RETRACTED: The Relationships Between White Matter Cerebral Metabolites and Clinical Manifestations in Geriatric Patients with Schizophrenia: A 4 Tesla Proton Magnetic Resonance Spectroscopy Study.

abstract：:There is recognition that the cognitive symptoms of schizophrenia have the most substantial impact on illness outcome. Domains of cognition reported to be significantly affected include serial learning, executive function, vigilance, and distractibility, to name a few. Dopamine activity at D1 receptors mediates many c...

journal_title：Biological psychiatry

authors： Friedman JI,Temporini H,Davis KL

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Anatomic magnetic resonance imaging (MRI) studies of attention-deficit/hyperactivity disorder (ADHD) have been limited by use of callosal rather than sulcal/gyral landmarks in defining cerebral lobes and functionally relevant sublobar regions (e.g., prefrontal cortex). We present an investigation of cerebral...

journal_title：Biological psychiatry

authors： Mostofsky SH,Cooper KL,Kates WR,Denckla MB,Kaufmann WE

更新日期：2002-10-15 00:00:00

abstract：BACKGROUND:Why do we jump the gun or speak out of turn? Waiting impulsivity has a preclinical basis as a predictor for the development of addiction. Here, we mapped the intrinsic neural correlates of waiting and dissociated it from stopping, both fundamental mechanisms of behavioral control. METHODS:We used a recently...

journal_title：Biological psychiatry

authors： Morris LS,Kundu P,Baek K,Irvine MA,Mechelmans DJ,Wood J,Harrison NA,Robbins TW,Bullmore ET,Voon V

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:Alcohol and tobacco dependence are highly comorbid disorders, with preclinical evidence suggesting a role for nicotinic acetylcholine receptors (nAChRs) in alcohol consumption. Varenicline, a partial nicotinic agonist with high affinity for the alpha4beta2 nAChR receptor, reduced ethanol intake in rodents. W...

journal_title：Biological psychiatry

authors： McKee SA,Harrison EL,O'Malley SS,Krishnan-Sarin S,Shi J,Tetrault JM,Picciotto MR,Petrakis IL,Estevez N,Balchunas E

更新日期：2009-07-15 00:00:00

abstract：BACKGROUND:We have previously shown that juvenile bipolar disorder (BPD) is a risk for substance use disorders (SUD). Here we examine the expression of both disorders in families of youth with BPD to evaluate the familial risk mechanism. METHODS:We studied 108 adolescent BPD probands with 187 parents (34 with SUD and ...

journal_title：Biological psychiatry

authors： Wilens TE,Biederman J,Adamson J,Monuteaux M,Henin A,Sgambati S,Santry A,Faraone SV

更新日期：2007-07-15 00:00:00

abstract：:Schizophrenia is a complex illness with multiple pathophysiologic factors that contribute to its psychopathology. One strategy to identify these factors is to observe them in isolation from each other, by characterizing their expression in the relatives of schizophrenic probands. By Mendel's second law, each genetic f...

journal_title：Biological psychiatry

authors： Waldo MC,Adler LE,Leonard S,Olincy A,Ross RG,Harris JG,Freedman R

更新日期：2000-02-01 00:00:00

abstract：:Absence of skin conductance response (SCR) and failure of its habituation are psychophysiological signs observed in most schizophrenics. In the present experiments, skin conductance activity was studied in rats before and after intraventricular administration of 6-hydroxydopa (6-OHdopa), a neurotoxin that selectively ...

journal_title：Biological psychiatry

authors： Yamamoto K,Hoshino T,Takahashi Y,Kaneko H,Ozawa N

更新日期：1991-02-15 00:00:00

abstract：:There has been an explosion of interest in the study of microorganisms inhabiting the gastrointestinal tract (gut microbiota) and their impact on host health and physiology. Accumulating data suggest that altered communication between gut microbiota and host systems could participate in disorders such as obesity, diab...

journal_title：Biological psychiatry

authors： Bruce-Keller AJ,Salbaum JM,Berthoud HR

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Monoamine oxidase (MAO) is a critical enzyme in deamination of biogenic amines and may be involved in the pathophysiology of major psychosis, including mood disorder and schizophrenia. Recently, evidence for genetic association between the MAO-A gene and bipolar mood disorder was obtained in Caucasians. MET...

journal_title：Biological psychiatry

authors： Sasaki T,Hattori M,Sakai T,Kato T,Kunugi H,Hirose T,Nanko S

更新日期：1998-11-01 00:00:00

abstract：:A group of 231 psychiatric patients were evaluated (with the Wechsler Adult Intelligence Scale and the Halstead-Reitan Neuropsychological Test Battery) before and after electroconvulsive therapy. Improvement during the course of therapy was shown in 96% of the measures and significant improvement (p less than 0.05) oc...

journal_title：Biological psychiatry

authors： Malloy FW,Small IF,Miller MJ,Milstein V,Stout JR

更新日期：1982-01-01 00:00:00

abstract：:Auditory evoked potentials were recorded using a paired click, conditioning-testing paradigm in 10 schizophrenics and in 10 normal subjects with no family history of psychotic disorder. The paradigm is used to demonstrate central nervous system gating of responsiveness to auditory stimuli by examining the extent to wh...

journal_title：Biological psychiatry

authors： Nagamoto HT,Adler LE,Waldo MC,Freedman R

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Several lines of evidence support the possibility that disturbances of dopamine (DA) function could contribute to alterations of weight, feeding, motor activity, and reward in anorexia nervosa (AN). METHODS:To assess possibly trait-related disturbances but avoid confounding effects of malnutrition, 10 women...

journal_title：Biological psychiatry

authors： Frank GK,Bailer UF,Henry SE,Drevets W,Meltzer CC,Price JC,Mathis CA,Wagner A,Hoge J,Ziolko S,Barbarich-Marsteller N,Weissfeld L,Kaye WH

更新日期：2005-12-01 00:00:00

abstract：:The ability of beta-adrenergic receptors to adapt to reductions in stimulation might be impaired in depressed or schizophrenic patients. To test this hypothesis 12 normal controls, 12 depressed patients resistant to tricyclic antidepressants, and 8 chronic schizophrenic patients were treated with propranolol 160 mg/da...

journal_title：Biological psychiatry

authors： Zohar J,Bannet J,Drummer D,Fisch R,Epstein RP,Belmaker RH

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:Suicide is a major risk for those with bipolar disorder, a risk amplified by comorbid substance abuse in some, but not all, previous studies. To further explore the relationships of substance abuse, suicide, and bipolarity as they present in clinical practice, we analyzed standardized clinical data from a la...

journal_title：Biological psychiatry

authors： Comtois KA,Russo JE,Roy-Byrne P,Ries RK

更新日期：2004-11-15 00:00:00

abstract：:Specific electroencephalogram (EEG) changes during clozapine therapy were prospectively studied in a cohort of 50 chronic state hospital patients with schizophrenia who were randomly assigned to one of three nonoverlapping clozapine serum level ranges (50-150 ng/mL, 200-300 ng/mL, and 350-450 ng/mL). EEGs were obtaine...

journal_title：Biological psychiatry

authors： Freudenreich O,Weiner RD,McEvoy JP

更新日期：1997-07-15 00:00:00

abstract：:Depressive episodes as reversible mental states are likely to be associated with equally reversible brain states. These can be examined with a variety of functional imaging methods using repeated measures designs. Studies using such an approach are reviewed. Changes in medial frontal, and in particular, cingulate cort...

journal_title：Biological psychiatry

authors： Ebert D,Ebmeier KP

更新日期：1996-06-15 00:00:00

abstract：BACKGROUND:Childhood-onset schizophrenia (COS), defined as onset of psychotic symptoms by age 12 years, is a rare and severe form of the disorder that seems to be clinically and neurobiologically continuous with the adult disorder. METHODS:We studied a rare cohort consisting of 98 probands; 71 of these probands receiv...

journal_title：Biological psychiatry

authors： Addington AM,Gornick M,Sporn AL,Gogtay N,Greenstein D,Lenane M,Gochman P,Baker N,Balkissoon R,Vakkalanka RK,Weinberger DR,Straub RE,Rapoport JL

更新日期：2004-05-15 00:00:00

abstract：:The pharmacokinetics of dexamethasone (DEX) were studied in 9 drug-free melancholically depressed patients and 10 healthy control subjects matched by sex and age. Each subject received 1 mg of DEX administered orally and by the (i.v.) route at 11:00 PM and serial blood samples were collected over the next 17 hours unt...

journal_title：Biological psychiatry

authors： O'Sullivan BT,Cutler DJ,Hunt GE,Walters C,Johnson GF,Caterson ID

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Reports relating phenylalanine kinetics and metabolism to psychiatric disorders led us to undertake the comprehensive screening of the phenylalanine hydroxylase (PAH) coding region and functional testing of discovered mutations in a sample of psychiatric patients and healthy control subjects. METHODS:Genomi...

journal_title：Biological psychiatry

authors： Richardson MA,Read LL,Clelland JD,Chao HM,Reilly MA,Romstad A,Suckow RF

更新日期：2003-03-15 00:00:00

abstract：BACKGROUND:Fragile X syndrome (FXS) is the most common known heritable cause of intellectual disability. Prior studies in FXS have observed a plateau in cognitive and adaptive behavioral development in early adolescence, suggesting that brain development in FXS may diverge from typical development during this period. ...

journal_title：Biological psychiatry

authors： Bray S,Hirt M,Jo B,Hall SS,Lightbody AA,Walter E,Chen K,Patnaik S,Reiss AL

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:A growing body of preclinical research suggests that brain glutamate systems may be involved in the pathophysiology of major depression and the mechanism of action of antidepressants. This is the first placebo-controlled, double-blinded trial to assess the treatment effects of a single dose of an N-methyl-D-...

journal_title：Biological psychiatry

authors： Berman RM,Cappiello A,Anand A,Oren DA,Heninger GR,Charney DS,Krystal JH

更新日期：2000-02-15 00:00:00

abstract：:Visibility of the nailfold vascular plexus has shown promise as a genetically transmitted marker for liability to schizophrenia. To assess whether this marker is specifically associated with negative or positive symptoms of schizophrenia, we reanalyzed patient data collected 20 years ago, well before interest in the n...

journal_title：Biological psychiatry

authors： Poole JH,Maricq HR,Alson E,Willerman L

更新日期：1991-04-15 00:00:00

abstract：BACKGROUND:Alpha synuclein has been found elevated in dopamine neurons of cocaine abusers and in rats whose alcohol preference is inbred. METHODS:The alpha synuclein mRNA expression level was measured by quantitative polymerase chain reaction in the blood of 75 male alcoholics and 69 nondrinking healthy control subjec...

journal_title：Biological psychiatry

authors： Bönsch D,Reulbach U,Bayerlein K,Hillemacher T,Kornhuber J,Bleich S

更新日期：2004-12-15 00:00:00

abstract：BACKGROUND:Recent findings suggest that both low and very high fasting blood glucose concentrations may be linked with depression, though whether type 2 diabetes is associated with depression may depend on awareness of the diagnosis. We explored the association between fasting glucose and type 2 diabetes (undiagnosed a...

journal_title：Biological psychiatry

authors： Gale CR,Kivimaki M,Lawlor DA,Carroll D,Phillips AC,Batty GD

更新日期：2010-01-15 00:00:00

abstract：BACKGROUND:A large number of studies suggest the presence of deficits in dorsolateral prefrontal cortex function during performance of working memory tasks in individuals with schizophrenia. However, working memory deficits may also present in other psychiatric disorders, such as major depression. It is not clear wheth...

journal_title：Biological psychiatry

authors： Barch DM,Sheline YI,Csernansky JG,Snyder AZ

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:The neurofibromatosis type 1 (Nf1) gene encodes a GTPase activating protein that negatively regulates small GTPases of the Ras family. METHODS:We assessed alcohol-related behaviors including alcohol sensitivity, dependent and nondependent drinking, and basal and alcohol-induced gamma-aminobutyric acid (GABA...

journal_title：Biological psychiatry

authors： Repunte-Canonigo V,Herman M,Kawamura T,Kranzler HR,Sherva R,Gelernter J,Farrer LA,Roberto M,Sanna PP

更新日期：2015-05-15 00:00:00

abstract：BACKGROUND:Considering the magnitude of the reported changes in brain volume over time in first-episode patients it is unlikely that these changes are constant over the life-span of the schizophrenic illness. Thus, one would expect the progression in brain volume change in schizophrenia to follow a more complex traject...

journal_title：Biological psychiatry

authors： van Haren NE,Hulshoff Pol HE,Schnack HG,Cahn W,Brans R,Carati I,Rais M,Kahn RS

更新日期：2008-01-01 00:00:00

abstract：:This report describes a series of experiments, all of which demonstrate a strong contribution of the behavioral pattern manifested at the time of initial amphetamine injection to the topography and development of the stereotypy that develops with chronic amphetamine intoxication. These initial behavioral patterns refl...

journal_title：Biological psychiatry

authors： Ellinwood EH Jr,kilbey MM

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has recently been demonstrated to have antidepressant effects. Some work suggests that rTMS over prefrontal cortex administered to healthy individuals produces acute elevations of mood and serum thyroid-stimulating hormone (TSH). We sought to determine whet...

journal_title：Biological psychiatry

authors： Szuba MP,O'Reardon JP,Rai AS,Snyder-Kastenberg J,Amsterdam JD,Gettes DR,Wassermann E,Evans DL

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Neuregulin-1 (Nrg1) is a pleiotropic signaling molecule that regulates neural development, and mutation of Nrg1 is a risk factor for schizophrenia. Cleavage of type I β1 Nrg1 isoform by Bace1 releases a secreted N-terminal fragment (Nrg1-ntfβ), which can bind to a cognate ErbB receptor to activate the specif...

journal_title：Biological psychiatry

authors： Luo X,He W,Hu X,Yan R

更新日期：2014-07-15 00:00:00