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Neurobiology of emotion perception II: Implications for major psychiatric disorders.

Abstract：

:To date, there has been little investigation of the neurobiological basis of emotion processing abnormalities in psychiatric populations. We have previously discussed two neural systems: 1) a ventral system, including the amygdala, insula, ventral striatum, ventral anterior cingulate gyrus, and prefrontal cortex, for identification of the emotional significance of a stimulus, production of affective states, and automatic regulation of emotional responses; and 2) a dorsal system, including the hippocampus, dorsal anterior cingulate gyrus, and prefrontal cortex, for the effortful regulation of affective states and subsequent behavior. In this critical review, we have examined evidence from studies employing a variety of techniques for distinct patterns of structural and functional abnormalities in these neural systems in schizophrenia, bipolar disorder, and major depressive disorder. In each psychiatric disorder, the pattern of abnormalities may be associated with specific symptoms, including emotional flattening, anhedonia, and persecutory delusions in schizophrenia, prominent mood swings, emotional lability, and distractibility in bipolar disorder during depression and mania, and with depressed mood and anhedonia in major depressive disorder. We suggest that distinct patterns of structural and functional abnormalities in neural systems important for emotion processing are associated with specific symptoms of schizophrenia and bipolar and major depressive disorder.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Phillips ML,Drevets WC,Rauch SL,Lane R

doi

10.1016/s0006-3223(03)00171-9

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

515-28

issue

5

eissn

0006-3223

issn

1873-2402

pii

S0006322303001719

journal_volume

54

pub_type

杂志文章,评审

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