Abstract:
BACKGROUND:Affective disorders are associated with prominent psychomotor abnormalities that may be related to changes in arousal or motivation due to altered catecholamine function. METHODS:We investigated relationships between performance on psychomotor tests of motor speed (reaction time and tapping speed) and visual tracking (trail making and dot placement) and catecholamine system function including cerebrospinal fluid (CSF) or urinary concentrations of catecholamines or their metabolites. Subjects were medicine-free inpatients with unipolar depression or with manic, depressive, or mixed episodes of bipolar disorder, and healthy controls matched by gender and stratified by age. RESULTS:Unipolar and bipolar depressed patients were impaired in motor speed, dexterity, and visual tracking, whereas manic and mixed patients did not differ from controls. Tapping speed correlated positively with CSF 3-methoxy-4-hydroxyphenylglycol in healthy controls and with CSF homovanillic acid in bipolar depressed subjects. Increased catecholamine function correlated with slowing in all other measures for patients with bipolar disorder. Relationships between catecholamines and psychomotor function were weaker in unipolar depressed subjects. Psychomotor function was related to severity of depression in bipolar, but not in unipolar, patients. CONCLUSIONS:These data suggest that catecholamine systems are associated with increased arousal and psychomotor impairment in patients with bipolar disorder. Similar behavioral changes have different neurotransmitter relationships in unipolar disorder.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Swann AC,Katz MM,Bowden CL,Berman NG,Stokes PEdoi
10.1016/s0006-3223(98)00172-3subject
Has Abstractpub_date
1999-04-15 00:00:00pages
979-88issue
8eissn
0006-3223issn
1873-2402pii
S0006-3223(98)00172-3journal_volume
45pub_type
杂志文章abstract::Disturbances in dopaminergic transmission have been implicated in the etiology of psychotic disorders. Interindividual differences in deoxyribonucleic acid (DNA) sequences coding for dopamine receptor proteins might contribute to the genetic background of these diseases. We have identified a variation in exon 1 of the...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(93)90236-7
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Previous studies indicate that adverse childhood events are associated with persistent changes in corticotropin-releasing factor neuronal systems. Our aim was to determine whether altered glucocorticoid feedback mediates the neuroendocrine sequelae of childhood trauma. METHODS:Standard and low-dose dexameth...
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(01)01286-0
更新日期:2001-12-01 00:00:00
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journal_title:Biological psychiatry
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doi:10.1016/0006-3223(94)00205-H
更新日期:1995-07-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(01)01074-5
更新日期:2001-10-15 00:00:00
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journal_title:Biological psychiatry
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更新日期:2020-06-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
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更新日期:1990-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
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更新日期:2003-08-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:1982-03-01 00:00:00
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journal_title:Biological psychiatry
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pub_type: 杂志文章,评审
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
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更新日期:2012-08-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2009-07-15 00:00:00
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journal_title:Biological psychiatry
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doi:10.1016/j.biopsych.2016.12.025
更新日期:2017-07-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/j.biopsych.2005.02.012
更新日期:2005-07-15 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1016/s0006-3223(96)00257-0
更新日期:1997-02-01 00:00:00
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journal_title:Biological psychiatry
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pub_type: 杂志文章
doi:
更新日期:1978-08-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2004.10.026
更新日期:2005-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.biopsych.2010.01.024
更新日期:2010-06-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.biopsych.2007.04.040
更新日期:2007-12-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0006-3223(96)00331-9
更新日期:1997-08-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(91)90091-y
更新日期:1991-03-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/0006-3223(95)00291-x
更新日期:1996-06-01 00:00:00
abstract::Thirty-nine patients with major depression were studied to determine the differential effects of desipramine (DMI) and fluoxetine (FLU) on thyroid hormones. Twenty-six percent showed some abnormality in baseline thyroid hormone levels. There were no demonstrable differences for any of the thyroid indices from baseline...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(93)90311-z
更新日期:1993-01-15 00:00:00
abstract:BACKGROUND:Previous reports of ventricular and hippocampal volumes in patients with bipolar disorder (BP) have been inconsistent in their findings. One possibility is that volumetric abnormalities are determined by disease subtype. Prior evidence suggests that psychotic (PBP) and nonpsychotic (NPBP) forms of BP are two...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2004.12.009
更新日期:2005-03-15 00:00:00