00:00:00
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更新日期:2014-02-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2012.03.016
更新日期:2012-09-15 00:00:00
abstract::Although much is now known about the neural basis of fear acquisition, the mechanisms of fear inhibition or suppression remain largely obscure. Fear inhibition is studied in the laboratory through the use of an extinction procedure, in which an animal (typically a rat) is exposed to nonreinforced presentations of a co...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(02)01507-x
更新日期:2002-11-15 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(00)00969-0
更新日期:2000-09-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:1999-12-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.biopsych.2008.10.044
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更新日期:2018-05-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(01)01229-x
更新日期:2001-11-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(02)01668-2
更新日期:2003-05-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2007.11.009
更新日期:2008-04-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2011.03.022
更新日期:2011-06-15 00:00:00
abstract:BACKGROUND:In a single-center, placebo-controlled study, topiramate reduced binge eating and weight in patients with binge eating disorder (BED) and obesity. The current investigation evaluated the safety and efficacy of topiramate in a multicenter, placebo-controlled trial. METHODS:Eligible patients between 18 and 65...
journal_title:Biological psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.biopsych.2006.08.008
更新日期:2007-05-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2010.05.016
更新日期:2010-10-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2007.04.023
更新日期:2007-10-15 00:00:00
abstract::Federal regulations governing human subjects research call for additional protections for the "mentally disabled." However, there is currently no consensus definition of mental disability or guidelines for how these research subjects should be protected. This ambiguity complicates the work of institutional review boar...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(99)00168-7
更新日期:1999-10-15 00:00:00