Abstract:
BACKGROUND:Brain imaging and behavioral studies suggest an inverse relationship between dopamine (DA) D2/D3 receptors and vulnerability to cocaine abuse, although most research has used males. For example, male monkeys that become dominant in a social group have significant elevations in D2/D3 receptor availability and are less vulnerable to cocaine reinforcement. METHODS:DA D2/D3 receptor availability was assessed in female cynomolgus monkeys (n = 16) with positron emission tomography (PET) while they were individually housed, 3 months after stable social hierarchies had formed, and again when individually housed. In addition, PET was used to examine changes in dopamine transporter (DAT) availability after social hierarchy formation. After imaging studies were complete, monkeys received implantation with indwelling intravenous catheters and self-administered cocaine (.001-.1 mg/kg/injection) under a fixed-ratio 30 schedule of reinforcement. Acquisition of cocaine reinforcement occurred when response rates were significantly higher than when saline was self-administered. RESULTS:Neither DAT nor D2/D3 receptor availability in the caudate nucleus and putamen was predictive of social rank, but both significantly changed after formation of social hierarchies. DA D2/D3 receptor availability significantly increased in females that became dominant, whereas DAT availability decreased in subordinate females. Dominant female monkeys acquired cocaine reinforcement at significantly lower doses than subordinate monkeys. CONCLUSIONS:The relationship between D2/D3 receptor availability and vulnerability to cocaine reinforcement seems, on the basis of these findings, opposite in females and males. These data indicate that the social environment profoundly affects the DA system but does so in ways that have different functional consequences for females than for males.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Nader MA,Nader SH,Czoty PW,Riddick NV,Gage HD,Gould RW,Blaylock BL,Kaplan JR,Garg PK,Davies HM,Morton D,Garg S,Reboussin BAdoi
10.1016/j.biopsych.2012.03.002subject
Has Abstractpub_date
2012-09-01 00:00:00pages
414-21issue
5eissn
0006-3223issn
1873-2402pii
S0006-3223(12)00215-6journal_volume
72pub_type
杂志文章abstract:BACKGROUND:Cognitive dysfunction in schizophrenia may be related to morphologic abnormalities of pyramidal neurons in the dorsal prefrontal cortex (dPFC) and the largest pyramidal neurons in deep layer 3 may be most affected. Immunoreactivity (IR) for the nonphosphorylated epitopes of neurofilament protein (NNFP) ident...
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Biological psychiatry
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doi:
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-03-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(94)00238-X
更新日期:1995-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-04-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2007-05-15 00:00:00
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pub_type: 杂志文章
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更新日期:2006-07-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2011-11-15 00:00:00
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pub_type: 杂志文章
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更新日期:1985-08-01 00:00:00
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更新日期:2017-07-15 00:00:00
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pub_type: 杂志文章
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更新日期:2014-03-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1983-02-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00