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The Na,K-ATPase hypothesis for bipolar illness.

Abstract：

:A cellular model for bipolar illness is presented. It is propounded that alterations in the activity of the membrane sodium- and potassium-activated adenosine triphosphatase pump (Na,K-ATPase) may be responsible for alterations in neuronal excitability and activity. Specifically, a reduction in Na,K-ATPase activity can lead to both mania and depression by increasing membrane excitability and decreasing neurotransmitter release, respectively. Supporting evidence is reviewed, and clinical and research implications are discussed.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

el-Mallakh RS,Wyatt RJ

doi

10.1016/0006-3223(94)00201-D

subject

Has Abstract

pub_date

1995-02-15 00:00:00

pages

235-44

issue

4

eissn

0006-3223

issn

1873-2402

pii

0006-3223(94)00201-D

journal_volume

37

pub_type

杂志文章,评审

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