Abstract：
:Specific electroencephalogram (EEG) changes during clozapine therapy were prospectively studied in a cohort of 50 chronic state hospital patients with schizophrenia who were randomly assigned to one of three nonoverlapping clozapine serum level ranges (50-150 ng/mL, 200-300 ng/mL, and 350-450 ng/mL). EEGs were obtained before clozapine was instituted, and after 10 weeks of treatment. Fifty-three percent of patients showed EEG changes during the 10-week study period. We observed three seizures (6%), one in a patient on 900 mg (serum level 320 ng/mL) clozapine, and two in patients with lower clozapine serum levels (200-300 ng/mL) who had prior histories of seizures and inadequate valproate coverage. Thirteen percent of patients developed spikes with no relationship to dose or serum level of clozapine. Fifty-three percent of patients developed slowing on EEG. Compared to plasma levels below 300 ng/mL, a clozapine serum level between 350 and 450 ng/mL led to more frequent and more severe slowing. The EEG slowing correlated with observed sleepiness, although this factor was not sufficient to explain the severity of high-dose effects.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Freudenreich O,Weiner RD,McEvoy JPdoi
10.1016/S0006-3223(96)00298-3subject
Has Abstractpub_date
1997-07-15 00:00:00pages
132-7issue
2eissn
0006-3223issn
1873-2402pii
S0006-3223(96)00298-3journal_volume
42pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:Major depressive disorder is associated with disturbed circadian rhythms. To investigate the causal relationship between mood disorders and circadian clock disruption, previous studies in animal models have employed light/dark manipulations, global mutations of clock genes, or brain area lesions. However, li...
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更新日期：2007-02-15 00:00:00
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更新日期：1998-09-15 00:00:00
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doi：
更新日期：1977-06-01 00:00:00
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更新日期：2006-12-01 00:00:00
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