Pharmacological characterization of tardive akathisia.

abstract：BACKGROUND:Volumetric imaging research has shown abnormal brain morphology in adults with posttraumatic stress disorder (PTSD) when compared with matched control subjects. In this article, we present brain imaging findings from a study of children with PTSD symptoms. METHODS:Twenty-four children between the ages of 7 ...

journal_title：Biological psychiatry

authors： Carrion VG,Weems CF,Eliez S,Patwardhan A,Brown W,Ray RD,Reiss AL

更新日期：2001-12-15 00:00:00

abstract：:This paper is not a comprehensive review of the literature. Rather, it is a viewpoint based upon advances in other fields of medicine and genetics that may provide a model for guiding research in psychiatry. The paper discusses the major limitations of the medicines currently used to treat schizophrenia and bipolar il...

journal_title：Biological psychiatry

authors： Scolnick EM

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Identifying factors that modify responsiveness to pharmacotherapies for alcohol dependence is important for treatment planning. Cigarette smoking predicts more severe alcohol dependence and poorer treatment response in general. Nevertheless, there is limited research on cigarette smoking as a potential predi...

journal_title：Biological psychiatry

authors： Fucito LM,Park A,Gulliver SB,Mattson ME,Gueorguieva RV,O'Malley SS

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:The gene encoding the regulator of G-protein signaling 4 has recently been associated with susceptibility to schizophrenia. This finding is particularly interesting, because it was replicated within the same study and also because there are functional, positional, and expression data to support the regulator...

journal_title：Biological psychiatry

authors： Williams NM,Preece A,Spurlock G,Norton N,Williams HJ,McCreadie RG,Buckland P,Sharkey V,Chowdari KV,Zammit S,Nimgaonkar V,Kirov G,Owen MJ,O'Donovan MC

更新日期：2004-01-15 00:00:00

abstract：:The subjective sleep disturbance in posttraumatic stress disorder (PTSD), including the repetitive, stereotypical anxiety dream, suggests dysfunctional rapid eye movement (REM) sleep mechanisms. The polysomnograms of a group of physically healthy combat veterans with current PTSD were compared with those of an age-app...

journal_title：Biological psychiatry

authors： Ross RJ,Ball WA,Dinges DF,Kribbs NB,Morrison AR,Silver SM,Mulvaney FD

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Because researchers have reported that antidepressants increase the expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus, we investigated whether serum BDNF levels may be used as a putative biological marker for major depressive disorders (MDD). METHODS:We measured serum BDNF in the...

journal_title：Biological psychiatry

authors： Shimizu E,Hashimoto K,Okamura N,Koike K,Komatsu N,Kumakiri C,Nakazato M,Watanabe H,Shinoda N,Okada S,Iyo M

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to examine the functional neuroanatomy of episodic memory impairment in euthymic subjects with bipolar I disorder. There is evidence that individuals with bipolar disorder have cognitive impairments not only during mood episodes but also when they are euthymic. The most consi...

journal_title：Biological psychiatry

authors： Deckersbach T,Dougherty DD,Savage C,McMurrich S,Fischman AJ,Nierenberg A,Sachs G,Rauch SL

更新日期：2006-01-15 00:00:00

abstract：BACKGROUND:The transcription factor FoxO3a is highly expressed in brain, but little is known about the response of FoxO3a to behavioral stress and its impact in the associated behavioral changes. METHODS:We tested the response of brain FoxO3a in the learned helplessness (LH) paradigm and tested signaling pathways that...

journal_title：Biological psychiatry

authors： Zhou W,Chen L,Yang S,Li F,Li X

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The cognitive deficits of schizophrenia are largely resistant to current treatments and thus are a lifelong illness burden. The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) provides a reliable and valid assessment of cognition across ma...

journal_title：Biological psychiatry

authors： Sui J,Pearlson GD,Du Y,Yu Q,Jones TR,Chen J,Jiang T,Bustillo J,Calhoun VD

更新日期：2015-12-01 00:00:00

abstract：:Several clinical investigations have suggested that captopril, an angiotensin-converting enzyme inhibitor (ACEI), currently used as an antihypertensive agent, exhibited anti-depressant properties in humans. The present experiment was evaluated for potential antidepressive activity of captopril on the learned helplessn...

journal_title：Biological psychiatry

authors： Martin P,Massol J,Puech AJ

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Patients with autism show clinical features suggestive of abnormal processing of auditory and other sensory information. We hypothesized that low-functioning autistic subjects present abnormalities in discriminating simple auditory stimuli at sensory system preconscious stages of cortical processing. METHOD...

journal_title：Biological psychiatry

authors： Tecchio F,Benassi F,Zappasodi F,Gialloreti LE,Palermo M,Seri S,Rossini PM

更新日期：2003-09-15 00:00:00

abstract：:Twenty-eight residual schizophrenics hospitalized in a chronic institution with a 9 to 30 year history of disease, with predominantly negative symptoms were given carbamazepine. Carbamazepine was administered in a double-blind trial and therapeutic effects were measured by the Scale for the Assessment of Negative Symp...

journal_title：Biological psychiatry

authors： Nachshoni T,Levin Y,Levy A,Kritz A,Neumann M

更新日期：1994-01-01 00:00:00

abstract：:Prolactin (PRL) and cortisol responses to oral administration of d-1 fenfluramine hydrochloride (60 mg) and placebo were examined in patients with endogenous major depressive disorder on three separate occasions: prior to treatment with clomipramine (CMI), after 4 weeks of CMI administration (175-250) mg/day), and 3 w...

journal_title：Biological psychiatry

authors： Shapira B,Yagmur MJ,Gropp C,Newman M,Lerer B

更新日期：1992-05-15 00:00:00

abstract：BACKGROUND:The current study directly investigated whether changes in the neural correlates of self-regulation (SR) are associated with the effectiveness of treatment for the externalizing problems of children. METHODS:Seventy-one children 8-12 years of age with clinical levels of externalizing behavior and their fami...

journal_title：Biological psychiatry

authors： Woltering S,Granic I,Lamm C,Lewis MD

更新日期：2011-11-01 00:00:00

abstract：:Auditory evoked potentials were recorded using a paired click, conditioning-testing paradigm in 10 schizophrenics and in 10 normal subjects with no family history of psychotic disorder. The paradigm is used to demonstrate central nervous system gating of responsiveness to auditory stimuli by examining the extent to wh...

journal_title：Biological psychiatry

authors： Nagamoto HT,Adler LE,Waldo MC,Freedman R

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Currently, no pharmacological treatments for bipolar depression exist that exert rapid (within hours) antidepressant or antisuicidal effects. We previously reported that intravenous administration of the N-methyl-D-aspartate antagonist ketamine produced rapid antidepressant effects in patients with treatment...

journal_title：Biological psychiatry

authors： Zarate CA Jr,Brutsche NE,Ibrahim L,Franco-Chaves J,Diazgranados N,Cravchik A,Selter J,Marquardt CA,Liberty V,Luckenbaugh DA

更新日期：2012-06-01 00:00:00

abstract：:Magnetic resonance spectroscopy allows investigation of in vivo neurochemical pathology of schizophrenia. "First generation" studies, focusing on phosphorus and proton magnetic resonance spectroscopy, have suggested alterations in membrane phospholipid metabolism and reductions in N-acetyl aspartate in the frontal and...

journal_title：Biological psychiatry

authors： Keshavan MS,Stanley JA,Pettegrew JW

更新日期：2000-09-01 00:00:00

abstract：:Animal models of mental illness provide a foundation for evaluating hypotheses for the mechanistic causes of mental illness. Neurophysiological investigations of neural network activity in rodent models of mental dysfunction are reviewed from the conceptual framework of the discoordination hypothesis, which asserts th...

journal_title：Biological psychiatry

authors： Fenton AA

更新日期：2015-06-15 00:00:00

abstract：BACKGROUND:Neurotrophins mediate diverse biological responses, including maintenance and growth of neurons and synaptic plasticity in adult brain. This study examined whether suicide brain is associated with changes in the expression of neurotrophins. METHODS:Messenger ribonucleic acid (mRNA) levels of nerve growth fa...

journal_title：Biological psychiatry

authors： Dwivedi Y,Mondal AC,Rizavi HS,Conley RR

更新日期：2005-08-15 00:00:00

abstract：BACKGROUND:Depression is a complex neuropsychiatric syndrome that is often very severe and life threatening. In spite of the remarkable progress in understanding the neural biology, the etiopathophysiology of depression is still elusive. In this study, we have investigated molecular mechanisms in the prefrontal cortex ...

journal_title：Biological psychiatry

authors： Veeraiah P,Noronha JM,Maitra S,Bagga P,Khandelwal N,Chakravarty S,Kumar A,Patel AB

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Recent findings indicate that inhibitors of fatty acid amide hydrolase (FAAH) counteract the rewarding effects of nicotine in rats. Inhibition of FAAH increases levels of several endogenous substances in the brain, including the endocannabinoid anandamide and the noncannabinoid fatty acid ethanolamides oleoy...

journal_title：Biological psychiatry

authors： Mascia P,Pistis M,Justinova Z,Panlilio LV,Luchicchi A,Lecca S,Scherma M,Fratta W,Fadda P,Barnes C,Redhi GH,Yasar S,Le Foll B,Tanda G,Piomelli D,Goldberg SR

更新日期：2011-04-01 00:00:00

abstract：:We investigated the computerized electroencephalography (cEEG) in a group of 85 normal adolescents. The spatial frequency of the cEEG was analyzed using various multivariate statistical techniques. The factor analyses revealed three factors that accounted for most of the variability in the data and that could be inter...

journal_title：Biological psychiatry

authors： Volkow ND,Gomez-Mont F,Inamdar S,Lamella M,Prichep L,John R

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:Vagus nerve stimulation (VNS) has shown promising antidepressant effects in treatment-resistant depression, but the mechanisms of action are not known. Cerebrospinal fluid (CSF) studies in epilepsy patients show that VNS alters concentrations of monamines and gamma-aminobutyric acid (GABA), neurotransmitter ...

journal_title：Biological psychiatry

authors： Carpenter LL,Moreno FA,Kling MA,Anderson GM,Regenold WT,Labiner DM,Price LH

更新日期：2004-09-15 00:00:00

abstract：BACKGROUND:Insomnia symptoms are associated with vulnerability to age-related morbidity and mortality. Cross-sectional data suggest that accelerated biological aging may be a mechanism through which sleep influences risk. A novel method for determining age acceleration using epigenetic methylation to DNA has demonstrat...

journal_title：Biological psychiatry

authors： Carroll JE,Irwin MR,Levine M,Seeman TE,Absher D,Assimes T,Horvath S

更新日期：2017-01-15 00:00:00

abstract：BACKGROUND:Epidemiologic studies have identified psychological risk factors for specific physical diseases, but the biological mechanisms mediating these relationships remain poorly defined. METHODS:Social inhibition and autonomic nervous system (ANS) activity were assessed on multiple occasions in 54 gay men with asy...

journal_title：Biological psychiatry

authors： Cole SW,Kemeny ME,Fahey JL,Zack JA,Naliboff BD

更新日期：2003-12-15 00:00:00

abstract：BACKGROUND:Marijuana use by teenagers often predates the use of harder drugs, but the neurobiological underpinnings of such vulnerability are unknown. Animal studies suggest enhanced heroin self-administration (SA) and dysregulation of the endogenous opioid system in the nucleus accumbens shell (NAcsh) of adults follow...

journal_title：Biological psychiatry

authors： Tomasiewicz HC,Jacobs MM,Wilkinson MB,Wilson SP,Nestler EJ,Hurd YL

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:Cortical glutamate levels are elevated in bipolar disorder, but the interpretation of this increase is unclear because glutamate has metabolic as well as neurotransmitter roles. We investigated this by measuring vesicular glutamate transporter 1 (VGluT1) expression, which reflects activity at glutamate synap...

journal_title：Biological psychiatry

authors： Eastwood SL,Harrison PJ

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Two broad treatment options exist for switching antidepressants for depressed patients who fail to respond to a selective serotonin reuptake inhibitor (SSRI): either a second course of SSRI therapy or a different class of antidepressants. The goal of the present work was to conduct a meta-analysis of studies...

journal_title：Biological psychiatry

authors： Papakostas GI,Fava M,Thase ME

更新日期：2008-04-01 00:00:00

abstract：:To date, there has been little investigation of the neurobiological basis of emotion processing abnormalities in psychiatric populations. We have previously discussed two neural systems: 1) a ventral system, including the amygdala, insula, ventral striatum, ventral anterior cingulate gyrus, and prefrontal cortex, for ...

journal_title：Biological psychiatry

authors： Phillips ML,Drevets WC,Rauch SL,Lane R

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Evidence suggests that the noradrenergic and corticotrophin-releasing factor (CRF) systems play critical roles in relapse and stress-related behaviors. In particular, behavioral studies point to a serial signaling process initiated by β-adrenergic receptors that requires CRF receptor (CRFR)-dependent signali...

journal_title：Biological psychiatry

authors： Nobis WP,Kash TL,Silberman Y,Winder DG

更新日期：2011-06-01 00:00:00